Anatomical and technical factors affecting the neural response to epidural spinal cord stimulation.

Abstract:

OBJECTIVE:Spinal cord stimulation (SCS) is a common neurostimulation therapy to treat chronic pain. Computational models represent a valuable tool to study the potential mechanisms of action of SCS and to optimize the design and implementation of SCS technologies. However, it is imperative that these computational models include the appropriate level of detail to accurately predict the neural response to SCS and to correlate model predictions with clinical outcomes. Therefore, the goal of this study was to investigate several anatomic and technical factors that may affect model-based predictions of neural activation during thoracic SCS. APPROACH:We developed computational models that consisted of detailed finite element models of the lower thoracic spinal cord, surrounding tissues, and implanted SCS electrode arrays. We positioned multicompartment models of sensory axons within the spinal cord to calculate the activation threshold for each sensory axon. We then investigated how activation thresholds changed as a function of several anatomical variables (e.g. spine geometry, dorsal rootlet anatomy), stimulation type (i.e. voltage-controlled vs. current-controlled), electrode impedance, lead position, lead type, and electrical properties of surrounding tissues (e.g. dura conductivity, frequency-dependent conductivity). MAIN RESULTS:Several anatomic and modeling factors produced significant percent differences or errors in activation thresholds. Rostrocaudal positioning of the cathode with respect to the vertebrae had a large effect (up to 32%) on activation thresholds. Variability in electrode impedance produced significant changes in activation thresholds for voltage-controlled stimulation (38% to 51%), but had little effect on activation thresholds for current-controlled stimulation (less than 13%). Changing the dura conductivity also produced significant differences in activation thresholds. SIGNIFICANCE:This study demonstrates several anatomic and technical factors that can affect the neural response to SCS. These factors should be considered in clinical implementation and in future computational modeling studies of thoracic SCS.

journal_name

J Neural Eng

authors

Zander HJ,Graham RD,Anaya CJ,Lempka SF

doi

10.1088/1741-2552/ab8fc4

subject

Has Abstract

pub_date

2020-06-12 00:00:00

pages

036019

issue

3

eissn

1741-2560

issn

1741-2552

journal_volume

17

pub_type

杂志文章
  • Remapping cortical modulation for electrocorticographic brain-computer interfaces: a somatotopy-based approach in individuals with upper-limb paralysis.

    abstract:OBJECTIVE:Brain-computer interface (BCI) technology aims to provide individuals with paralysis a means to restore function. Electrocorticography (ECoG) uses disc electrodes placed on either the surface of the dura or the cortex to record field potential activity. ECoG has been proposed as a viable neural recording moda...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa9bfb

    authors: Degenhart AD,Hiremath SV,Yang Y,Foldes S,Collinger JL,Boninger M,Tyler-Kabara EC,Wang W

    更新日期:2018-04-01 00:00:00

  • Towards a symbiotic brain-computer interface: exploring the application-decoder interaction.

    abstract:OBJECTIVE:State of the art brain-computer interface (BCI) research focuses on improving individual components such as the application or the decoder that converts the user's brain activity to control signals. In this study, we investigate the interaction between these components in the P300 speller, a BCI for communica...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/6/066027

    authors: Verhoeven T,Buteneers P,Wiersema JR,Dambre J,Kindermans PJ

    更新日期:2015-12-01 00:00:00

  • Conditional firing probabilities in cultured neuronal networks: a stable underlying structure in widely varying spontaneous activity patterns.

    abstract::To properly observe induced connectivity changes after training sessions, one needs a network model that describes individual relationships in sufficient detail to enable observation of induced changes and yet reveals some kind of stability in these relationships. We analyzed spontaneous firing activity in dissociated...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/4/2/006

    authors: le Feber J,Rutten WL,Stegenga J,Wolters PS,Ramakers GJ,van Pelt J

    更新日期:2007-06-01 00:00:00

  • The analytic common spatial patterns method for EEG-based BCI data.

    abstract::One of the most important stages in a brain-computer interface (BCI) system is that of extracting features that can reliably discriminate data recorded during different user states. A popular technique used for feature extraction in BCIs is the common spatial patterns (CSP) method, which provides a set of spatial filt...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/9/4/045009

    authors: Falzon O,Camilleri KP,Muscat J

    更新日期:2012-08-01 00:00:00

  • Comparison of spike sorting and thresholding of voltage waveforms for intracortical brain-machine interface performance.

    abstract:OBJECTIVE:For intracortical brain-machine interfaces (BMIs), action potential voltage waveforms are often sorted to separate out individual neurons. If these neurons contain independent tuning information, this process could increase BMI performance. However, the sorting of action potentials ('spikes') requires high sa...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/1/016009

    authors: Christie BP,Tat DM,Irwin ZT,Gilja V,Nuyujukian P,Foster JD,Ryu SI,Shenoy KV,Thompson DE,Chestek CA

    更新日期:2015-02-01 00:00:00

  • Towards a hemodynamic BCI using transcranial Doppler without user-specific training data.

    abstract:UNLABELLED:Transcranial Doppler (TCD) was recently introduced as a new brain-computer interface (BCI) modality for detecting task-induced hemispheric lateralization. To date, single-trial discrimination between a lateralized mental activity and a rest state has been demonstrated with long (45 s) activation time periods...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/1/016005

    authors: Aleem I,Chau T

    更新日期:2013-02-01 00:00:00

  • Assessing altered motor unit recruitment patterns in paretic muscles of stroke survivors using surface electromyography.

    abstract:OBJECTIVE:The advancement of surface electromyogram (sEMG) recording and signal processing techniques has allowed us to characterize the recruitment properties of a substantial population of motor units (MUs) non-invasively. Here we seek to determine whether MU recruitment properties are modified in paretic muscles of ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/6/066001

    authors: Hu X,Suresh AK,Rymer WZ,Suresh NL

    更新日期:2015-12-01 00:00:00

  • Effects of stimulation frequency and stimulation waveform on steady-state visual evoked potentials using a computer monitor.

    abstract:OBJECTIVE:A visual stimulator plays a vital part in brain-computer interfaces (BCIs) based on steady-state visual evoked potential (SSVEP). The properties of visual stimulation, such as frequency, color, and waveform, will influence SSVEP-based BCI performance to some extent. Recently, the computer monitor serves as a ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab2b7d

    authors: Chen X,Wang Y,Zhang S,Xu S,Gao X

    更新日期:2019-10-10 00:00:00

  • Human-inspired sound environment recognition system for assistive vehicles.

    abstract:OBJECTIVE:The human auditory system acquires environmental information under sound stimuli faster than visual or touch systems, which in turn, allows for faster human responses to such stimuli. It also complements senses such as sight, where direct line-of-view is necessary to identify objects, in the environment recog...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/1/016012

    authors: Vidal EG,Zarricueta EF,Cheein FA

    更新日期:2015-02-01 00:00:00

  • Altered electroencephalography functional connectivity in depression during the emotional face-word Stroop task.

    abstract:OBJECTIVE:Depression is a severe mental disorder. However, the neural mechanisms underlying affective interference (difficulties in directing attention away from negative distractors) in depression patients are still not well-understood. In particular, the connections between brain regions remain unclear. Using the emo...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aacdbb

    authors: Guo Z,Wu X,Liu J,Yao L,Hu B

    更新日期:2018-10-01 00:00:00

  • Multiresolution analysis over simple graphs for brain computer interfaces.

    abstract:OBJECTIVE:Multiresolution analysis (MRA) offers a useful framework for signal analysis in the temporal and spectral domains, although commonly employed MRA methods may not be the best approach for brain computer interface (BCI) applications. This study aims to develop a new MRA system for extracting tempo-spatial-spect...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/10/4/046014

    authors: Asensio-Cubero J,Gan JQ,Palaniappan R

    更新日期:2013-08-01 00:00:00

  • In vivo feasibility of epiretinal stimulation using ultrananocrystalline diamond electrodes.

    abstract:OBJECTIVE:Due to their increased proximity to retinal ganglion cells (RGCs), epiretinal visual prostheses present the opportunity for eliciting phosphenes with low thresholds through direct RGC activation. This study characterised the in vivo performance of a novel prototype monolithic epiretinal prosthesis, containing...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aba560

    authors: Shivdasani MN,Evans M,Burns O,Yeoh J,Allen PJ,Nayagam DAX,Villalobos J,Abbott CJ,Luu CD,Opie NL,Sabu A,Saunders AL,McPhedran M,Cardamone L,McGowan C,Maxim V,Williams RA,Fox KE,Cicione R,Garrett DJ,Ahnood A,Ganes

    更新日期:2020-08-05 00:00:00

  • Early seizure detection for closed loop direct neurostimulation devices in epilepsy.

    abstract::Current treatment concepts for epilepsy are based on continuous drug delivery or electrical stimulation to prevent the occurrence of seizures, exposing the brain and body to a mostly unneeded risk of adverse effects. To address the infrequent occurrence and short duration of epileptic seizures, intelligent implantable...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,评审

    doi:10.1088/1741-2552/ab094a

    authors: Dümpelmann M

    更新日期:2019-08-01 00:00:00

  • Evoked haptic sensations in the hand via non-invasive proximal nerve stimulation.

    abstract:OBJECTIVE:Haptic perception of a prosthetic limb or hand is a crucial, but often unmet, need which impacts the utility of the prostheses. In this study, we seek to evaluate the feasibility of a non-invasive transcutaneous nerve stimulation method in generating haptic feedback in a transradial amputee subject as well as...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aabd5d

    authors: Shin H,Watkins Z,Huang HH,Zhu Y,Hu X

    更新日期:2018-08-01 00:00:00

  • Constant pressure fluid infusion into rat neocortex from implantable microfluidic devices.

    abstract::Implantable electrode arrays capable of recording and stimulating neural activity with high spatial and temporal resolution will provide a foundation for future brain computer interface technology. Currently, their clinical impact has been curtailed by a general lack of functional stability, which can be attributed to...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/5/4/003

    authors: Retterer ST,Smith KL,Bjornsson CS,Turner JN,Isaacson MS,Shain W

    更新日期:2008-12-01 00:00:00

  • Neural correlates of speech quality dimensions analyzed using electroencephalography (EEG).

    abstract:OBJECTIVE:By means of subjective psychophysical methods, quality of transmitted speech has been decomposed into three perceptual dimensions named 'discontinuity' (F), 'noisiness' (N) and 'coloration' (C). Previous studies using electroencephalography (EEG) already reported effects of perceived intensity of single quali...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaf122

    authors: Uhrig S,Mittag G,Möller S,Voigt-Antons JN

    更新日期:2019-06-01 00:00:00

  • Functional consequences of model complexity in rhythmic systems: II. Systems performance of model and hybrid oscillators.

    abstract::Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/4/3/003

    authors: Sorensen ME,DeWeerth SP

    更新日期:2007-09-01 00:00:00

  • Optimizing the design of bipolar nerve cuff electrodes for improved recording of peripheral nerve activity.

    abstract:OBJECTIVE:Differential measurement of efferent and afferent peripheral nerve activity offers a promising means of improving the clinical utility of implantable neuroprostheses. The tripolar nerve cuff electrode has historically served as the gold standard for achieving high signal-to-noise ratios (SNRs) of the recordin...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aa6407

    authors: Sabetian P,Popovic MR,Yoo PB

    更新日期:2017-06-01 00:00:00

  • Inclusion of temporal priors for automated neonatal EEG classification.

    abstract::The aim of this paper is to use recent advances in the clinical understanding of the temporal evolution of seizure burden in neonates with hypoxic ischemic encephalopathy to improve the performance of automated detection algorithms. Probabilistic weights are designed from temporal locations of neonatal seizure events ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/9/4/046002

    authors: Temko A,Stevenson N,Marnane W,Boylan G,Lightbody G

    更新日期:2012-08-01 00:00:00

  • Achieving a hybrid brain-computer interface with tactile selective attention and motor imagery.

    abstract:OBJECTIVE:We propose a new hybrid brain-computer interface (BCI) system that integrates two different EEG tasks: tactile selective attention (TSA) using a vibro-tactile stimulator on the left/right finger and motor imagery (MI) of left/right hand movement. Event-related desynchronization (ERD) from the MI task and stea...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章,随机对照试验

    doi:10.1088/1741-2560/11/6/066004

    authors: Ahn S,Ahn M,Cho H,Chan Jun S

    更新日期:2014-12-01 00:00:00

  • Towards a ternary NIRS-BCI: single-trial classification of verbal fluency task, Stroop task and unconstrained rest.

    abstract:OBJECTIVE:The majority of near-infrared spectroscopy (NIRS) brain-computer interface (BCI) studies have investigated binary classification problems. Limited work has considered differentiation of more than two mental states, or multi-class differentiation of higher-level cognitive tasks using measurements outside of th...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/12/6/066008

    authors: C Schudlo L,Chau T

    更新日期:2015-12-01 00:00:00

  • Lower layers in the motor cortex are more effective targets for penetrating microelectrodes in cortical prostheses.

    abstract::Improving cortical prostheses requires the development of recording neural interfaces that are efficient in terms of providing maximal control information with minimal interface complexity. While the typical approaches have targeted neurons in the motor cortex with multiple penetrating shanks, an alternative approach ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/2/026004

    authors: Parikh H,Marzullo TC,Kipke DR

    更新日期:2009-04-01 00:00:00

  • Digital filters for low-latency quantification of brain rhythms in real time.

    abstract:OBJECTIVE:The rapidly developing paradigm of closed-loop neuroscience has extensively employed brain rhythms as the signal forming real-time neurofeedback, triggering brain stimulation, or governing stimulus selection. However, the efficacy of brain rhythm contingent paradigms suffers from significant delays related to...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab890f

    authors: Smetanin N,Belinskaya A,Lebedev M,Ossadtchi A

    更新日期:2020-08-04 00:00:00

  • Corrigendum: Tissue-engineered nerve grafts using a scaffold-independent and injectable drug delivery system: a novel design with translational advantages (2019 J. Neural Eng. 16 036030).

    abstract:OBJECTIVE:Currently commercially available nerve conduits have demonstrated suboptimal clinical efficacy in repairing peripheral nerve defects. Although tissue-engineered nerve grafts (TENGs) with sustained release of neurotrophic factors (NTFs) are experimentally proved to be more effective than these blank conduits, ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/abd1ec

    authors: Liu Y,Yu S,Gu X,Cao R,Cui S

    更新日期:2020-12-09 00:00:00

  • Machine learning validation of EEG+tACS artefact removal.

    abstract:OBJECTIVE:Electroencephalography (EEG) recorded during transcranial alternating current simulation (tACS) is highly desirable in order to investigate brain dynamics during stimulation, but is corrupted by large amplitude stimulation artefacts. Artefact removal algorithms have been presented previously, but with substan...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/ab58a3

    authors: Kohli S,Casson AJ

    更新日期:2020-01-24 00:00:00

  • Evaluation of probabilistic methods to predict muscle activity: implications for neuroprosthetics.

    abstract::Functional electrical stimulation (FES) involves artificial activation of muscles with surface or implanted electrodes to restore motor function in paralyzed individuals. Currently, FES-based prostheses produce only a limited range of movements due to the difficulty associated with identifying patterns of muscle activ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/6/5/055008

    authors: Johnson LA,Fuglevand AJ

    更新日期:2009-10-01 00:00:00

  • Autoencoders for learning template spectrograms in electrocorticographic signals.

    abstract:OBJECTIVE:Electrocorticography (ECoG) based studies generally analyze features from specific frequency bands selected by manual evaluation of spectral power. However, the definition of these features can vary across subjects, cortical areas, tasks and across time for a given subject. We propose an autoencoder based app...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aaf13f

    authors: Pailla T,Miller KJ,Gilja V

    更新日期:2019-02-01 00:00:00

  • Chronic recording of hand prosthesis control signals via a regenerative peripheral nerve interface in a rhesus macaque.

    abstract:OBJECTIVE:Loss of even part of the upper limb is a devastating injury. In order to fully restore natural function when lacking sufficient residual musculature, it is necessary to record directly from peripheral nerves. However, current approaches must make trade-offs between signal quality and longevity which limit the...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2560/13/4/046007

    authors: Irwin ZT,Schroeder KE,Vu PP,Tat DM,Bullard AJ,Woo SL,Sando IC,Urbanchek MG,Cederna PS,Chestek CA

    更新日期:2016-08-01 00:00:00

  • Multiband tangent space mapping and feature selection for classification of EEG during motor imagery.

    abstract:OBJECTIVE:When designing multiclass motor imagery-based brain-computer interface (MI-BCI), a so-called tangent space mapping (TSM) method utilizing the geometric structure of covariance matrices is an effective technique. This paper aims to introduce a method using TSM for finding accurate operational frequency bands r...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aac313

    authors: Islam MR,Tanaka T,Molla MKI

    更新日期:2018-08-01 00:00:00

  • Focused electrical stimulation using a single current source.

    abstract:OBJECTIVE:Cochlear implants, while providing significant benefits to recipients, remain limited due to broad neural activation. Focussed multipolar stimulation (FMP) is an advanced stimulation strategy that uses multiple current sources to produce highly focussed patterns of neural excitation in order to overcome these...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章

    doi:10.1088/1741-2552/aad0a5

    authors: Senn P,Shepherd RK,Fallon JB

    更新日期:2018-10-01 00:00:00