Hardware architecture for real-time EEG-based functional brain connectivity parameter extraction.

Abstract:

:In this work, we proposed a novel architecture for real-time quantitative characterization of functional brain connectivity networks derived from Electroencephalogram (EEG). It consists of two main parts - calculation of Phase Lag Index (PLI) to form the functional connectivity networks and the extraction of a set of graph-theoretic parameters to quantitatively characterize these networks. The architecture was developed for a 19-channel EEG system. The system can calculate all the functional connectivity parameters in a total time of 131µs, utilizes 71% logic resources, and shows 51.84 mW dynamic power consumption at 22.16 MHz operation frequency when implemented in a Stratix IV EP4SGX230K FPGA. Our analysis also showed that the system occupies an area equivalent to approximately 937K 2-input NAND gates, with an estimated power consumption of 39.3 mW at 0.9 V supply using a 90 nm CMOS Application Specific Integrated Circuit (ASIC) technology.

journal_name

J Neural Eng

authors

Gutierrez Nuno RA,Chung CHR,Maharatna K

doi

10.1088/1741-2552/abd462

subject

Has Abstract

pub_date

2020-12-16 00:00:00

eissn

1741-2560

issn

1741-2552

pub_type

杂志文章
  • An intra-operative feature-based classification of microelectrode recordings to support the subthalamic nucleus functional identification during deep brain stimulation surgery.

    abstract:OBJECTIVE:The Subthalamic Nucleus (STN) is the most selected target for the placement of the Deep Brain Stimulation (DBS) electrode to treat Parkinson's disease. Its identification is a delicate and challenging task which is based on the interpretation of the STN functional activity acquired through microelectrode reco...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abcb15

    authors: Coelli S,Levi V,Del Vecchio Del Vecchio J,Mailland E,Rinaldo S,Eleopra R,Bianchi AM

    更新日期:2020-11-17 00:00:00

  • Speech stream segregation to control an ERP-based auditory BCI.

    abstract:OBJECTIVE:The use of natural sounds in auditory Brain-Computer Interfaces (BCI) has been shown to improve classification results and usability. Some auditory BCIs are based on stream segregation, in which the subjects must attend one audio stream and ignore the other(s); these streams include some kind of stimuli to be...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abdd44

    authors: Velasco-Álvarez F,Fernández-Rodríguez Á,Medina-Juliá MT,Ron-Angevin R

    更新日期:2021-01-19 00:00:00

  • Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate.

    abstract:OBJECTIVE:Analysis of intra- and perioperatively recorded cortical and basal ganglia local field potentials in human movement disorders has provided great insight into the pathophysiology of diseases such as Parkinson's, dystonia, and essential tremor. However, in order to better understand the network abnormalities an...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/11/1/016009

    authors: Ryapolova-Webb E,Afshar P,Stanslaski S,Denison T,de Hemptinne C,Bankiewicz K,Starr PA

    更新日期:2014-02-01 00:00:00

  • Early seizure detection for closed loop direct neurostimulation devices in epilepsy.

    abstract::Current treatment concepts for epilepsy are based on continuous drug delivery or electrical stimulation to prevent the occurrence of seizures, exposing the brain and body to a mostly unneeded risk of adverse effects. To address the infrequent occurrence and short duration of epileptic seizures, intelligent implantable...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2552/ab094a

    authors: Dümpelmann M

    更新日期:2019-08-01 00:00:00

  • Estimates of distributed coding of visual objects by single neurons in the human brain depend on which spike sorting technique is used.

    abstract:OBJECTIVE:To determine whether the estimated fraction and degree of distribution of visual responsive neurons in human intracranial microwire recordings depends upon the spike sorting method used. APPROACH:A large dataset of human intracranial microwire recordings from four brain areas was sorted into single unit acti...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab6cb8

    authors: Steinmetz PN

    更新日期:2020-04-09 00:00:00

  • Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation.

    abstract:OBJECTIVE:Given current clinical interest in vagus nerve stimulation (VNS), there are surprisingly few studies characterizing the anatomy of the vagus nerve in large animal models as it pertains to on-and off-target engagement of local fibers. We sought to address this gap by evaluating vagal anatomy in the pig, whose ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab7ad4

    authors: Settell ML,Pelot NA,Knudsen BE,Dingle AM,McConico AL,Nicolai EN,Trevathan JK,Ezzell JA,Ross EK,Gustafson KJ,Shoffstall AJ,Williams JC,Zeng W,Poore SO,Populin LC,Suminski AJ,Grill WM,Ludwig KA

    更新日期:2020-04-09 00:00:00

  • Assessment of gliosis around moveable implants in the brain.

    abstract::Repositioning microelectrodes post-implantation is emerging as a promising approach to achieve long-term reliability in single neuronal recordings. The main goal of this study was to (a) assess glial reaction in response to movement of microelectrodes in the brain post-implantation and (b) determine an optimal window ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/4/046004

    authors: Stice P,Muthuswamy J

    更新日期:2009-08-01 00:00:00

  • In vivo feasibility of epiretinal stimulation using ultrananocrystalline diamond electrodes.

    abstract:OBJECTIVE:Due to their increased proximity to retinal ganglion cells (RGCs), epiretinal visual prostheses present the opportunity for eliciting phosphenes with low thresholds through direct RGC activation. This study characterised the in vivo performance of a novel prototype monolithic epiretinal prosthesis, containing...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aba560

    authors: Shivdasani MN,Evans M,Burns O,Yeoh J,Allen PJ,Nayagam DAX,Villalobos J,Abbott CJ,Luu CD,Opie NL,Sabu A,Saunders AL,McPhedran M,Cardamone L,McGowan C,Maxim V,Williams RA,Fox KE,Cicione R,Garrett DJ,Ahnood A,Ganes

    更新日期:2020-08-05 00:00:00

  • A high-density carbon fiber neural recording array technology.

    abstract:OBJECTIVE:Microwire and Utah-style neural recording arrays are the predominant devices used for cortical neural recording, but the implanted electrodes cause a significant adverse biological response and suffer from well-studied performance degradation. Recent work has demonstrated that carbon fiber electrodes do not e...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aae8d9

    authors: Massey TL,Santacruz SR,Hou JF,Pister KSJ,Carmena JM,Maharbiz MM

    更新日期:2019-02-01 00:00:00

  • Data augmentation for self-paced motor imagery classification with C-LSTM.

    abstract:OBJECTIVE:Brain-computer interfaces (BCI) are becoming important tools for assistive technology, particularly through the use of motor imagery (MI) for aiding task completion. However, most existing methods of MI classification have been applied in a trial-wise fashion, with window sizes of approximately 2 s or more. A...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab57c0

    authors: Freer D,Yang GZ

    更新日期:2020-01-31 00:00:00

  • On the risk of extracting relevant information from random data.

    abstract::This comment constitutes a re-assessment of a recent study in which near-infrared spectroscopy (NIRS) was used to decode decision making. In the original study, the process of feature selection was carried out on all of the data, and those features which displayed the greater classification accuracy were selected, but...

    journal_title:Journal of neural engineering

    pub_type: 评论,杂志文章

    doi:10.1088/1741-2560/6/5/058001

    authors: Dominguez LG

    更新日期:2009-10-01 00:00:00

  • Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks.

    abstract:OBJECTIVE:Functions ascribed to the hippocampal sub-regions for encoding episodic memories include the separation of activity patterns propagated from the entorhinal cortex (EC) into the dentate gyrus (DG) and pattern completion in CA3 region. Since a direct assessment of these functions is lacking at the level of spec...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aabc20

    authors: Poli D,Wheeler BC,DeMarse TB,Brewer GJ

    更新日期:2018-08-01 00:00:00

  • Decoding spoken English from intracortical electrode arrays in dorsal precentral gyrus.

    abstract:OBJECTIVE:To evaluate the potential of intracortical electrode array signals for brain-computer interfaces (BCIs) to restore lost speech, we measured the performance of decoders trained to discriminate a comprehensive basis set of 39 English phonemes and to synthesize speech sounds via a neural pattern matching method....

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abbfef

    authors: Wilson GH,Stavisky SD,Willett FR,Avansino DT,Kelemen JN,Hochberg LR,Henderson JM,Druckmann S,Shenoy KV

    更新日期:2020-11-25 00:00:00

  • Myoelectric control with abstract decoders.

    abstract:OBJECTIVE:The objective of this study was to compare the use of muscles appropriate for partial-hand prostheses with those typically used for complete hand devices and to determine whether differences in their underlying neural substrates translate to different levels of myoelectric control. APPROACH:We developed a no...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aacbfe

    authors: Dyson M,Barnes J,Nazarpour K

    更新日期:2018-10-01 00:00:00

  • Performance predictors of brain-computer interfaces in patients with amyotrophic lateral sclerosis.

    abstract:OBJECTIVE:Patients with amyotrophic lateral sclerosis (ALS) may benefit from brain-computer interfaces (BCI), but the utility of such devices likely will have to account for the functional, cognitive, and behavioral heterogeneity of this neurodegenerative disorder. APPROACH:In this study, a heterogeneous group of pati...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/2/026002

    authors: Geronimo A,Simmons Z,Schiff SJ

    更新日期:2016-04-01 00:00:00

  • Brain-computer interfacing under distraction: an evaluation study.

    abstract:OBJECTIVE:While motor-imagery based brain-computer interfaces (BCIs) have been studied over many years by now, most of these studies have taken place in controlled lab settings. Bringing BCI technology into everyday life is still one of the main challenges in this field of research. APPROACH:This paper systematically ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/5/056012

    authors: Brandl S,Frølich L,Höhne J,Müller KR,Samek W

    更新日期:2016-10-01 00:00:00

  • Algorithms and architectures for low power spike detection and alignment.

    abstract::We introduce algorithms and architectures for automatic spike detection and alignment that are designed for low power. Some of the algorithms are based on principal component analysis (PCA). Others employ a novel integral transform analysis and achieve 99% of the precision of a PCA detector, while requiring only 0.05%...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/3/1/004

    authors: Zviagintsev A,Perelman Y,Ginosar R

    更新日期:2006-03-01 00:00:00

  • Accuracy assessment of CKC high-density surface EMG decomposition in biceps femoris muscle.

    abstract::The aim of this study was to assess the accuracy of the convolution kernel compensation (CKC) method in decomposing high-density surface EMG (HDsEMG) signals from the pennate biceps femoris long-head muscle. Although the CKC method has already been thoroughly assessed in parallel-fibered muscles, there are several fac...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/8/6/066002

    authors: Marateb HR,McGill KC,Holobar A,Lateva ZC,Mansourian M,Merletti R

    更新日期:2011-12-01 00:00:00

  • Constant pressure fluid infusion into rat neocortex from implantable microfluidic devices.

    abstract::Implantable electrode arrays capable of recording and stimulating neural activity with high spatial and temporal resolution will provide a foundation for future brain computer interface technology. Currently, their clinical impact has been curtailed by a general lack of functional stability, which can be attributed to...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/5/4/003

    authors: Retterer ST,Smith KL,Bjornsson CS,Turner JN,Isaacson MS,Shain W

    更新日期:2008-12-01 00:00:00

  • Single input optimal control for globally coupled neuron networks.

    abstract::We consider the problem of desynchronizing a network of synchronized, globally (all-to-all) coupled neurons using an input to a single neuron. This is done by applying the discrete time dynamic programming method to reduced phase models for neural populations. This technique numerically minimizes a certain cost functi...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/8/6/065008

    authors: Nabi A,Moehlis J

    更新日期:2011-12-01 00:00:00

  • Applying dynamic data collection to improve dry electrode system performance for a P300-based brain-computer interface.

    abstract:OBJECTIVE:Dry electrodes have an advantage over gel-based 'wet' electrodes by providing quicker set-up time for electroencephalography recording; however, the potentially poorer contact can result in noisier recordings. We examine the impact that this may have on brain-computer interface communication and potential app...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/6/066018

    authors: Clements JM,Sellers EW,Ryan DB,Caves K,Collins LM,Throckmorton CS

    更新日期:2016-12-01 00:00:00

  • Stability and selectivity of a chronic, multi-contact cuff electrode for sensory stimulation in human amputees.

    abstract:OBJECTIVE:Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. APPROACH:Multi-contact cuff electrode...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/2/026002

    authors: Tan DW,Schiefer MA,Keith MW,Anderson JR,Tyler DJ

    更新日期:2015-04-01 00:00:00

  • Transparent, low-autofluorescence microECoG device for simultaneous Ca2+ imaging and cortical electrophysiology in vivo.

    abstract:OBJECTIVE:Multimodal neuroimaging approaches are beneficial to discover brain functionalities at high spatial and temporal resolution. In our work, a novel material composition of a microECoG device relying on Parylene HT and indium-tin-oxide (ITO) is presented, which facilitates two-photon imaging of Ca2+ signals and ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab603f

    authors: Zátonyi A,Madarász M,Szabó Á,Lőrincz T,Hodován R,Rózsa B,Fekete Z

    更新日期:2020-02-18 00:00:00

  • Bipolar electrode selection for a motor imagery based brain-computer interface.

    abstract::A motor imagery based brain-computer interface (BCI) provides a non-muscular communication channel that enables people with paralysis to control external devices using their motor imagination. Reducing the number of electrodes is critical to improving the portability and practicability of the BCI system. A novel metho...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/5/3/007

    authors: Lou B,Hong B,Gao X,Gao S

    更新日期:2008-09-01 00:00:00

  • The impact of calcium current reversal on neurotransmitter release in the electrically stimulated retina.

    abstract:OBJECTIVE:In spite of intense theoretical and experimental investigations on electrical nerve stimulation, the influence of reversed ion currents on network activity during extracellular stimulation has not been investigated so far. APPROACH:Here, the impact of calcium current reversal on neurotransmitter release duri...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/4/046013

    authors: Werginz P,Rattay F

    更新日期:2016-08-01 00:00:00

  • Suppression of scarring in peripheral nerve implants by drug elution.

    abstract:OBJECTIVE:Medical implants made of non-biological materials provoke a chronic inflammatory response, resulting in the deposition of a collagenous scar tissue (ST) layer on their surface, that gradually thickens over time. This is a critical problem for neural interfaces. Scar build-up on electrodes results in a progres...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/2/026006

    authors: FitzGerald JJ

    更新日期:2016-04-01 00:00:00

  • Brain-computer interface based on intermodulation frequency.

    abstract:OBJECTIVE:Most recent steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) systems have used a single frequency for each target, so that a large number of targets require a large number of stimulus frequencies and therefore a wider frequency band. However, human beings show good SSVEP respo...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/6/066009

    authors: Chen X,Chen Z,Gao S,Gao X

    更新日期:2013-12-01 00:00:00

  • Automatic spike sorting for extracellular electrophysiological recording using unsupervised single linkage clustering based on grey relational analysis.

    abstract::Automatic spike sorting is a prerequisite for neuroscience research on multichannel extracellular recordings of neuronal activity. A novel spike sorting framework, combining efficient feature extraction and an unsupervised clustering method, is described here. Wavelet transform (WT) is adopted to extract features from...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/8/3/036003

    authors: Lai HY,Chen YY,Lin SH,Lo YC,Tsang S,Chen SY,Zhao WT,Chao WH,Chang YC,Wu R,Shih YY,Tsai ST,Jaw FS

    更新日期:2011-06-01 00:00:00

  • Improving an open-source commercial system to reliably perform activity-dependent stimulation.

    abstract:OBJECTIVE:Activity-dependent stimulation (ADS) is designed to strengthen the connections between neuronal circuits and therefore may be a promising tool for promoting neurophysiological reorganization following a brain injury. To successfully perform this technique, two criteria must be met: (1) spikes in the extracell...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab3319

    authors: Murphy M,Buccelli S,Bornat Y,Bundy D,Nudo R,Guggenmos D,Chiappalone M

    更新日期:2019-10-29 00:00:00

  • 3D Parylene sheath neural probe for chronic recordings.

    abstract:OBJECTIVE:Reliable chronic recordings from implanted neural probes remain a significant challenge; current silicon-based and microwire technologies experience a wide range of biotic and abiotic failure modes contributing to loss of signal quality. APPROACH:A multi-prong alternative strategy with potential to overcome ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/4/045002

    authors: Kim BJ,Kuo JT,Hara SA,Lee CD,Yu L,Gutierrez CA,Hoang TQ,Pikov V,Meng E

    更新日期:2013-08-01 00:00:00