Abstract:
OBJECTIVE:To determine whether the estimated fraction and degree of distribution of visual responsive neurons in human intracranial microwire recordings depends upon the spike sorting method used. APPROACH:A large dataset of human intracranial microwire recordings from four brain areas was sorted into single unit activity (SUA) and multiunit activity (MUA) using 4 spike sorting methods previously applied to this type of recording. The responses were examined for visual responses to 33 objects which were presented. MAIN RESULTS:The 4 spike sorting techniques examined here yielded fractions of responsive SUA varying from 8% in the left anterior cingulate cortex to 27% in the right amgdala. The fraction of responsive SUA and MUA depended on the type of spike sorting being used as well as brain area and side being recorded from. Agreement between spike sorting techniques was low (0.04-0.16 on the 0-1 AMIall scale). SIGNIFICANCE:Prior estimates of the fraction of single neurons in the human medial temporal lobe coding semantic memory of visual objects have yielded fractions ranging from 0.04% by very strict response criteria to 47% by other criteria. A variety of explanations of these differences have been posited, including differences in the type of memory being tested, differences in visual stimuli, as well as technical differences such as spike sorting techniques. This study shows the dependence of the reported fraction of neurons encoding visual objects on the spike sorting technique employed and confirms a distributed representation of visual objects by single neurons in the human brain. Both the variation in the responsive fractions with spike sorting technique and low levels of agreement between techniques highlight the need for better understanding of the signals being extracted in human intracranial microwire recordings.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Steinmetz PNdoi
10.1088/1741-2552/ab6cb8subject
Has Abstractpub_date
2020-04-09 00:00:00pages
026030issue
2eissn
1741-2560issn
1741-2552journal_volume
17pub_type
杂志文章abstract::In this paper we propose a dual stream neural network (DSNN) for classifying arbitrary collections of functional neuroimaging signals for the purpose of brain computer interfaces (BCIs). In the DSNN the first stream is an end-to-end classifier taking raw time-dependent signals as input and generating feature identific...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abc903
更新日期:2020-11-10 00:00:00
abstract:OBJECTIVE:One of the main goals of brain-machine interface (BMI) research is to restore function to people with paralysis. Currently, multiple BMI design features are being investigated, based on various input modalities (externally applied and surgically implantable sensors) and output modalities (e.g. control of comp...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/4/043002
更新日期:2015-08-01 00:00:00
abstract::Brain-computer interfaces (BCIs) can use brain signals from the scalp (EEG), the cortical surface (ECoG), or within the cortex to restore movement control to people who are paralyzed. Like muscle-based skills, BCIs' use requires activity-dependent adaptations in the brain that maintain stable relationships between the...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/3/036007
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the use of muscles appropriate for partial-hand prostheses with those typically used for complete hand devices and to determine whether differences in their underlying neural substrates translate to different levels of myoelectric control. APPROACH:We developed a no...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aacbfe
更新日期:2018-10-01 00:00:00
abstract::Brain-computer interface (BCI) systems do not work for all users. This article introduces a novel combination of tasks that could inspire BCI systems that are more accurate than conventional BCIs, especially for users who cannot attain accuracy adequate for effective communication. Subjects performed tasks typically u...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/2/026007
更新日期:2010-04-01 00:00:00
abstract::A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/3/036009
更新日期:2012-06-01 00:00:00
abstract::Improving cortical prostheses requires the development of recording neural interfaces that are efficient in terms of providing maximal control information with minimal interface complexity. While the typical approaches have targeted neurons in the motor cortex with multiple penetrating shanks, an alternative approach ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/2/026004
更新日期:2009-04-01 00:00:00
abstract::Functional electrical stimulation (FES), the coordinated electrical activation of multiple muscles, has been used to restore arm and hand function in people with paralysis. User interfaces for such systems typically derive commands from mechanically unrelated parts of the body with retained volitional control, and are...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/3/034003
更新日期:2011-06-01 00:00:00
abstract::In this work the application of different machine learning techniques for classification of mental tasks from electroencephalograph (EEG) signals is investigated. The main application for this research is the improvement of brain computer interface (BCI) systems. For this purpose, Bayesian graphical network, neural ne...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/3/2/008
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6213
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Recording of neural signals from intact peripheral nerves in patients with spinal cord injury or stroke survivors offers the possibility for the development of closed-loop sensorimotor prostheses. Nerve cuffs have been found to provide stable recordings from peripheral nerves for prolonged periods of time. Ho...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aabca0
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:When developing approaches for automatic preprocessing of electroencephalogram (EEG) signals in non-isolated demanding environment such as intensive care unit (ICU) or even outdoor environment, one of the major concerns is varying nature of characteristics of different artifacts in time, frequency and spatial...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abb5bd
更新日期:2020-10-15 00:00:00
abstract::The gait outcome measures used in clinical trials of paraplegic locomotor training determine the effectiveness of improved walking function assisted by the functional electrical stimulation (FES) system. Focused on kinematic, kinetic or physiological changes of paraplegic patients, traditional methods cannot quantify ...
journal_title:Journal of neural engineering
pub_type: 临床试验,杂志文章
doi:10.1088/1741-2560/6/6/066007
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Real-time closed-loop neural feedback control requires the analysis of action potential traces within several milliseconds after they have been recorded from the brain. The current generation of spike clustering algorithms were mostly designed for off-line use and also require a significant amount of computat...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab208c
更新日期:2019-07-30 00:00:00
abstract:OBJECTIVE:This paper discusses the invariance and variability in interaction error-related potentials (ErrPs), where a special focus is laid upon the factors of (1) the human mental processing required to assess interface actions (2) time (3) subjects. APPROACH:Three different experiments were designed as to vary prim...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa8416
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:When designing multiclass motor imagery-based brain-computer interface (MI-BCI), a so-called tangent space mapping (TSM) method utilizing the geometric structure of covariance matrices is an effective technique. This paper aims to introduce a method using TSM for finding accurate operational frequency bands r...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aac313
更新日期:2018-08-01 00:00:00
abstract::All of the human prosthetic visual systems implanted so far have been achromatic. Schmidt et al. (1996) reported that at low stimulation intensities their subject reported that phosphenes usually had a specific hue, but when the stimulus intensity was increased, they desaturated to white. We speculate here that previo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abd520
更新日期:2020-12-18 00:00:00
abstract::The functional effects of selective hypoglossal nerve (HG) stimulation with a multi-contact peripheral nerve electrode were assessed using images of the upper airways and the tongue in anesthetized beagles. A biphasic pulse train of 50 Hz frequency and 2 s duration was applied through each one of the tripolar contact ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/2/4/002
更新日期:2005-12-01 00:00:00
abstract::Deep brain stimulation (DBS) has emerged as an effective treatment for movement disorders; however, the fundamental mechanisms by which DBS works are not well understood. Computational models of DBS can provide insights into these fundamental mechanisms and typically require two steps: calculation of the electrical po...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/6/066009
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:While the positive correlation between impedance and noise of microelectrodes is well known, their quantitative relationship is too rarely described. Knowledge of this relationship provides useful information for both microsystems engineers and electrophysiologists. APPROACH:We discuss the physical basis of ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abb3b4
更新日期:2020-10-15 00:00:00
abstract:OBJECTIVE:Retinal prosthetic implants restore partial vision to patients blinded due to outer retinal degeneration, using a camera-guided multielectrode array (MEA) that electrically stimulates surviving retinal neurons. Commercial epi-retinal prostheses use millisecond-scale charge-balanced, symmetric, cathodic-first ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf92b
更新日期:2019-04-01 00:00:00
abstract::In the study of the spreading depression (SD) wave phenomenon and its dynamics, it is necessary to describe the ionic movements along the extracellular space, as well as between this and the intracellular space. In both cases, the ionic movement includes a double coupling involving the concentration and the potential ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/1/2/007
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:Penetrating cortical neural probe technologies allow investigators to record electrical signals in the brain. Implantation of probes results in acute tissue damage, and microglia density increases around implanted devices over weeks. However, the mechanisms underlying this encapsulation are not well understoo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/6/066001
更新日期:2012-12-01 00:00:00
abstract::To properly observe induced connectivity changes after training sessions, one needs a network model that describes individual relationships in sufficient detail to enable observation of induced changes and yet reveals some kind of stability in these relationships. We analyzed spontaneous firing activity in dissociated...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/2/006
更新日期:2007-06-01 00:00:00
abstract::Implantable electrode arrays capable of recording and stimulating neural activity with high spatial and temporal resolution will provide a foundation for future brain computer interface technology. Currently, their clinical impact has been curtailed by a general lack of functional stability, which can be attributed to...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/4/003
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Electrocorticography (ECoG) based studies generally analyze features from specific frequency bands selected by manual evaluation of spectral power. However, the definition of these features can vary across subjects, cortical areas, tasks and across time for a given subject. We propose an autoencoder based app...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf13f
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Given current clinical interest in vagus nerve stimulation (VNS), there are surprisingly few studies characterizing the anatomy of the vagus nerve in large animal models as it pertains to on-and off-target engagement of local fibers. We sought to address this gap by evaluating vagal anatomy in the pig, whose ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab7ad4
更新日期:2020-04-09 00:00:00
abstract::Some issues in neuroscience can be addressed by building robot models of biological sensorimotor systems. What we can conclude from building models or simulations, however, is determined by a number of factors in addition to the central hypothesis we intend to test. These include the way in which the hypothesis is rep...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/3/3/R01
更新日期:2006-09-01 00:00:00
abstract::Golgi tendon organs (GTOs) located in the skeletal muscles provide the central nervous system with information about muscle tension. The ensemble firing of all GTO receptors in the muscle has been hypothesized to represent a reliable measure of the whole muscle force but the precision and accuracy of that information ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/3/036001
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Visual prostheses are designed to restore partial functional vision in patients with total vision loss. Retinal visual prostheses provide limited capabilities as a result of low resolution, limited field of view and poor dynamic range. Understanding the influence of these parameters in the perception results ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abb9be
更新日期:2020-10-08 00:00:00