Abstract:
OBJECTIVE:Reliable chronic recordings from implanted neural probes remain a significant challenge; current silicon-based and microwire technologies experience a wide range of biotic and abiotic failure modes contributing to loss of signal quality. APPROACH:A multi-prong alternative strategy with potential to overcome these hurdles is introduced that combines a novel three dimensional (3D), polymer-based probe structure with coatings. Specifically, the Parylene C sheath-based neural probe is coated with neurotrophic and anti-inflammatory factors loaded onto a Matrigel carrier to encourage the ingrowth of neuronal processes for improved recording quality, reduce the immune response, and promote improved probe integration into brain tissue for reliable, long-term implementation compared to its rigid counterparts. MAIN RESULTS:The 3D sheath structure of the probe was formed by thermal molding of a surface micromachined Parylene C microchannel, with electrode sites lining the interior and exterior regions of the lumen. Electrochemical characterization of the probes via cyclic voltammetry and electrochemical impedance spectroscopy was performed and indicated suitable electrode properties for neural recordings (1 kHz electrical impedance of ∼200 kΩ in vitro). A novel introducer tool for the insertion of the compliant polymer probe into neural tissue was developed and validated both in vitro using agarose gel and in vivo in the rat cerebral cortex. In vivo electrical functionality of the Parylene C-based 3D probes and their suitability for recording the neuronal activity over a 28-day period was demonstrated by maintaining the 1 kHz electrical impedance within a functional range (<400 kΩ) and achieving a reasonably high signal-to-noise ratio for detection of resolvable multi-unit neuronal activity on most recording sites in the probe. Immunohistochemical analysis of the implant site indicated strong correlations between the quality of recorded activity and the neuronal/astrocytic density around the probe. SIGNIFICANCE:The provided electrophysiological and immunohistochemical data provide strong support to the viability of the developed probe technology. Furthermore, the obtained data provide insights into further optimization of the probe design, including tip geometry, use of neurotrophic and anti-inflammatory drugs in the Matrigel coating, and placement of the recording sites.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Kim BJ,Kuo JT,Hara SA,Lee CD,Yu L,Gutierrez CA,Hoang TQ,Pikov V,Meng Edoi
10.1088/1741-2560/10/4/045002subject
Has Abstractpub_date
2013-08-01 00:00:00pages
045002issue
4eissn
1741-2560issn
1741-2552journal_volume
10pub_type
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
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更新日期:2014-06-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of neural engineering
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doi:10.1088/1741-2552/aba6dd
更新日期:2020-08-11 00:00:00
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更新日期:2020-06-12 00:00:00
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更新日期:2015-08-01 00:00:00
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更新日期:2019-07-30 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00