Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate.

Abstract:

OBJECTIVE:Analysis of intra- and perioperatively recorded cortical and basal ganglia local field potentials in human movement disorders has provided great insight into the pathophysiology of diseases such as Parkinson's, dystonia, and essential tremor. However, in order to better understand the network abnormalities and effects of chronic therapeutic stimulation in these disorders, long-term recording from a fully implantable data collection system is needed. APPROACH:A fully implantable investigational data collection system, the Activa® PC + S neurostimulator (Medtronic, Inc., Minneapolis, MN), has been developed for human use. Here, we tested its utility for extended intracranial recording in the motor system of a nonhuman primate. The system was attached to two quadripolar paddle arrays: one covering sensorimotor cortex, and one covering a proximal forelimb muscle, to study simultaneous cortical field potentials and electromyography during spontaneous transitions from rest to movement. MAIN RESULTS:Over 24 months of recording, movement-related changes in physiologically relevant frequency bands were readily detected, including beta and gamma signals at approximately 2.5 μV/[Formula: see text] and 0.7 μV/[Formula: see text], respectively. The system architecture allowed for flexible recording configurations and algorithm triggered data recording. In the course of physiological analyses, sensing artifacts were observed (∼1 μVrms stationary tones at fixed frequency), which were mitigated either with post-processing or algorithm design and did not impact the scientific conclusions. Histological examination revealed no underlying tissue damage; however, a fibrous capsule had developed around the paddles, demonstrating a potential mechanism for the observed signal amplitude reduction. SIGNIFICANCE:This study establishes the usefulness of this system in measuring chronic brain and muscle signals. Use of this system may potentially be valuable in human trials of chronic brain recording in movement disorders, a next step in the design of closed-loop neurostimulation paradigms.

journal_name

J Neural Eng

authors

Ryapolova-Webb E,Afshar P,Stanslaski S,Denison T,de Hemptinne C,Bankiewicz K,Starr PA

doi

10.1088/1741-2560/11/1/016009

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

016009

issue

1

eissn

1741-2560

issn

1741-2552

journal_volume

11

pub_type

杂志文章
  • Selective recovery of fascicular activity in peripheral nerves.

    abstract::The peripheral nerves of an amputee's residual limb still carry the information required to provide the robust, natural control signals needed to command a dexterous prosthetic limb. However, these signals are mixed in the volume conductor of the body and extracting them is an unmet challenge. A beamforming algorithm ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/8/5/056005

    authors: Wodlinger B,Durand DM

    更新日期:2011-10-01 00:00:00

  • Performance measurement for brain-computer or brain-machine interfaces: a tutorial.

    abstract:OBJECTIVE:Brain-computer interfaces (BCIs) have the potential to be valuable clinical tools. However, the varied nature of BCIs, combined with the large number of laboratories participating in BCI research, makes uniform performance reporting difficult. To address this situation, we present a tutorial on performance me...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/11/3/035001

    authors: Thompson DE,Quitadamo LR,Mainardi L,Laghari KU,Gao S,Kindermans PJ,Simeral JD,Fazel-Rezai R,Matteucci M,Falk TH,Bianchi L,Chestek CA,Huggins JE

    更新日期:2014-06-01 00:00:00

  • A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.

    abstract:OBJECTIVE:Neural reflexes regulate immune responses and homeostasis. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus n...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa7a42

    authors: Caravaca AS,Tsaava T,Goldman L,Silverman H,Riggott G,Chavan SS,Bouton C,Tracey KJ,Desimone R,Boyden ES,Sohal HS,Olofsson PS

    更新日期:2017-12-01 00:00:00

  • Electrophysiology-based detection of emergency braking intention in real-world driving.

    abstract:OBJECTIVE:The fact that all human action is preceded by brain processes partially observable through neuroimaging devices such as electroencephalography (EEG) is currently being explored in a number of applications. A recent study by Haufe et al (2011 J. Neural Eng. 8 056001) demonstrates the possibility of performing ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/11/5/056011

    authors: Haufe S,Kim JW,Kim IH,Sonnleitner A,Schrauf M,Curio G,Blankertz B

    更新日期:2014-10-01 00:00:00

  • HMM based automated wheelchair navigation using EOG traces in EEG.

    abstract::This paper presents a wheelchair navigation system based on a hidden Markov model (HMM), which we developed to assist those with restricted mobility. The semi-autonomous system is equipped with obstacle/collision avoidance sensors and it takes the electrooculography (EOG) signal traces from the user as commands to man...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/11/5/056018

    authors: Aziz F,Arof H,Mokhtar N,Mubin M

    更新日期:2014-10-01 00:00:00

  • Human-inspired sound environment recognition system for assistive vehicles.

    abstract:OBJECTIVE:The human auditory system acquires environmental information under sound stimuli faster than visual or touch systems, which in turn, allows for faster human responses to such stimuli. It also complements senses such as sight, where direct line-of-view is necessary to identify objects, in the environment recog...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/1/016012

    authors: Vidal EG,Zarricueta EF,Cheein FA

    更新日期:2015-02-01 00:00:00

  • Consistency of quantitative electroencephalography features in a large clinical data set.

    abstract:OBJECTIVE:Despite their increasing use and public health importance, little is known about the consistency and variability of the quantitative features of baseline electroencephalography (EEG) measurements in healthy individuals and populations. This study aims to investigate population consistency of EEG features. AP...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab4af3

    authors: Nahmias DO,Kontson KL,Soltysik DA,Civillico EF

    更新日期:2019-11-12 00:00:00

  • Validating biorobotic models.

    abstract::Some issues in neuroscience can be addressed by building robot models of biological sensorimotor systems. What we can conclude from building models or simulations, however, is determined by a number of factors in addition to the central hypothesis we intend to test. These include the way in which the hypothesis is rep...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2560/3/3/R01

    authors: Webb B

    更新日期:2006-09-01 00:00:00

  • Coarse behavioral context decoding.

    abstract:OBJECTIVE:Current brain-computer interface (BCI) studies demonstrate the potential to decode neural signals obtained from structured and trial-based tasks to drive actuators with high performance within the context of these tasks. Ideally, to maximize utility, such systems will be applied to a wide range of behavioral ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaee9c

    authors: Alasfour A,Gabriel P,Jiang X,Shamie I,Melloni L,Thesen T,Dugan P,Friedman D,Doyle W,Devinsky O,Gonda D,Sattar S,Wang S,Halgren E,Gilja V

    更新日期:2019-02-01 00:00:00

  • Data augmentation for self-paced motor imagery classification with C-LSTM.

    abstract:OBJECTIVE:Brain-computer interfaces (BCI) are becoming important tools for assistive technology, particularly through the use of motor imagery (MI) for aiding task completion. However, most existing methods of MI classification have been applied in a trial-wise fashion, with window sizes of approximately 2 s or more. A...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab57c0

    authors: Freer D,Yang GZ

    更新日期:2020-01-31 00:00:00

  • An intra-operative feature-based classification of microelectrode recordings to support the subthalamic nucleus functional identification during deep brain stimulation surgery.

    abstract:OBJECTIVE:The Subthalamic Nucleus (STN) is the most selected target for the placement of the Deep Brain Stimulation (DBS) electrode to treat Parkinson's disease. Its identification is a delicate and challenging task which is based on the interpretation of the STN functional activity acquired through microelectrode reco...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abcb15

    authors: Coelli S,Levi V,Del Vecchio Del Vecchio J,Mailland E,Rinaldo S,Eleopra R,Bianchi AM

    更新日期:2020-11-17 00:00:00

  • Evaluation of windowing techniques for intramuscular EMG-based diagnostic, rehabilitative and assistive devices.

    abstract:OBJECTIVE:Intramuscular electromyography (iEMG) signals, non-invasively recorded, directly from the muscles are used to diagnose various neuromuscular disorders/diseases, also to control rehabilitative and assistive robotic devices. iEMG signals are being potentially used in neurology, kinesiology, rehabilitation, and ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abcc7f

    authors: Ashraf H,Waris A,Gilani SO,Kashif AS,Jamil M,Jochumsen M,Niazi IK

    更新日期:2020-11-20 00:00:00

  • Modeling deep brain stimulation: point source approximation versus realistic representation of the electrode.

    abstract::Deep brain stimulation (DBS) has emerged as an effective treatment for movement disorders; however, the fundamental mechanisms by which DBS works are not well understood. Computational models of DBS can provide insights into these fundamental mechanisms and typically require two steps: calculation of the electrical po...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/7/6/066009

    authors: Zhang TC,Grill WM

    更新日期:2010-12-01 00:00:00

  • Algorithms and architectures for low power spike detection and alignment.

    abstract::We introduce algorithms and architectures for automatic spike detection and alignment that are designed for low power. Some of the algorithms are based on principal component analysis (PCA). Others employ a novel integral transform analysis and achieve 99% of the precision of a PCA detector, while requiring only 0.05%...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/3/1/004

    authors: Zviagintsev A,Perelman Y,Ginosar R

    更新日期:2006-03-01 00:00:00

  • Subspace-based interference removal methods for a multichannel biomagnetic sensor array.

    abstract:OBJECTIVE:In biomagnetic signal processing, the theory of the signal subspace has been applied to removing interfering magnetic fields, and a representative algorithm is the signal space projection algorithm, in which the signal/interference subspace is defined in the spatial domain as the span of signal/interference-s...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2552/aa7693

    authors: Sekihara K,Nagarajan SS

    更新日期:2017-10-01 00:00:00

  • Amplitude versus spatially modulated electrotactile feedback for myoelectric control of two degrees of freedom.

    abstract:OBJECTIVE:Artificial proprioceptive feedback from a myoelectric prosthesis is an important aspect in enhancing embodiment and user satisfaction, possibly lowering the demand for visual attention while controlling a prosthesis in everyday tasks. Contemporary myoelectric prostheses are advanced mechatronic systems with m...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aba4fd

    authors: Garenfeld MA,Mortensen CK,Strbac M,Dideriksen JL,Dosen S

    更新日期:2020-08-14 00:00:00

  • On robust parameter estimation in brain-computer interfacing.

    abstract:OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa8232

    authors: Samek W,Nakajima S,Kawanabe M,Müller KR

    更新日期:2017-12-01 00:00:00

  • Early seizure detection for closed loop direct neurostimulation devices in epilepsy.

    abstract::Current treatment concepts for epilepsy are based on continuous drug delivery or electrical stimulation to prevent the occurrence of seizures, exposing the brain and body to a mostly unneeded risk of adverse effects. To address the infrequent occurrence and short duration of epileptic seizures, intelligent implantable...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2552/ab094a

    authors: Dümpelmann M

    更新日期:2019-08-01 00:00:00

  • Single input optimal control for globally coupled neuron networks.

    abstract::We consider the problem of desynchronizing a network of synchronized, globally (all-to-all) coupled neurons using an input to a single neuron. This is done by applying the discrete time dynamic programming method to reduced phase models for neural populations. This technique numerically minimizes a certain cost functi...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/8/6/065008

    authors: Nabi A,Moehlis J

    更新日期:2011-12-01 00:00:00

  • Evoked haptic sensations in the hand via non-invasive proximal nerve stimulation.

    abstract:OBJECTIVE:Haptic perception of a prosthetic limb or hand is a crucial, but often unmet, need which impacts the utility of the prostheses. In this study, we seek to evaluate the feasibility of a non-invasive transcutaneous nerve stimulation method in generating haptic feedback in a transradial amputee subject as well as...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aabd5d

    authors: Shin H,Watkins Z,Huang HH,Zhu Y,Hu X

    更新日期:2018-08-01 00:00:00

  • Hyperparameter-tuned prediction of somatic symptom disorder using functional near-infrared spectroscopy-based dynamic functional connectivity.

    abstract:OBJECTIVE:Somatic symptom disorder (SSD) is a reflection of medically unexplained physical symptoms that lead to distress and impairment in social and occupational functioning. SSD is phenomenologically diagnosed and its neurobiology remains unsolved. APPROACH:In this study, we performed hyper-parameter optimized clas...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab50b2

    authors: Eken A,Çolak B,Bal NB,Kuşman A,Kızılpınar SÇ,Akaslan DS,Baskak B

    更新日期:2019-12-16 00:00:00

  • Inhibition of neuronal cell-cell adhesion measured by the microscopic aggregation assay and impedance sensing.

    abstract::Microscopic aggregation assay and impedance sensing (IS) were used to monitor a change in in vitro neuron-neuron adhesion in response to blocking of cell adhesion molecules. By blocking neuron-neuron adhesion, migration and aggregation of neuronal cells can be inhibited. This leads to better control of spatial arrange...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/7/5/056003

    authors: Wiertz RW,Marani E,Rutten WL

    更新日期:2010-10-01 00:00:00

  • Force estimation from ensembles of Golgi tendon organs.

    abstract::Golgi tendon organs (GTOs) located in the skeletal muscles provide the central nervous system with information about muscle tension. The ensemble firing of all GTO receptors in the muscle has been hypothesized to represent a reliable measure of the whole muscle force but the precision and accuracy of that information ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/3/036001

    authors: Mileusnic MP,Loeb GE

    更新日期:2009-06-01 00:00:00

  • Corrigendum: Tissue-engineered nerve grafts using a scaffold-independent and injectable drug delivery system: a novel design with translational advantages (2019 J. Neural Eng. 16 036030).

    abstract:OBJECTIVE:Currently commercially available nerve conduits have demonstrated suboptimal clinical efficacy in repairing peripheral nerve defects. Although tissue-engineered nerve grafts (TENGs) with sustained release of neurotrophic factors (NTFs) are experimentally proved to be more effective than these blank conduits, ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abd1ec

    authors: Liu Y,Yu S,Gu X,Cao R,Cui S

    更新日期:2020-12-09 00:00:00

  • A stationary wavelet transform and a time-frequency based spike detection algorithm for extracellular recorded data.

    abstract:OBJECTIVE:Spike detection from extracellular recordings is a crucial preprocessing step when analyzing neuronal activity. The decision whether a specific part of the signal is a spike or not is important for any kind of other subsequent preprocessing steps, like spike sorting or burst detection in order to reduce the c...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa654b

    authors: Lieb F,Stark HG,Thielemann C

    更新日期:2017-06-01 00:00:00

  • An improved P300 pattern in BCI to catch user's attention.

    abstract:OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa6213

    authors: Jin J,Zhang H,Daly I,Wang X,Cichocki A

    更新日期:2017-06-01 00:00:00

  • Lower layers in the motor cortex are more effective targets for penetrating microelectrodes in cortical prostheses.

    abstract::Improving cortical prostheses requires the development of recording neural interfaces that are efficient in terms of providing maximal control information with minimal interface complexity. While the typical approaches have targeted neurons in the motor cortex with multiple penetrating shanks, an alternative approach ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/2/026004

    authors: Parikh H,Marzullo TC,Kipke DR

    更新日期:2009-04-01 00:00:00

  • Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats.

    abstract:OBJECTIVE:Bladder dysfunction is a significant and largely unaddressed problem for people living with spinal cord injury. Intermittent catheterization does not provide volitional control of micturition and has numerous side effects. Targeted electrical microstimulation of the spinal cord has been previously explored fo...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abca13

    authors: Pikov V,McCreery DB,Han M

    更新日期:2020-11-12 00:00:00

  • Reconstruction of post-synaptic potentials by reverse modeling of local field potentials.

    abstract:OBJECTIVE:Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. In cortic...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aafbfb

    authors: Yochum M,Modolo J,Mogul DJ,Benquet P,Wendling F

    更新日期:2019-04-01 00:00:00

  • Decoding overt shifts of attention in depth through pupillary and cortical frequency tagging.

    abstract:OBJECTIVE:We have recently developed a prototype of a novel human-computer interface for assistive communication based on voluntary shifts of attention (gaze) from a far target to a near target associated with a decrease of pupil size (Pupillary Accommodative Response, PAR), an automatic vegetative response that can be...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab8e8f

    authors: de'Sperati C,Roatta S,Zovetti N,Baroni T

    更新日期:2020-04-29 00:00:00