Abstract:
OBJECTIVE:Electrical status epilepticus during sleep (ESES), as electroencephalographic disturbances, is characterized by strong activation of epileptiform activity in the electroencephalogram during sleep. Quantitative descriptors of such epileptiform activity can support the diagnose and the prognosis of children with ESES. To quantify the epileptiform activity of ESES, a knowledge-based approach to mimic the clinical decision-making process is proposed. APPROACH:Firstly, a morphological operations-based scheme is designed to quickly locate the positive peaks/negative pits and roughly estimate the onset/offset of spike and slow-wave abnormalities. Then, to provide the accurate duration of ESES patterns, a set of rules for further adjusting these onsets/offsets are proposed by merging medical knowledge with a generalized threshold obtained from statistics. As such, the quantification is accomplished by evaluating the obtained spike and slow-wave abnormalities and their various durations. MAIN RESULTS:The effectiveness and feasibility of the proposed method were evaluated on a clinical dataset that collected at Children's Hospital of Fudan University, Shanghai, China. We demonstrate that the proposed method can recognize different types of spike and slow-wave abnormalities. The sensitivity, precision, and false positive rate achieved 91.96%, 97.09%, and 1.88 min-1, respectively. The estimation error for the spike-wave index was 2.32%. Comparison results showed that our method outperforms the state-of-the-art. SIGNIFICANCE:The quantification of spike and slow-waves provides information about ESES activity. The detection of variations types of spike and slow-waves improves the performance in the quantification of ESES. Experimental results suggest that the proposed method has great potential in automatic ESES quantification and can help improve the diagnosis and researches of epileptic encephalopathy with ESES.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Zhao X,Wang X,Chen C,Fan J,Yu X,Wang Z,Akbarzadeh S,Li Q,Zhou S,Chen Wdoi
10.1088/1741-2552/aba6ddsubject
Has Abstractpub_date
2020-08-11 00:00:00pages
046032issue
4eissn
1741-2560issn
1741-2552journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:A primary control signal in brain-computer interfaces (BCIs) have been cortical signals related to movement. However, in cases where natural motor function remains, BCI control signals may interfere with other possibly simultaneous activity for useful ongoing movement. We sought to determine if the brain coul...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aadf3d
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. In cortic...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aafbfb
更新日期:2019-04-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common cause of dementia. Over the last few years, a considerable effort has been devoted to exploring new biomarkers. Nevertheless, a better understanding of brain dynamics is still required to optimize therapeutic strategies. In this regard, the characterization of mild cognitive...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/3/036007
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods. The optimal threshold for extracting information from auditory cortex has yet to be ide...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab7c19
更新日期:2020-03-03 00:00:00
abstract:OBJECTIVE:By means of subjective psychophysical methods, quality of transmitted speech has been decomposed into three perceptual dimensions named 'discontinuity' (F), 'noisiness' (N) and 'coloration' (C). Previous studies using electroencephalography (EEG) already reported effects of perceived intensity of single quali...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf122
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:We aim to increase the number of neural spikes that can be detected in a single channel extracellular neural recording. APPROACH:We propose a pre-emphasis method facilitating stochastic resonance (SR), where we introduce the band-pass-filtered noisy extracellular recording to an overdamped Brownian particle ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abae8a
更新日期:2020-09-18 00:00:00
abstract:OBJECTIVE:Ultrasounds (US) use in neural engineering is so far mainly limited to ablation through high intensity focused ultrasound, but interesting preliminary results show that low intensity low frequency ultrasound could be used instead to modulate neural activity. However, the extent of this modulatory ability of U...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abae8b
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVE:To evaluate the potential of intracortical electrode array signals for brain-computer interfaces (BCIs) to restore lost speech, we measured the performance of decoders trained to discriminate a comprehensive basis set of 39 English phonemes and to synthesize speech sounds via a neural pattern matching method....
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abbfef
更新日期:2020-11-25 00:00:00
abstract::This review paper shows that tungsten should not generally be used as a chronically implanted material. The metal has a long implant history, from neuroscience, vascular medicine, radiography, orthopaedics, prosthodontics, and various other fields, primarily as a result of its high density, radiopacity, tensile streng...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2552/aaa502
更新日期:2018-04-01 00:00:00
abstract::A motor imagery based brain-computer interface (BCI) provides a non-muscular communication channel that enables people with paralysis to control external devices using their motor imagination. Reducing the number of electrodes is critical to improving the portability and practicability of the BCI system. A novel metho...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/3/007
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Multimodal neuroimaging approaches are beneficial to discover brain functionalities at high spatial and temporal resolution. In our work, a novel material composition of a microECoG device relying on Parylene HT and indium-tin-oxide (ITO) is presented, which facilitates two-photon imaging of Ca2+ signals and ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab603f
更新日期:2020-02-18 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) are confronted with two fundamental challenges: (a) the uncertainty associated with decoding noisy brain signals, and (b) the need for co-adaptation between the brain and the interface so as to cooperatively achieve a common goal in a task. We seek to mitigate these challenges...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/6/066008
更新日期:2013-12-01 00:00:00
abstract::To study cell-field dynamics, physiologists simultaneously record local field potentials and the activity of individual cells from animals performing cognitive tasks, during various brain states or under pathological conditions. However, apart from spike shape and spike timing analyses, few studies have focused on elu...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/4/046024
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:The aim of this paper was to characterize brain non-stationarity during an auditory oddball task in schizophrenia (SCH). The level of non-stationarity was measured in the baseline and response windows of relevant tones in SCH patients and healthy controls. APPROACH:Event-related potentials were recorded from...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6e05
更新日期:2017-08-01 00:00:00
abstract::In this paper, we investigate the influence of hypercapnia on the dynamics of the phrenic neurogram in the piglet in two different age groups: 3-7 days (n = 11) and 10-16 days (n = 9). The phrenic neurogram was recorded from 17 piglets (3-16 days old) during control (40% O(2) with 3-5% end-tidal CO(2)), mild hypercapn...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/2/2/004
更新日期:2005-06-01 00:00:00
abstract::Functional mapping of eloquent cortex is a common and necessary component of neurosurgical operative planning. Current electrical stimulation-based techniques are inefficient, can evoke seizures and are prone to false-negative results. Here, we present a novel cortical mapping system that extracts event-related neural...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/4/046018
更新日期:2012-08-01 00:00:00
abstract::Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/3/003
更新日期:2007-09-01 00:00:00
abstract::Repositioning microelectrodes post-implantation is emerging as a promising approach to achieve long-term reliability in single neuronal recordings. The main goal of this study was to (a) assess glial reaction in response to movement of microelectrodes in the brain post-implantation and (b) determine an optimal window ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/4/046004
更新日期:2009-08-01 00:00:00
abstract::In a recent paper by Bradberry, Gentili and Contreras-Vidal published in Journal of Neural Engineering (2011, 8 036010), an interesting method for the control of a two-dimensional mouse cursor was proposed, which apparently attained excellent control and good speed with relatively simple techniques. We believe some of...
journal_title:Journal of neural engineering
pub_type: 评论,杂志文章
doi:10.1088/1741-2560/8/5/058001
更新日期:2011-10-01 00:00:00
abstract::This paper describes the technological developments underlying the realization of a reliable and reproducible microchip-based stimulator with a large number of stimulus electrodes. A microchip-based stimulator with over 500 electrodes for suprachoroidal transretinal stimulation (STS) is proposed in this paper, and an ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/1/S10
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Electroencephalography (EEG) offers a unique opportunity to study human neural activity non-invasively with millisecond resolution using minimal equipment in or outside of a lab setting. EEG can be combined with a number of techniques for closed-loop experiments, where external devices are driven by specific ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa651f
更新日期:2017-06-01 00:00:00
abstract::We conducted an experiment to determine whether the rhythm with which imagined syllables are produced may be decoded from EEG recordings. High density EEG data were recorded for seven subjects while they produced in imagination one of two syllables in one of three different rhythms. We used a modified second-order bli...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/4/046006
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:Spinal cord stimulation (SCS) is a common neurostimulation therapy to treat chronic pain. Computational models represent a valuable tool to study the potential mechanisms of action of SCS and to optimize the design and implementation of SCS technologies. However, it is imperative that these computational mode...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab8fc4
更新日期:2020-06-12 00:00:00
abstract:OBJECTIVE:In spite of intense theoretical and experimental investigations on electrical nerve stimulation, the influence of reversed ion currents on network activity during extracellular stimulation has not been investigated so far. APPROACH:Here, the impact of calcium current reversal on neurotransmitter release duri...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/13/4/046013
更新日期:2016-08-01 00:00:00
abstract::Neural activity can be modulated by applying a polarizing low-frequency (<100 Hz) electric field (PLEF). Unlike conventional pulsed stimulation, PLEF stimulation has a graded, modulatory effect on neuronal excitability, and permits the simultaneous recording of neuronal activity during stimulation suitable for continu...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/4/046009
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:We have recently developed a prototype of a novel human-computer interface for assistive communication based on voluntary shifts of attention (gaze) from a far target to a near target associated with a decrease of pupil size (Pupillary Accommodative Response, PAR), an automatic vegetative response that can be...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab8e8f
更新日期:2020-04-29 00:00:00
abstract:OBJECTIVE:The goal of this study is to characterize the phenomenon of evoked tactile sensation (ETS) on the stump skin of forearm amputees using transcutaneous electrical nerve stimulation (TENS). APPROACH:We identified the projected finger map (PFM) of ETS on the stump skin in 11 forearm amputees, and compared percep...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/6/066002
更新日期:2015-12-01 00:00:00
abstract::Human trials of prototype visual prostheses have successfully elicited visual percepts (phosphenes) in the visual field of implant recipients blinded through retinitis pigmentosa and age-related macular degeneration. Researchers are progressing rapidly towards a device that utilizes individual phosphenes as the elemen...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/6/3/035009
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with tetraplegia using a brain-machine interface (BMI). The current study, in the same subject, immediately followed the previous work...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/1/016011
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCI) are becoming important tools for assistive technology, particularly through the use of motor imagery (MI) for aiding task completion. However, most existing methods of MI classification have been applied in a trial-wise fashion, with window sizes of approximately 2 s or more. A...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab57c0
更新日期:2020-01-31 00:00:00