Suppression of scarring in peripheral nerve implants by drug elution.

abstract：OBJECTIVE:Brain-machine interfaces (BMIs) have been proposed in closed-loop applications for neuromodulation and neurorehabilitation. This study describes the impact of different feedback modalities on the performance of an EEG-based BMI that decodes motor imagery (MI) of leg flexion and extension. APPROACH:We execute...

journal_title：Journal of neural engineering

authors： Liu D,Chen W,Lee K,Chavarriaga R,Bouri M,Pei Z,Del R Millán J

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Brain-computer interfaces (BCIs) implemented with real-time functional magnetic resonance imaging (rt-fMRI) use fMRI time-courses from predefined regions of interest (ROIs). To reach best performances, localizer experiments and on-site expert supervision are required for ROI definition. To automate this step,...

journal_title：Journal of neural engineering

authors： Lührs M,Sorger B,Goebel R,Esposito F

更新日期：2017-02-01 00:00:00

abstract：UNLABELLED:Transcranial Doppler (TCD) was recently introduced as a new brain-computer interface (BCI) modality for detecting task-induced hemispheric lateralization. To date, single-trial discrimination between a lateralized mental activity and a rest state has been demonstrated with long (45 s) activation time periods...

journal_title：Journal of neural engineering

authors： Aleem I,Chau T

更新日期：2013-02-01 00:00:00

abstract：:Significant progress has been made in systems that interpret the electrical signals of the brain in order to control an actuator. One version of these systems senses neuronal extracellular action potentials with an array of up to 100 miniature probes inserted into the cortex. The impedance of each probe is high, so en...

journal_title：Journal of neural engineering

authors： Jochum T,Denison T,Wolf P

更新日期：2009-02-01 00:00:00

abstract：:This paper presents a wheelchair navigation system based on a hidden Markov model (HMM), which we developed to assist those with restricted mobility. The semi-autonomous system is equipped with obstacle/collision avoidance sensors and it takes the electrooculography (EOG) signal traces from the user as commands to man...

journal_title：Journal of neural engineering

authors： Aziz F,Arof H,Mokhtar N,Mubin M

更新日期：2014-10-01 00:00:00

abstract：:The modern multi-channel cochlear implant is widely considered to be the most successful neural prosthesis owing to its ability to restore partial hearing to post-lingually deafened adults and to allow essentially normal language development in pre-lingually deafened children. However, the implant performance varies g...

journal_title：Journal of neural engineering

authors： Tang Q,Benítez R,Zeng FG

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Due to their increased proximity to retinal ganglion cells (RGCs), epiretinal visual prostheses present the opportunity for eliciting phosphenes with low thresholds through direct RGC activation. This study characterised the in vivo performance of a novel prototype monolithic epiretinal prosthesis, containing...

journal_title：Journal of neural engineering

authors： Shivdasani MN,Evans M,Burns O,Yeoh J,Allen PJ,Nayagam DAX,Villalobos J,Abbott CJ,Luu CD,Opie NL,Sabu A,Saunders AL,McPhedran M,Cardamone L,McGowan C,Maxim V,Williams RA,Fox KE,Cicione R,Garrett DJ,Ahnood A,Ganes

更新日期：2020-08-05 00:00:00

abstract：OBJECTIVE:A signal-based metric for assessment of accuracy of motor unit (MU) identification from high-density surface electromyograms (EMG) is introduced. This metric, so-called pulse-to-noise-ratio (PNR), is computationally efficient, does not require any additional experimental costs and can be applied to every MU t...

journal_title：Journal of neural engineering

authors： Holobar A,Minetto MA,Farina D

更新日期：2014-02-01 00:00:00

abstract：:The objective of this work is to develop and test a photovoltaic retinal prosthesis for restoring sight to patients blinded by degenerative retinal diseases. A silicon photodiode array for subretinal stimulation has been fabricated by a silicon-integrated-circuit/MEMS process. Each pixel in the two-dimensional array c...

journal_title：Journal of neural engineering

authors： Wang L,Mathieson K,Kamins TI,Loudin JD,Galambos L,Goetz G,Sher A,Mandel Y,Huie P,Lavinsky D,Harris JS,Palanker DV

更新日期：2012-08-01 00:00:00

abstract：:Corrosion is a prime concern for active implantable devices. In this paper we review the principles underlying the concepts of hermetic packages and encapsulation, used to protect implanted electronics, some of which remain widely overlooked. We discuss how technological advances have created a need to update the way ...

journal_title：Journal of neural engineering

authors： Vanhoestenberghe A,Donaldson N

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:We have recently developed a prototype of a novel human-computer interface for assistive communication based on voluntary shifts of attention (gaze) from a far target to a near target associated with a decrease of pupil size (Pupillary Accommodative Response, PAR), an automatic vegetative response that can be...

journal_title：Journal of neural engineering

authors： de'Sperati C,Roatta S,Zovetti N,Baroni T

更新日期：2020-04-29 00:00:00

abstract：OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...

journal_title：Journal of neural engineering

authors： Samek W,Nakajima S,Kawanabe M,Müller KR

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:For intracortical brain-machine interfaces (BMIs), action potential voltage waveforms are often sorted to separate out individual neurons. If these neurons contain independent tuning information, this process could increase BMI performance. However, the sorting of action potentials ('spikes') requires high sa...

journal_title：Journal of neural engineering

authors： Christie BP,Tat DM,Irwin ZT,Gilja V,Nuyujukian P,Foster JD,Ryu SI,Shenoy KV,Thompson DE,Chestek CA

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Fractional calculus plays a key role in the analysis of neural dynamics. In particular, fractional calculus has been recently exploited for analyzing complex biological systems and capturing intrinsic phenomena. Also, artificial neural networks have been shown to have complex neuronal dynamics and characteris...

journal_title：Journal of neural engineering

authors： Lu Q

更新日期：2020-06-12 00:00:00

abstract：OBJECTIVE:There has recently been an increasing interest in local field potential (LFP) for brain-machine interface (BMI) applications due to its desirable properties (signal stability and low bandwidth). LFP is typically recorded with respect to a single unipolar reference which is susceptible to common noise. Several...

journal_title：Journal of neural engineering

authors： Ahmadi N,Constandinou T,Bouganis CS

更新日期：2020-11-26 00:00:00

abstract：:Functional electrical stimulation (FES), the coordinated electrical activation of multiple muscles, has been used to restore arm and hand function in people with paralysis. User interfaces for such systems typically derive commands from mechanically unrelated parts of the body with retained volitional control, and are...

journal_title：Journal of neural engineering

authors： Chadwick EK,Blana D,Simeral JD,Lambrecht J,Kim SP,Cornwell AS,Taylor DM,Hochberg LR,Donoghue JP,Kirsch RF

更新日期：2011-06-01 00:00:00

abstract：:Electrical stimulation of peripheral nerve activates large-diameter fibers before small ones. A physiological recruitment order, from small to large-diameter axons, is desirable in many applications. Previous studies using computer simulations showed that selective activation of small fibers could be achieved by resha...

journal_title：Journal of neural engineering

authors： Lertmanorat Z,Durand DM

更新日期：2004-12-01 00:00:00

abstract：:Deep brain stimulation (DBS) has emerged as an effective treatment for movement disorders; however, the fundamental mechanisms by which DBS works are not well understood. Computational models of DBS can provide insights into these fundamental mechanisms and typically require two steps: calculation of the electrical po...

journal_title：Journal of neural engineering

authors： Zhang TC,Grill WM

更新日期：2010-12-01 00:00:00

abstract：:Neural activity can be modulated by applying a polarizing low-frequency (<100 Hz) electric field (PLEF). Unlike conventional pulsed stimulation, PLEF stimulation has a graded, modulatory effect on neuronal excitability, and permits the simultaneous recording of neuronal activity during stimulation suitable for continu...

journal_title：Journal of neural engineering

authors： Sunderam S,Chernyy N,Peixoto N,Mason JP,Weinstein SL,Schiff SJ,Gluckman BJ

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:We presented a comparative study on the training methodologies of a convolutional neural network (CNN) for the detection of steady-state visually evoked potentials (SSVEP). Two training scenarios were also compared: user-independent (UI) training and user-dependent (UD) training. APPROACH:The CNN was trained...

journal_title：Journal of neural engineering

authors： Ravi A,Beni NH,Manuel J,Jiang N

更新日期：2020-04-08 00:00:00

abstract：OBJECTIVE:This paper discusses the invariance and variability in interaction error-related potentials (ErrPs), where a special focus is laid upon the factors of (1) the human mental processing required to assess interface actions (2) time (3) subjects. APPROACH:Three different experiments were designed as to vary prim...

journal_title：Journal of neural engineering

authors： Abu-Alqumsan M,Kapeller C,Hintermüller C,Guger C,Peer A

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To determine whether the estimated fraction and degree of distribution of visual responsive neurons in human intracranial microwire recordings depends upon the spike sorting method used. APPROACH:A large dataset of human intracranial microwire recordings from four brain areas was sorted into single unit acti...

journal_title：Journal of neural engineering

authors： Steinmetz PN

更新日期：2020-04-09 00:00:00

abstract：:Retinal implants have proven their ability to restore visual sensation to people with degenerative retinopathy, characterized by photoreceptor cell death and the retina's inability to sense light. Retinal bionics operate by electrically stimulating the surviving neurons in the retina, thus triggering the transfer of v...

journal_title：Journal of neural engineering

authors： Bareket L,Barriga-Rivera A,Zapf MP,Lovell NH,Suaning GJ

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Two-dimensional (2D) movement control is an important issue in brain-computer interfaces (BCIs) research because being able to move, for example, a cursor with the brain will enable patients with motor disabilities to control their environment. However, it is still a challenge to continuously control 2D movem...

journal_title：Journal of neural engineering

authors： Xia B,Maysam O,Veser S,Cao L,Li J,Jia J,Xie H,Birbaumer N

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. AP...

journal_title：Journal of neural engineering

authors： Barragan A,Preston C,Alvarez A,Bera T,Qin Y,Weinand M,Kasoff W,Witte RS

更新日期：2020-10-30 00:00:00

abstract：OBJECTIVE:Low-intensity transcranial ultrasound stimulation (TUS) is emerging as a non-invasive brain stimulation technique with superior spatial resolution and the ability to reach deep brain areas. Medical image-based computational modeling could be an important tool for individualized TUS dose control and targeting ...

journal_title：Journal of neural engineering

authors： Pasquinelli C,Montanaro H,Lee HJ,Hanson LG,Kim H,Kuster N,Siebner HR,Neufeld E,Thielscher A

更新日期：2020-07-13 00:00:00

abstract：OBJECTIVE:Multimodal neuroimaging approaches are beneficial to discover brain functionalities at high spatial and temporal resolution. In our work, a novel material composition of a microECoG device relying on Parylene HT and indium-tin-oxide (ITO) is presented, which facilitates two-photon imaging of Ca2+ signals and ...

journal_title：Journal of neural engineering

authors： Zátonyi A,Madarász M,Szabó Á,Lőrincz T,Hodován R,Rózsa B,Fekete Z

更新日期：2020-02-18 00:00:00

abstract：OBJECTIVE:Over the past two decades retinal prostheses have made major strides in restoring functional vision to patients blinded by diseases such as retinitis pigmentosa. Presently, implants use single pulses to activate the retina. Though this stimulation paradigm has proved beneficial to patients, an unresolved prob...

journal_title：Journal of neural engineering

authors： Sekhar S,Jalligampala A,Zrenner E,Rathbun DL

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Dry electrodes have an advantage over gel-based 'wet' electrodes by providing quicker set-up time for electroencephalography recording; however, the potentially poorer contact can result in noisier recordings. We examine the impact that this may have on brain-computer interface communication and potential app...

journal_title：Journal of neural engineering

authors： Clements JM,Sellers EW,Ryan DB,Caves K,Collins LM,Throckmorton CS

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Most brain-computer interfaces (BCIs) based on functional near-infrared spectroscopy (fNIRS) require that users perform mental tasks such as motor imagery, mental arithmetic, or music imagery to convey a message or to answer simple yes or no questions. These cognitive tasks usually have no direct association ...

journal_title：Journal of neural engineering

authors： Rezazadeh Sereshkeh A,Yousefi R,Wong AT,Chau T

更新日期：2019-02-01 00:00:00