Dilation of the oropharynx via selective stimulation of the hypoglossal nerve.

Abstract:

:The functional effects of selective hypoglossal nerve (HG) stimulation with a multi-contact peripheral nerve electrode were assessed using images of the upper airways and the tongue in anesthetized beagles. A biphasic pulse train of 50 Hz frequency and 2 s duration was applied through each one of the tripolar contact sets of the nerve electrode while the pharyngeal images were acquired into a computer. The stimulation current was limited to 20% above the activation threshold for maximum selectivity. The images showed that various contact sets could generate several different activation patterns of the tongue muscles resulting in medial and/or lateral dilation and closing of the airways at the tongue root. Some of these patterns translated into an increase in the oropharyngeal size while others did not have any effect. The pharyngeal sizes were not statistically different during stimulation either between the two different positions of the head (30 degrees and 60 degrees), or when the lateral contacts were compared with the medial ones. The contacts that had the least effect generated an average of 53 +/- 15% pharyngeal dilation relative to the best contacts, indicating that the results are marginally sensitive to the contact position around the HG nerve trunk. These results suggest that selective HG nerve stimulation can be a useful technique to produce multiple tongue activation patterns that can dilate the pharynx. This may in turn increase the size of the patient population who can benefit from HG nerve stimulation as a treatment method for obstructive sleep apnea.

journal_name

J Neural Eng

authors

Huang J,Sahin M,Durand DM

doi

10.1088/1741-2560/2/4/002

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

73-80

issue

4

eissn

1741-2560

issn

1741-2552

pii

S1741-2560(05)94325-5

journal_volume

2

pub_type

杂志文章
  • Speech stream segregation to control an ERP-based auditory BCI.

    abstract:OBJECTIVE:The use of natural sounds in auditory Brain-Computer Interfaces (BCI) has been shown to improve classification results and usability. Some auditory BCIs are based on stream segregation, in which the subjects must attend one audio stream and ignore the other(s); these streams include some kind of stimuli to be...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abdd44

    authors: Velasco-Álvarez F,Fernández-Rodríguez Á,Medina-Juliá MT,Ron-Angevin R

    更新日期:2021-01-19 00:00:00

  • On the risk of extracting relevant information from random data.

    abstract::This comment constitutes a re-assessment of a recent study in which near-infrared spectroscopy (NIRS) was used to decode decision making. In the original study, the process of feature selection was carried out on all of the data, and those features which displayed the greater classification accuracy were selected, but...

    journal_title:Journal of neural engineering

    pub_type: 评论,杂志文章

    doi:10.1088/1741-2560/6/5/058001

    authors: Dominguez LG

    更新日期:2009-10-01 00:00:00

  • HMM based automated wheelchair navigation using EOG traces in EEG.

    abstract::This paper presents a wheelchair navigation system based on a hidden Markov model (HMM), which we developed to assist those with restricted mobility. The semi-autonomous system is equipped with obstacle/collision avoidance sensors and it takes the electrooculography (EOG) signal traces from the user as commands to man...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/11/5/056018

    authors: Aziz F,Arof H,Mokhtar N,Mubin M

    更新日期:2014-10-01 00:00:00

  • Real-time cerebellar neuroprosthetic system based on a spiking neural network model of motor learning.

    abstract:OBJECTIVE:Damage to the brain, as a result of various medical conditions, impacts the everyday life of patients and there is still no complete cure to neurological disorders. Neuroprostheses that can functionally replace the damaged neural circuit have recently emerged as a possible solution to these problems. Here we ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa98e9

    authors: Xu T,Xiao N,Zhai X,Kwan Chan P,Tin C

    更新日期:2018-02-01 00:00:00

  • CO2 sensitivity of the complexity of phrenic neurograms in the piglet during early maturation.

    abstract::In this paper, we investigate the influence of hypercapnia on the dynamics of the phrenic neurogram in the piglet in two different age groups: 3-7 days (n = 11) and 10-16 days (n = 9). The phrenic neurogram was recorded from 17 piglets (3-16 days old) during control (40% O(2) with 3-5% end-tidal CO(2)), mild hypercapn...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/2/2/004

    authors: Akay M

    更新日期:2005-06-01 00:00:00

  • Towards a hemodynamic BCI using transcranial Doppler without user-specific training data.

    abstract:UNLABELLED:Transcranial Doppler (TCD) was recently introduced as a new brain-computer interface (BCI) modality for detecting task-induced hemispheric lateralization. To date, single-trial discrimination between a lateralized mental activity and a rest state has been demonstrated with long (45 s) activation time periods...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/1/016005

    authors: Aleem I,Chau T

    更新日期:2013-02-01 00:00:00

  • A neurorobotic platform for locomotor prosthetic development in rats and mice.

    abstract:OBJECTIVES:We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. APPROACH:We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules e...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/2/026007

    authors: von Zitzewitz J,Asboth L,Fumeaux N,Hasse A,Baud L,Vallery H,Courtine G

    更新日期:2016-04-01 00:00:00

  • Intrinsic optical signal imaging of the blood volume changes is sufficient for mapping the resting state functional connectivity in the rodent cortex.

    abstract:OBJECTIVE:Resting state functional connectivity (RSFC) allows the study of functional organization in normal and diseased brain by measuring the spontaneous brain activity generated under resting conditions. Intrinsic optical signal imaging (IOSI) based on multiple illumination wavelengths has been used successfully to...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaafe4

    authors: Kura S,Xie H,Fu B,Ayata C,Boas DA,Sakadžić S

    更新日期:2018-06-01 00:00:00

  • Toward a hybrid brain-computer interface based on imagined movement and visual attention.

    abstract::Brain-computer interface (BCI) systems do not work for all users. This article introduces a novel combination of tasks that could inspire BCI systems that are more accurate than conventional BCIs, especially for users who cannot attain accuracy adequate for effective communication. Subjects performed tasks typically u...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/7/2/026007

    authors: Allison BZ,Brunner C,Kaiser V,Müller-Putz GR,Neuper C,Pfurtscheller G

    更新日期:2010-04-01 00:00:00

  • Intraneural sensory feedback restores grip force control and motor coordination while using a prosthetic hand.

    abstract:OBJECTIVE:Tactile afferents in the human hand provide fundamental information about hand-environment interactions, which is used by the brain to adapt the motor output to the physical properties of the object being manipulated. A hand amputation disrupts both afferent and efferent pathways from/to the hand, completely ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,随机对照试验

    doi:10.1088/1741-2552/ab059b

    authors: Clemente F,Valle G,Controzzi M,Strauss I,Iberite F,Stieglitz T,Granata G,Rossini PM,Petrini F,Micera S,Cipriani C

    更新日期:2019-04-01 00:00:00

  • Decoding natural reach-and-grasp actions from human EEG.

    abstract:OBJECTIVE:Despite the high number of degrees of freedom of the human hand, most actions of daily life can be executed incorporating only palmar, pincer and lateral grasp. In this study we attempt to discriminate these three different executed reach-and-grasp actions utilizing their EEG neural correlates. APPROACH:In a...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa8911

    authors: Schwarz A,Ofner P,Pereira J,Sburlea AI,Müller-Putz GR

    更新日期:2018-02-01 00:00:00

  • Comparison of spike sorting and thresholding of voltage waveforms for intracortical brain-machine interface performance.

    abstract:OBJECTIVE:For intracortical brain-machine interfaces (BMIs), action potential voltage waveforms are often sorted to separate out individual neurons. If these neurons contain independent tuning information, this process could increase BMI performance. However, the sorting of action potentials ('spikes') requires high sa...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/1/016009

    authors: Christie BP,Tat DM,Irwin ZT,Gilja V,Nuyujukian P,Foster JD,Ryu SI,Shenoy KV,Thompson DE,Chestek CA

    更新日期:2015-02-01 00:00:00

  • Hardware architecture for real-time EEG-based functional brain connectivity parameter extraction.

    abstract::In this work, we proposed a novel architecture for real-time quantitative characterization of functional brain connectivity networks derived from Electroencephalogram (EEG). It consists of two main parts - calculation of Phase Lag Index (PLI) to form the functional connectivity networks and the extraction of a set of ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abd462

    authors: Gutierrez Nuno RA,Chung CHR,Maharatna K

    更新日期:2020-12-16 00:00:00

  • Feasibility of differentially measuring afferent and efferent neural activity with a single nerve cuff electrode.

    abstract:OBJECTIVE:Advances in electrode technology have facilitated the development of neuroprostheses for restoring motor/sensory function in disabled individuals. Information extracted from a whole nerve, recorded using cuffs, can provide signals that control the operation of neuroprostheses. However, the amount of informati...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab5551

    authors: Sabetian P,Yoo PB

    更新日期:2020-01-28 00:00:00

  • VITA-an everyday virtual reality setup for prosthetics and upper-limb rehabilitation.

    abstract:OBJECTIVE:Currently, there are some 95 000 people in Europe suffering from upper-limb impairment. Rehabilitation should be undertaken right after the impairment occurs and should be regularly performed thereafter. Moreover, the rehabilitation process should be tailored specifically to both patient and impairment. APPR...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaf35f

    authors: Nissler C,Nowak M,Connan M,Büttner S,Vogel J,Kossyk I,Márton ZC,Castellini C

    更新日期:2019-04-01 00:00:00

  • The statistical distribution of noisy transmission in human sensors.

    abstract:OBJECTIVE:Brains, like other physical devices, are inherently noisy. This source of variability is large, to the extent that internal noise often impacts human sensory processing more than externally induced (stimulus-driven) perturbations. Despite the fundamental nature of this phenomenon, its statistical distribution...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,随机对照试验

    doi:10.1088/1741-2560/10/1/016014

    authors: Neri P

    更新日期:2013-02-01 00:00:00

  • Multiresolution analysis over simple graphs for brain computer interfaces.

    abstract:OBJECTIVE:Multiresolution analysis (MRA) offers a useful framework for signal analysis in the temporal and spectral domains, although commonly employed MRA methods may not be the best approach for brain computer interface (BCI) applications. This study aims to develop a new MRA system for extracting tempo-spatial-spect...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/4/046014

    authors: Asensio-Cubero J,Gan JQ,Palaniappan R

    更新日期:2013-08-01 00:00:00

  • Altered electroencephalography functional connectivity in depression during the emotional face-word Stroop task.

    abstract:OBJECTIVE:Depression is a severe mental disorder. However, the neural mechanisms underlying affective interference (difficulties in directing attention away from negative distractors) in depression patients are still not well-understood. In particular, the connections between brain regions remain unclear. Using the emo...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aacdbb

    authors: Guo Z,Wu X,Liu J,Yao L,Hu B

    更新日期:2018-10-01 00:00:00

  • An intra-operative feature-based classification of microelectrode recordings to support the subthalamic nucleus functional identification during deep brain stimulation surgery.

    abstract:OBJECTIVE:The Subthalamic Nucleus (STN) is the most selected target for the placement of the Deep Brain Stimulation (DBS) electrode to treat Parkinson's disease. Its identification is a delicate and challenging task which is based on the interpretation of the STN functional activity acquired through microelectrode reco...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abcb15

    authors: Coelli S,Levi V,Del Vecchio Del Vecchio J,Mailland E,Rinaldo S,Eleopra R,Bianchi AM

    更新日期:2020-11-17 00:00:00

  • Evaluation of windowing techniques for intramuscular EMG-based diagnostic, rehabilitative and assistive devices.

    abstract:OBJECTIVE:Intramuscular electromyography (iEMG) signals, non-invasively recorded, directly from the muscles are used to diagnose various neuromuscular disorders/diseases, also to control rehabilitative and assistive robotic devices. iEMG signals are being potentially used in neurology, kinesiology, rehabilitation, and ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abcc7f

    authors: Ashraf H,Waris A,Gilani SO,Kashif AS,Jamil M,Jochumsen M,Niazi IK

    更新日期:2020-11-20 00:00:00

  • Lower layers in the motor cortex are more effective targets for penetrating microelectrodes in cortical prostheses.

    abstract::Improving cortical prostheses requires the development of recording neural interfaces that are efficient in terms of providing maximal control information with minimal interface complexity. While the typical approaches have targeted neurons in the motor cortex with multiple penetrating shanks, an alternative approach ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/2/026004

    authors: Parikh H,Marzullo TC,Kipke DR

    更新日期:2009-04-01 00:00:00

  • Different classification techniques considering brain computer interface applications.

    abstract::In this work the application of different machine learning techniques for classification of mental tasks from electroencephalograph (EEG) signals is investigated. The main application for this research is the improvement of brain computer interface (BCI) systems. For this purpose, Bayesian graphical network, neural ne...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/3/2/008

    authors: Rezaei S,Tavakolian K,Nasrabadi AM,Setarehdan SK

    更新日期:2006-06-01 00:00:00

  • The development of neural stimulators: a review of preclinical safety and efficacy studies.

    abstract:OBJECTIVE:Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technolog...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aac43c

    authors: Shepherd RK,Villalobos J,Burns O,Nayagam DAX

    更新日期:2018-08-01 00:00:00

  • Computationally inexpensive enhanced growing neural gas algorithm for real-time adaptive neural spike clustering.

    abstract:OBJECTIVE:Real-time closed-loop neural feedback control requires the analysis of action potential traces within several milliseconds after they have been recorded from the brain. The current generation of spike clustering algorithms were mostly designed for off-line use and also require a significant amount of computat...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab208c

    authors: Mohammadi Z,Kincaid JM,Pun SH,Klug A,Liu C,Lei TC

    更新日期:2019-07-30 00:00:00

  • Electrode modifications to lower electrode impedance and improve neural signal recording sensitivity.

    abstract:OBJECTIVE:Although electrode size should be miniaturized to provide higher selectivity for neural signal recording and to avoid tissue damage, small sized electrodes induce high impedance, which decreases recording quality. In this work, the electrode surface was modified to increase the effective surface area to lower...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/5/056018

    authors: Chung T,Wang JQ,Wang J,Cao B,Li Y,Pang SW

    更新日期:2015-10-01 00:00:00

  • Toward closed-loop optimization of deep brain stimulation for Parkinson's disease: concepts and lessons from a computational model.

    abstract::Deep brain stimulation (DBS) of the subthalamic nucleus with periodic, high-frequency pulse trains is an increasingly standard therapy for advanced Parkinson's disease. Here, we propose that a closed-loop global optimization algorithm may identify novel DBS waveforms that could be more effective than their high-freque...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/4/2/L03

    authors: Feng XJ,Greenwald B,Rabitz H,Shea-Brown E,Kosut R

    更新日期:2007-06-01 00:00:00

  • Brain-computer interfacing under distraction: an evaluation study.

    abstract:OBJECTIVE:While motor-imagery based brain-computer interfaces (BCIs) have been studied over many years by now, most of these studies have taken place in controlled lab settings. Bringing BCI technology into everyday life is still one of the main challenges in this field of research. APPROACH:This paper systematically ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/5/056012

    authors: Brandl S,Frølich L,Höhne J,Müller KR,Samek W

    更新日期:2016-10-01 00:00:00

  • Ten-dimensional anthropomorphic arm control in a human brain-machine interface: difficulties, solutions, and limitations.

    abstract:OBJECTIVE:In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with tetraplegia using a brain-machine interface (BMI). The current study, in the same subject, immediately followed the previous work...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/1/016011

    authors: Wodlinger B,Downey JE,Tyler-Kabara EC,Schwartz AB,Boninger ML,Collinger JL

    更新日期:2015-02-01 00:00:00

  • Creation of virtual channels in the retina using synchronous and asynchronous stimulation - a modelling study.

    abstract:OBJECTIVE:Implantable retinal prostheses aim to provide artificial vision to those suffering from retinal degenerative diseases by electrically stimulating the remaining retinal neurons using a multi-electrode array. The spatial resolution of these devices can be improved by creation of so-called virtual channels (VCs)...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abc3a9

    authors: Song X,Guo T,Shivdasani MN,Dokos S,Lovell NH,Li X,Qiu S,Li T,Zheng S,Li L

    更新日期:2020-10-21 00:00:00

  • Influence of nerve cuff channel count and implantation site on the separability of afferent ENG.

    abstract:OBJECTIVE:Recording of neural signals from intact peripheral nerves in patients with spinal cord injury or stroke survivors offers the possibility for the development of closed-loop sensorimotor prostheses. Nerve cuffs have been found to provide stable recordings from peripheral nerves for prolonged periods of time. Ho...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aabca0

    authors: Silveira C,Brunton E,Spendiff S,Nazarpour K

    更新日期:2018-08-01 00:00:00