Novel metastasis models of human cancer in NOG mice.

abstract：:Enzootic nasal adenocarcinoma is a contagious tumour of the mucosal nasal glands affecting young adult sheep or goats. The disease occurs naturally in all continents except Australia and New Zealand. Clinical signs include continuous nasal discharge, respiratory distress, exophthalmos and skull deformations. The tumou...

journal_title：Current topics in microbiology and immunology

authors： De las Heras M,Ortín A,Cousens C,Minguijón E,Sharp JM

更新日期：2003-01-01 00:00:00

abstract：:Our knowledge of the organization and regulation of the murine hematopoietic stem cell hierarchy has, in large measure, been the result of the development of in vivo reconstitution assays for cells of various levels of differentiation. For example, many basic stem cell concepts were established using CFU-S as a paradi...

journal_title：Current topics in microbiology and immunology

authors： Dick JE

更新日期：1989-01-01 00:00:00

abstract：:It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes ...

journal_title：Current topics in microbiology and immunology

authors： Johannesson M,Hultqvist M,Holmdahl R

更新日期：2006-01-01 00:00:00

abstract：:Interleukin (IL)-22 is a member of the IL-10 family of cytokines, which, besides IL-10, contains seven additional cytokines. Although the founding member IL-10 is an important immunoregulatory cytokine that represses both innate and adaptive immunity, the other family members preferentially target epithelial cells and...

journal_title：Current topics in microbiology and immunology

authors： Eidenschenk C,Rutz S,Liesenfeld O,Ouyang W

更新日期：2014-01-01 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen, responsible for infections in the community and the healthcare setting. Although much of the attention is focused on the methicillin-resistant "variant" MRSA, the methicillin-susceptible counterpart (MSSA) remains a prime species in infections. The epidemiology of ...

journal_title：Current topics in microbiology and immunology

authors： Monaco M,Pimentel de Araujo F,Cruciani M,Coccia EM,Pantosti A

更新日期：2017-01-01 00:00:00

abstract：:In conventionally reared mice germinal centers (GCs) are chronically induced in Peyer's patches (PP), mesenteric lymph node (MLN), and isolated lymphoid follicles (ILF) of gut-associated lymphoid tissues (GALT), as a result of continuous B cell stimulation by commensal bacteria. It is generally thought that BCR-mediat...

journal_title：Current topics in microbiology and immunology

authors： Casola S,Rajewsky K

更新日期：2006-01-01 00:00:00

abstract：:Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that mol...

journal_title：Current topics in microbiology and immunology

authors： Frolov I,Frolova EI

更新日期：2019-01-01 00:00:00

abstract：:Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...

journal_title：Current topics in microbiology and immunology

authors： Baldwin MR,Barbieri JT

更新日期：2005-01-01 00:00:00

abstract：:The accumulation of protein aggregates has a fundamental role in the patophysiology of distinct neurodegenerative diseases. This phenomenon may have a common origin, where disruption of intracellular mechanisms related to protein homeostasis (here termed proteostasis) control during aging may result in abnormal protei...

journal_title：Current topics in microbiology and immunology

authors： Cabral-Miranda F,Hetz C

更新日期：2018-01-01 00:00:00

abstract：:Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompany...

journal_title：Current topics in microbiology and immunology

authors： Owens T

更新日期：2009-01-01 00:00:00

abstract：:Naturally arising CD25+CD4+ regulatory T cells, which express the transcription factor Foxp3, play key roles in the maintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological immune responses. The majority of them are produced by the normal thymus as a functionally ma...

journal_title：Current topics in microbiology and immunology

authors： Sakaguchi S,Setoguchi R,Yagi H,Nomura T

更新日期：2006-01-01 00:00:00

abstract：:The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. The Lyme disease spirochete has evolved mechanisms to sense its location in the infectious cycle, and use that information t...

journal_title：Current topics in microbiology and immunology

authors： Stevenson B,Seshu J

更新日期：2018-01-01 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00

abstract：:Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine available. The development of safe GAS vaccines is challenging, researchers are confronted with obstacles such as the occurrence of many unique serotypes (there are greater than 150 M types), antigenic variation within the same serotype,...

journal_title：Current topics in microbiology and immunology

authors： Henningham A,Gillen CM,Walker MJ

更新日期：2013-01-01 00:00:00

abstract：:The human stomach is a harsh and fluctuating environment for bacteria with hazards such as gastric acid and flow through of gastric contents into the intestine. H. pylori gains admission to a stable niche with nutrient access from exudates when attached to the epithelial cells under the mucus layer, whereof adherence ...

journal_title：Current topics in microbiology and immunology

authors： Padra M,Benktander J,Robinson K,Lindén SK

更新日期：2019-01-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell,...

journal_title：Current topics in microbiology and immunology

authors： Skoberne M,Beignon AS,Larsson M,Bhardwaj N

更新日期：2005-01-01 00:00:00

abstract：:This review will focus on the principal clinical and pathophysiological features of the anaemia of falciparum malaria, including the problems of treating malarial anaemia, and also will suggest how recent advances in genomics may help our understanding of cellular and molecular mechanisms underlying this syndrome. ...

journal_title：Current topics in microbiology and immunology

authors： Roberts DJ,Casals-Pascual C,Weatherall DJ

更新日期：2005-01-01 00:00:00

abstract：:Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization. Several key fact...

journal_title：Current topics in microbiology and immunology

authors： Beloin C,Roux A,Ghigo JM

更新日期：2008-01-01 00:00:00

abstract：:Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also ...

journal_title：Current topics in microbiology and immunology

authors： Kline JN

更新日期：2000-01-01 00:00:00

abstract：:Torque teno (TT) viruses have been more frequently reported in malignant biopsies when compared to normal control tissue. The possible contribution of TT virus infection to human carcinogenesis or the potential oncolytic functions of these virus infections are being discussed based on available experimental evidence. ...

journal_title：Current topics in microbiology and immunology

authors： zur Hausen H,de Villiers EM

更新日期：2009-01-01 00:00:00

abstract：:Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusivelywith the un...

journal_title：Current topics in microbiology and immunology

authors： Jones PL,Shi YB

更新日期：2003-01-01 00:00:00

abstract：:The possibility that a new form of human prion disease, variant Creutzfeldt-Jakob disease (vCJD) had occurred in the UK was first raised by the identification of a small number of cases with unusual clinical characteristics. Atypical features included a young age at death, a predominantly psychiatric presentation, a r...

journal_title：Current topics in microbiology and immunology

authors： Will RG,Ward HJ

更新日期：2004-01-01 00:00:00

abstract：:The prototypes of the human MYC and RAF gene families are orthologs of animal proto-oncogenes that were originally identified as transduced alleles in the genomes of highly oncogenic retroviruses. MYC and RAF genes are now established as key regulatory elements in normal cellular physiology, but also as major cancer d...

journal_title：Current topics in microbiology and immunology

authors： Stefan E,Bister K

更新日期：2017-01-01 00:00:00

abstract：:Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specif...

journal_title：Current topics in microbiology and immunology

authors： Kumar R,Amado RG

更新日期：2012-01-01 00:00:00

abstract：:The increased risk for severe dengue disease during secondary dengue virus (DENV) infections, along with the clinical and pathological evidence pointing to cytokines as the proximal mediators of disease, has interested cellular immunologists in exploring the role of DENV-specific T lymphocytes in the pathogenesis of d...

journal_title：Current topics in microbiology and immunology

authors： Rothman AL

更新日期：2010-01-01 00:00:00

abstract：:Adenoviruses contain genes that have evolved to control the host immune and inflammatory responses; however, it is not clear whether these genes function primarily to facilitate survival of the virus during acute infection or during its persistent phase. These issues have assumed greater importance as the use of adeno...

journal_title：Current topics in microbiology and immunology

authors： Fessler SP,Delgado-Lopez F,Horwitz MS

更新日期：2004-01-01 00:00:00

abstract：:The low-resource environment deprives healthcare providers caring for patients with Ebola virus disease (EVD) of many of the means employed for the critically ill that are available in better resourced settings, such as advanced therapeutic interventions and abundant staff. In addition to these limitations may be adde...

journal_title：Current topics in microbiology and immunology

authors： Sprecher A,Van Herp M,Rollin PE

更新日期：2017-01-01 00:00:00

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:Axonal transport ensures long-range delivery of essential components and signals between proximal and distal areas of the neuron, and it is crucial for neuronal homeostasis and survival. Several pathogens and virulence factors use this route to gain access to the central nervous system, exploiting the complex and stil...

journal_title：Current topics in microbiology and immunology

authors： Bercsenyi K,Giribaldi F,Schiavo G

更新日期：2013-01-01 00:00:00