Abstract:
:A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation are currently unknown. To investigate this, we implanted a flexible, 7 × 12 electrode array into the suprachoroidal space of normally-sighted, anesthetized cats. Multi-unit activity in the primary visual cortex was recorded in response to electrical stimulation using various return configurations: monopolar vitreous (MPV), common ground (CG), hexagonal (HX), monopolar remote (MPR) and bipolar (BP_N). MPV stimulation was found to be the most charge efficient and was most likely to induce cortical activity within safe charge limits. HX and CG stimulation were found to exhibit greater retinal selectivity compared to the MPV return at the expense of lower cortical yield and higher P50 charge levels, while cortical selectivity was unaffected by choice of return. Responses using MPR and widely spaced BP_N configurations were similar to those using the MPV return. These results suggest that choice of return configuration for a retinal prosthesis will be balanced between resolution and stimulation within safe charge limits.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Cicione R,Shivdasani MN,Fallon JB,Luu CD,Allen PJ,Rathbone GD,Shepherd RK,Williams CEdoi
10.1088/1741-2560/9/3/036009subject
Has Abstractpub_date
2012-06-01 00:00:00pages
036009issue
3eissn
1741-2560issn
1741-2552journal_volume
9pub_type
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更新日期:2009-10-01 00:00:00
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