Abstract:
OBJECTIVE:In spite of intense theoretical and experimental investigations on electrical nerve stimulation, the influence of reversed ion currents on network activity during extracellular stimulation has not been investigated so far. APPROACH:Here, the impact of calcium current reversal on neurotransmitter release during subretinal stimulation was analyzed with a computational multi-compartment model of a retinal bipolar cell (BC) that was coupled with a four-pool model for the exocytosis from its ribbon synapses. Emphasis was laid on calcium channel dynamics and how these channels influence synaptic release. MAIN RESULTS:Stronger stimulation with anodic pulses caused transmembrane voltages above the Nernst potential of calcium in the terminals and, by this means, forced calcium ions to flow in the reversed direction from inside to the outside of the cell. Consequently, intracellular calcium concentration decreased resulting in a reduced vesicle release or preventing release at all. This mechanism is expected to lead to a pronounced ring-shaped pattern of exocytosis within a group of neighbored BCs when the stronger stimulated cells close to the electrode fail in releasing vesicles. SIGNIFICANCE:Stronger subretinal stimulation causes failure of synaptic exocytosis due to reversal of calcium flow into the extracellular space in cells close to the electrode.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Werginz P,Rattay Fdoi
10.1088/1741-2560/13/4/046013subject
Has Abstractpub_date
2016-08-01 00:00:00pages
046013issue
4eissn
1741-2560issn
1741-2552journal_volume
13pub_type
杂志文章abstract::In this work we address the use of realtime cortical recordings for the generation of coherent, reliable and robust motor activity in spinal-lesioned animals through selective intraspinal microstimulation (ISMS). The spinal cord of adult rats was hemisectioned and groups of multielectrodes were implanted in both the c...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/4/046008
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) are confronted with two fundamental challenges: (a) the uncertainty associated with decoding noisy brain signals, and (b) the need for co-adaptation between the brain and the interface so as to cooperatively achieve a common goal in a task. We seek to mitigate these challenges...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/6/066008
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:We have recently developed a prototype of a novel human-computer interface for assistive communication based on voluntary shifts of attention (gaze) from a far target to a near target associated with a decrease of pupil size (Pupillary Accommodative Response, PAR), an automatic vegetative response that can be...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab8e8f
更新日期:2020-04-29 00:00:00
abstract::The P300 speller is an example of a brain-computer interface that can restore functionality to victims of neuromuscular disorders. Although the most common application of this system has been communicating language, the properties and constraints of the linguistic domain have not to date been exploited when decoding b...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/1/016004
更新日期:2012-02-01 00:00:00
abstract::Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/3/003
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Schwann cells (SCs) are primary structural and functional cells in the peripheral nervous system. These cells play a crucial role in peripheral nerve regeneration by releasing neurotrophic factors. This study evaluated the neural differentiation potential effects of stem cells from human exfoliated deciduous ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/13/4/046005
更新日期:2016-08-01 00:00:00
abstract::The functional effects of selective hypoglossal nerve (HG) stimulation with a multi-contact peripheral nerve electrode were assessed using images of the upper airways and the tongue in anesthetized beagles. A biphasic pulse train of 50 Hz frequency and 2 s duration was applied through each one of the tripolar contact ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/2/4/002
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:Most brain-computer interfaces (BCIs) based on functional near-infrared spectroscopy (fNIRS) require that users perform mental tasks such as motor imagery, mental arithmetic, or music imagery to convey a message or to answer simple yes or no questions. These cognitive tasks usually have no direct association ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aae4b9
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Signal attenuation is a major problem facing intracortical sensors for chronic neuroprosthetic applications. Many studies suggest that failure is due to gliosis around the electrode tips, however, mechanical and material causes of failure are often overlooked. The purpose of this study was to investigate the ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/13/2/026003
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Somatic symptom disorder (SSD) is a reflection of medically unexplained physical symptoms that lead to distress and impairment in social and occupational functioning. SSD is phenomenologically diagnosed and its neurobiology remains unsolved. APPROACH:In this study, we performed hyper-parameter optimized clas...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab50b2
更新日期:2019-12-16 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the use of muscles appropriate for partial-hand prostheses with those typically used for complete hand devices and to determine whether differences in their underlying neural substrates translate to different levels of myoelectric control. APPROACH:We developed a no...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aacbfe
更新日期:2018-10-01 00:00:00
abstract::The aim of this paper is to use recent advances in the clinical understanding of the temporal evolution of seizure burden in neonates with hypoxic ischemic encephalopathy to improve the performance of automated detection algorithms. Probabilistic weights are designed from temporal locations of neonatal seizure events ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/4/046002
更新日期:2012-08-01 00:00:00
abstract::In a recent paper by Bradberry, Gentili and Contreras-Vidal published in Journal of Neural Engineering (2011, 8 036010), an interesting method for the control of a two-dimensional mouse cursor was proposed, which apparently attained excellent control and good speed with relatively simple techniques. We believe some of...
journal_title:Journal of neural engineering
pub_type: 评论,杂志文章
doi:10.1088/1741-2560/8/5/058001
更新日期:2011-10-01 00:00:00
abstract::Brain-computer interface (BCI) systems allow people with severe motor disabilities to communicate and interact with the external world. The P300 potential is one of the most used control signals for EEG-based BCIs. Classic P300-based BCIs work in a synchronous mode; the synchronous control assumes that the user is con...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/2/025025
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:The rapidly developing paradigm of closed-loop neuroscience has extensively employed brain rhythms as the signal forming real-time neurofeedback, triggering brain stimulation, or governing stimulus selection. However, the efficacy of brain rhythm contingent paradigms suffers from significant delays related to...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab890f
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVE:By means of subjective psychophysical methods, quality of transmitted speech has been decomposed into three perceptual dimensions named 'discontinuity' (F), 'noisiness' (N) and 'coloration' (C). Previous studies using electroencephalography (EEG) already reported effects of perceived intensity of single quali...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf122
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Fractional calculus plays a key role in the analysis of neural dynamics. In particular, fractional calculus has been recently exploited for analyzing complex biological systems and capturing intrinsic phenomena. Also, artificial neural networks have been shown to have complex neuronal dynamics and characteris...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab8dd6
更新日期:2020-06-12 00:00:00
abstract::Significant progress has been made in systems that interpret the electrical signals of the brain in order to control an actuator. One version of these systems senses neuronal extracellular action potentials with an array of up to 100 miniature probes inserted into the cortex. The impedance of each probe is high, so en...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/6/1/012001
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Penetrating cortical neural probe technologies allow investigators to record electrical signals in the brain. Implantation of probes results in acute tissue damage, and microglia density increases around implanted devices over weeks. However, the mechanisms underlying this encapsulation are not well understoo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/6/066001
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits. APPROACH:This progress was enabled by the team-based, inte...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2552/ab4869
更新日期:2019-11-12 00:00:00
abstract:OBJECTIVE:We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaa87a
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Due to low spatial resolution and poor signal-to-noise ratio of electroencephalogram (EEG), high accuracy classifications still suffer from lots of obstacles in the context of motor imagery (MI)-based brain-machine interface (BMI) systems. Particularly, it is extremely challenging to decode multiclass MI EEG ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aba7cd
更新日期:2020-08-11 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/4/046021
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:Medical implants made of non-biological materials provoke a chronic inflammatory response, resulting in the deposition of a collagenous scar tissue (ST) layer on their surface, that gradually thickens over time. This is a critical problem for neural interfaces. Scar build-up on electrodes results in a progres...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/13/2/026006
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:One of the main goals of brain-machine interface (BMI) research is to restore function to people with paralysis. Currently, multiple BMI design features are being investigated, based on various input modalities (externally applied and surgically implantable sensors) and output modalities (e.g. control of comp...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/4/043002
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods. The optimal threshold for extracting information from auditory cortex has yet to be ide...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab7c19
更新日期:2020-03-03 00:00:00
abstract::With the advent of new designs of visual prostheses for the blind, FDA is faced with developing guidance for evaluating their engineering, safety and patient performance. Visual prostheses are considered significant risk medical devices, and their use in human clinical trials must be approved by FDA under an investiga...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/4/1/S14
更新日期:2007-03-01 00:00:00
abstract::Implantable electrode arrays capable of recording and stimulating neural activity with high spatial and temporal resolution will provide a foundation for future brain computer interface technology. Currently, their clinical impact has been curtailed by a general lack of functional stability, which can be attributed to...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/4/003
更新日期:2008-12-01 00:00:00
abstract::Functional mapping of eloquent cortex is a common and necessary component of neurosurgical operative planning. Current electrical stimulation-based techniques are inefficient, can evoke seizures and are prone to false-negative results. Here, we present a novel cortical mapping system that extracts event-related neural...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/4/046018
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The goal of this study is to characterize the phenomenon of evoked tactile sensation (ETS) on the stump skin of forearm amputees using transcutaneous electrical nerve stimulation (TENS). APPROACH:We identified the projected finger map (PFM) of ETS on the stump skin in 11 forearm amputees, and compared percep...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/6/066002
更新日期:2015-12-01 00:00:00