当前位置： SCI文献检索 > Journal of Neural Engineering期刊下所有文献 > An analysis of glutamate spillover on the N-methyl-D-aspartate receptors at the cerebellar glomerulus.

An analysis of glutamate spillover on the N-methyl-D-aspartate receptors at the cerebellar glomerulus.

Abstract：

:Glutamate spillover is thought to play a significant role in increasing neural transmission at the mossy fiber/granule cell cerebellar glomerulus. Glutamate spillover has been shown to activate AMPA receptors at the glomerulus, and here we complete the characterization of spillover at the glomerulus by investigating the role of glutamate spillover in N-methyl-D-aspartate receptor (NMDA-R) activation. We present a quantitative model of glutamate spillover combining recent models of glutamate diffusion and NMDA-R binding to determine the open probabilities of NMDA-Rs over time at a neighbor synapse. Simulation results from a baseline set of physiologically realistic parameters show that glutamate spillover onto a single neighbor synapse, created by glutamate that diffuses from a point source into a restricted fractional 2D-3D space and the glutamate concentration created by neighboring glutamate release sites, is sufficient to elicit an NMDA-R peak open probability of 0.23, approximately 79% of that obtained by a direct release (peak open probability of 0.29). Thus, it would appear that glutamate spillover at the glomerulus at NMDA receptors is even more substantial than that seen at AMPA receptors.

journal_name

J Neural Eng

journal_title

Journal of neural engineering

authors

Mitchell CS,Feng SS,Lee RH

doi

10.1088/1741-2560/4/3/013

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

276-82

issue

3

eissn

1741-2560

issn

1741-2552

pii

S1741-2560(07)47026-4

journal_volume

4

pub_type

杂志文章

相关文献

Journal of Neural Engineering文献大全
  • Assessment of brain-machine interfaces from the perspective of people with paralysis.

    abstract：OBJECTIVE:One of the main goals of brain-machine interface (BMI) research is to restore function to people with paralysis. Currently, multiple BMI design features are being investigated, based on various input modalities (externally applied and surgically implantable sensors) and output modalities (e.g. control of comp...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/12/4/043002

    authors： Blabe CH,Gilja V,Chestek CA,Shenoy KV,Anderson KD,Henderson JM

    更新日期：2015-08-01 00:00:00

  • Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord.

    abstract：OBJECTIVE:We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/aaa87a

    authors： Capogrosso M,Gandar J,Greiner N,Moraud EM,Wenger N,Shkorbatova P,Musienko P,Minev I,Lacour S,Courtine G

    更新日期：2018-04-01 00:00:00

  • Effects of stimulation frequency and stimulation waveform on steady-state visual evoked potentials using a computer monitor.

    abstract：OBJECTIVE:A visual stimulator plays a vital part in brain-computer interfaces (BCIs) based on steady-state visual evoked potential (SSVEP). The properties of visual stimulation, such as frequency, color, and waveform, will influence SSVEP-based BCI performance to some extent. Recently, the computer monitor serves as a ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/ab2b7d

    authors： Chen X,Wang Y,Zhang S,Xu S,Gao X

    更新日期：2019-10-10 00:00:00

  • A novel training-free recognition method for SSVEP-based BCIs using dynamic window strategy.

    abstract：OBJECTIVE:Filter bank canonical correlation analysis (FBCCA) is a widely-used classification approach implemented in steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs). However, conventional detection algorithms for SSVEP recognition problems, including the FBCCA, were usually based on ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/ab914e

    authors： Chen Y,Yang C,Chen X,Wang Y,Gao X

    更新日期：2020-05-07 00:00:00

  • Optimal stimulus scheduling for active estimation of evoked brain networks.

    abstract：OBJECTIVE:We consider the problem of optimal probing to learn connections in an evoked dynamic network. Such a network, in which each edge measures an input-output relationship between sites in sensor/actuator-space, is relevant to emerging applications in neural mapping and neural connectivity estimation. APPROACH:We...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/12/6/066011

    authors： Kafashan M,Ching S

    更新日期：2015-12-01 00:00:00

  • Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate.

    abstract：OBJECTIVE:Analysis of intra- and perioperatively recorded cortical and basal ganglia local field potentials in human movement disorders has provided great insight into the pathophysiology of diseases such as Parkinson's, dystonia, and essential tremor. However, in order to better understand the network abnormalities an...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/11/1/016009

    authors： Ryapolova-Webb E,Afshar P,Stanslaski S,Denison T,de Hemptinne C,Bankiewicz K,Starr PA

    更新日期：2014-02-01 00:00:00

  • Long-term recording reliability of liquid crystal polymer µECoG arrays.

    abstract：OBJECTIVE:The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces. APPROACH:We evaluated the chronic reliability of novel 61-channel micro-electrocorticographic (µECoG) arrays in rats chronically implanted for over one year and usi...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/aae39d

    authors： Woods V,Trumpis M,Bent B,Palopoli-Trojani K,Chiang CH,Wang C,Yu C,Insanally MN,Froemke RC,Viventi J

    更新日期：2018-12-01 00:00:00

  • Intraneural sensory feedback restores grip force control and motor coordination while using a prosthetic hand.

    abstract：OBJECTIVE:Tactile afferents in the human hand provide fundamental information about hand-environment interactions, which is used by the brain to adapt the motor output to the physical properties of the object being manipulated. A hand amputation disrupts both afferent and efferent pathways from/to the hand, completely ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章,随机对照试验

    doi：10.1088/1741-2552/ab059b

    authors： Clemente F,Valle G,Controzzi M,Strauss I,Iberite F,Stieglitz T,Granata G,Rossini PM,Petrini F,Micera S,Cipriani C

    更新日期：2019-04-01 00:00:00

  • Nerve lesioning with direct current.

    abstract：:Spastic hypertonus (muscle over-activity due to exaggerated stretch reflexes) often develops in people with stroke, cerebral palsy, multiple sclerosis and spinal cord injury. Lesioning of nerves, e.g. with phenol or botulinum toxin is widely performed to reduce spastic hypertonus. We have explored the use of direct el...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/8/1/016005

    authors： Ravid EN,Gan LS,Todd K,Prochazka A

    更新日期：2011-02-01 00:00:00

  • A non-parametric method for automatic neural spike clustering based on the non-uniform distribution of the data.

    abstract：:In this paper, we propose a simple and straightforward algorithm for neural spike sorting. The algorithm is based on the observation that the distribution of a neural signal largely deviates from the uniform distribution and is rather unimodal. The detected spikes to be sorted are first processed with some feature ext...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/8/6/066014

    authors： Tiganj Z,Mboup M

    更新日期：2011-12-01 00:00:00

  • A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.

    abstract：OBJECTIVE:Neural reflexes regulate immune responses and homeostasis. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus n...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/aa7a42

    authors： Caravaca AS,Tsaava T,Goldman L,Silverman H,Riggott G,Chavan SS,Bouton C,Tracey KJ,Desimone R,Boyden ES,Sohal HS,Olofsson PS

    更新日期：2017-12-01 00:00:00

  • Hyperparameter-tuned prediction of somatic symptom disorder using functional near-infrared spectroscopy-based dynamic functional connectivity.

    abstract：OBJECTIVE:Somatic symptom disorder (SSD) is a reflection of medically unexplained physical symptoms that lead to distress and impairment in social and occupational functioning. SSD is phenomenologically diagnosed and its neurobiology remains unsolved. APPROACH:In this study, we performed hyper-parameter optimized clas...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/ab50b2

    authors： Eken A,Çolak B,Bal NB,Kuşman A,Kızılpınar SÇ,Akaslan DS,Baskak B

    更新日期：2019-12-16 00:00:00

  • Dynamics and coupling of fractional-order models of the motor cortex and central pattern generators.

    abstract：OBJECTIVE:Fractional calculus plays a key role in the analysis of neural dynamics. In particular, fractional calculus has been recently exploited for analyzing complex biological systems and capturing intrinsic phenomena. Also, artificial neural networks have been shown to have complex neuronal dynamics and characteris...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/ab8dd6

    authors： Lu Q

    更新日期：2020-06-12 00:00:00

  • EEG classification of imagined syllable rhythm using Hilbert spectrum methods.

    abstract：:We conducted an experiment to determine whether the rhythm with which imagined syllables are produced may be decoded from EEG recordings. High density EEG data were recorded for seven subjects while they produced in imagination one of two syllables in one of three different rhythms. We used a modified second-order bli...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/7/4/046006

    authors： Deng S,Srinivasan R,Lappas T,D'Zmura M

    更新日期：2010-08-01 00:00:00

  • Corrosion of silicon integrated circuits and lifetime predictions in implantable electronic devices.

    abstract：:Corrosion is a prime concern for active implantable devices. In this paper we review the principles underlying the concepts of hermetic packages and encapsulation, used to protect implanted electronics, some of which remain widely overlooked. We discuss how technological advances have created a need to update the way ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章,评审

    doi：10.1088/1741-2560/10/3/031002

    authors： Vanhoestenberghe A,Donaldson N

    更新日期：2013-06-01 00:00:00

  • On robust parameter estimation in brain-computer interfacing.

    abstract：OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/aa8232

    authors： Samek W,Nakajima S,Kawanabe M,Müller KR

    更新日期：2017-12-01 00:00:00

  • Facilitating stochastic resonance as a pre-emphasis method for neural spike detection.

    abstract：OBJECTIVE:We aim to increase the number of neural spikes that can be detected in a single channel extracellular neural recording. APPROACH:We propose a pre-emphasis method facilitating stochastic resonance (SR), where we introduce the band-pass-filtered noisy extracellular recording to an overdamped Brownian particle ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/abae8a

    authors： Güngör CB,Töreyin H

    更新日期：2020-09-18 00:00:00

  • Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.

    abstract：OBJECTIVE:This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. AP...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/abb63a

    authors： Barragan A,Preston C,Alvarez A,Bera T,Qin Y,Weinand M,Kasoff W,Witte RS

    更新日期：2020-10-30 00:00:00

  • Neural engineering: the process, applications, and its role in the future of medicine.

    abstract：OBJECTIVE:Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits. APPROACH:This progress was enabled by the team-based, inte...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章,评审

    doi：10.1088/1741-2552/ab4869

    authors： Ereifej ES,Shell CE,Schofield JS,Charkhkar H,Cuberovic I,Dorval AD,Graczyk EL,Kozai TDY,Otto KJ,Tyler DJ,Welle CG,Widge AS,Zariffa J,Moritz CT,Bourbeau DJ,Marasco PD

    更新日期：2019-11-12 00:00:00

  • A gait stability investigation into FES-assisted paraplegic walking based on the walker tipping index.

    abstract：:The gait outcome measures used in clinical trials of paraplegic locomotor training determine the effectiveness of improved walking function assisted by the functional electrical stimulation (FES) system. Focused on kinematic, kinetic or physiological changes of paraplegic patients, traditional methods cannot quantify ...

    journal_title：Journal of neural engineering

    pub_type： 临床试验,杂志文章

    doi：10.1088/1741-2560/6/6/066007

    authors： Ming D,Bai Y,Liu X,Qi H,Cheng L,Wan B,Hu Y,Wong Y,Luk KD,Leong JC

    更新日期：2009-12-01 00:00:00

  • Extracellular voltage thresholds for maximizing information extraction in primate auditory cortex: implications for a brain computer interface.

    abstract：OBJECTIVE:Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods. The optimal threshold for extracting information from auditory cortex has yet to be ide...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/ab7c19

    authors： Bigelow J,Malone B

    更新日期：2020-03-03 00:00:00

  • Different classification techniques considering brain computer interface applications.

    abstract：:In this work the application of different machine learning techniques for classification of mental tasks from electroencephalograph (EEG) signals is investigated. The main application for this research is the improvement of brain computer interface (BCI) systems. For this purpose, Bayesian graphical network, neural ne...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/3/2/008

    authors： Rezaei S,Tavakolian K,Nasrabadi AM,Setarehdan SK

    更新日期：2006-06-01 00:00:00

  • Biophysically realistic neuron models for simulation of cortical stimulation.

    abstract：OBJECTIVE:We implemented computational models of human and rat cortical neurons for simulating the neural response to cortical stimulation with electromagnetic fields. APPROACH:We adapted model neurons from the library of Blue Brain models to reflect biophysical and geometric properties of both adult rat and human cor...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/aadbb1

    authors： Aberra AS,Peterchev AV,Grill WM

    更新日期：2018-12-01 00:00:00

  • Suppression of scarring in peripheral nerve implants by drug elution.

    abstract：OBJECTIVE:Medical implants made of non-biological materials provoke a chronic inflammatory response, resulting in the deposition of a collagenous scar tissue (ST) layer on their surface, that gradually thickens over time. This is a critical problem for neural interfaces. Scar build-up on electrodes results in a progres...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/13/2/026006

    authors： FitzGerald JJ

    更新日期：2016-04-01 00:00:00

  • The use of tungsten as a chronically implanted material.

    abstract：:This review paper shows that tungsten should not generally be used as a chronically implanted material. The metal has a long implant history, from neuroscience, vascular medicine, radiography, orthopaedics, prosthodontics, and various other fields, primarily as a result of its high density, radiopacity, tensile streng...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章,评审

    doi：10.1088/1741-2552/aaa502

    authors： Shah Idil A,Donaldson N

    更新日期：2018-04-01 00:00:00

  • Carbon nanotube composite coating of neural microelectrodes preferentially improves the multiunit signal-to-noise ratio.

    abstract：:Extracellular metal microelectrodes are widely used to record single neuron activity in vivo. However, their signal-to-noise ratio (SNR) is often far from optimal due to their high impedance value. It has been recently reported that carbon nanotube (CNT) coatings may decrease microelectrode impedance, thus improving t...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/8/6/066013

    authors： Baranauskas G,Maggiolini E,Castagnola E,Ansaldo A,Mazzoni A,Angotzi GN,Vato A,Ricci D,Panzeri S,Fadiga L

    更新日期：2011-12-01 00:00:00

  • Stem cells from human exfoliated deciduous teeth differentiate toward neural cells in a medium dynamically cultured with Schwann cells in a series of polydimethylsiloxanes scaffolds.

    abstract：OBJECTIVE:Schwann cells (SCs) are primary structural and functional cells in the peripheral nervous system. These cells play a crucial role in peripheral nerve regeneration by releasing neurotrophic factors. This study evaluated the neural differentiation potential effects of stem cells from human exfoliated deciduous ...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/13/4/046005

    authors： Su WT,Pan YJ

    更新日期：2016-08-01 00:00:00

  • Safety and effectiveness considerations for clinical studies of visual prosthetic devices.

    abstract：:With the advent of new designs of visual prostheses for the blind, FDA is faced with developing guidance for evaluating their engineering, safety and patient performance. Visual prostheses are considered significant risk medical devices, and their use in human clinical trials must be approved by FDA under an investiga...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章,评审

    doi：10.1088/1741-2560/4/1/S14

    authors： Cohen ED

    更新日期：2007-03-01 00:00:00

  • Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.

    abstract：OBJECTIVE:Current mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale domains have a role in seizure generation that may be clinically signifi...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2560/13/2/026015

    authors： Vanleer AC,Blanco JA,Wagenaar JB,Viventi J,Contreras D,Litt B

    更新日期：2016-04-01 00:00:00

  • An intra-operative feature-based classification of microelectrode recordings to support the subthalamic nucleus functional identification during deep brain stimulation surgery.

    abstract：OBJECTIVE:The Subthalamic Nucleus (STN) is the most selected target for the placement of the Deep Brain Stimulation (DBS) electrode to treat Parkinson's disease. Its identification is a delicate and challenging task which is based on the interpretation of the STN functional activity acquired through microelectrode reco...

    journal_title：Journal of neural engineering

    pub_type： 杂志文章

    doi：10.1088/1741-2552/abcb15

    authors： Coelli S,Levi V,Del Vecchio Del Vecchio J,Mailland E,Rinaldo S,Eleopra R,Bianchi AM

    更新日期：2020-11-17 00:00:00