Abstract:
:Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a series of related neuron models of varying complexity. Here, we use these models to build several half-center oscillators, and investigate how model complexity influences the robustness and flexibility of these oscillators. Our results indicate that model complexity has a significant effect on the robustness and flexibility of systems that incorporate neural models.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Sorensen ME,DeWeerth SPdoi
10.1088/1741-2560/4/3/003subject
Has Abstractpub_date
2007-09-01 00:00:00pages
189-96issue
3eissn
1741-2560issn
1741-2552pii
S1741-2560(07)35624-3journal_volume
4pub_type
杂志文章abstract::With the advent of new designs of visual prostheses for the blind, FDA is faced with developing guidance for evaluating their engineering, safety and patient performance. Visual prostheses are considered significant risk medical devices, and their use in human clinical trials must be approved by FDA under an investiga...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/4/1/S14
更新日期:2007-03-01 00:00:00
abstract::We hypothesize that a visual prosthesis capable of evoking high-resolution visual perceptions can be produced using high-electrode-count arrays of penetrating microelectrodes implanted into the primary visual cortex of a blind human subject. To explore this hypothesis, and as a prelude to human psychophysical experime...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/3/035001
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Electrocorticography (ECoG) based studies generally analyze features from specific frequency bands selected by manual evaluation of spectral power. However, the definition of these features can vary across subjects, cortical areas, tasks and across time for a given subject. We propose an autoencoder based app...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf13f
更新日期:2019-02-01 00:00:00
abstract::Deep brain stimulation (DBS) of the subthalamic nucleus with periodic, high-frequency pulse trains is an increasingly standard therapy for advanced Parkinson's disease. Here, we propose that a closed-loop global optimization algorithm may identify novel DBS waveforms that could be more effective than their high-freque...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/2/L03
更新日期:2007-06-01 00:00:00
abstract::We investigated the relationships of the firing rate and maximal recruitment threshold of motoneurons recorded during isometric contraction with the number of spindles in individual muscles. At force levels above 10% of maximal voluntary contraction, the firing rate was inversely related to the number of spindles in a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/1/016007
更新日期:2012-02-01 00:00:00
abstract::A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/3/036009
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Powered robotic prostheses create a need for natural-feeling user interfaces and robust control schemes. Here, we examined the ability of a nonlinear autoregressive model to continuously map the kinematics of a transtibial prosthesis and electromyographic (EMG) activity recorded within socket to the future es...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/11/5/056027
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Previous studies have shown that single-frequency impedance measurements could provide useful information about the distance between the neuroprosthesis and the retina. This work investigates the use of impedance spectroscopy in monitoring subretinal implantations of flexible micro-electrode arrays and focuse...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/4/046002
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool from the physical and engineering sciences that can provide insights r...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab6e8b
更新日期:2020-04-09 00:00:00
abstract:OBJECTIVE:Most recent steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) systems have used a single frequency for each target, so that a large number of targets require a large number of stimulus frequencies and therefore a wider frequency band. However, human beings show good SSVEP respo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/6/066009
更新日期:2013-12-01 00:00:00
abstract::One of the most important stages in a brain-computer interface (BCI) system is that of extracting features that can reliably discriminate data recorded during different user states. A popular technique used for feature extraction in BCIs is the common spatial patterns (CSP) method, which provides a set of spatial filt...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/4/045009
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Contemporary deep brain stimulation (DBS) for Parkinson's disease is delivered continuously, and adjustments based on patient's changing symptoms must be made manually by a trained clinician. Patients may be subjected to energy intensive settings at times when they are not needed, possibly resulting in stimul...
journal_title:Journal of neural engineering
pub_type: 临床试验,杂志文章
doi:10.1088/1741-2552/aabc9b
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Real-time closed-loop neural feedback control requires the analysis of action potential traces within several milliseconds after they have been recorded from the brain. The current generation of spike clustering algorithms were mostly designed for off-line use and also require a significant amount of computat...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab208c
更新日期:2019-07-30 00:00:00
abstract::We introduce algorithms and architectures for automatic spike detection and alignment that are designed for low power. Some of the algorithms are based on principal component analysis (PCA). Others employ a novel integral transform analysis and achieve 99% of the precision of a PCA detector, while requiring only 0.05%...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/3/1/004
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:The aim of this paper was to characterize brain non-stationarity during an auditory oddball task in schizophrenia (SCH). The level of non-stationarity was measured in the baseline and response windows of relevant tones in SCH patients and healthy controls. APPROACH:Event-related potentials were recorded from...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6e05
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Intramuscular electromyography (iEMG) signals, non-invasively recorded, directly from the muscles are used to diagnose various neuromuscular disorders/diseases, also to control rehabilitative and assistive robotic devices. iEMG signals are being potentially used in neurology, kinesiology, rehabilitation, and ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abcc7f
更新日期:2020-11-20 00:00:00
abstract::In models of electrical stimulation of the nervous system, the electric potential is typically calculated using the quasi-static approximation. The quasi-static approximation allows Maxwell's equations to be simplified by ignoring capacitive, inductive and wave propagation contributions to the potential. While this si...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/1/005
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:The past two decades have seen dramatic progress in our ability to model brain signals recorded by electroencephalography, functional near-infrared spectroscopy, etc., and to derive real-time estimates of user cognitive state, response, or intent for a variety of purposes: to restore communication by the seve...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/5/056014
更新日期:2013-10-01 00:00:00
abstract::Electrical stimulation of peripheral nerve activates large-diameter fibers before small ones. A physiological recruitment order, from small to large-diameter axons, is desirable in many applications. Previous studies using computer simulations showed that selective activation of small fibers could be achieved by resha...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/1/4/003
更新日期:2004-12-01 00:00:00
abstract::To study cell-field dynamics, physiologists simultaneously record local field potentials and the activity of individual cells from animals performing cognitive tasks, during various brain states or under pathological conditions. However, apart from spike shape and spike timing analyses, few studies have focused on elu...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/4/046024
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:Recording of neural signals from intact peripheral nerves in patients with spinal cord injury or stroke survivors offers the possibility for the development of closed-loop sensorimotor prostheses. Nerve cuffs have been found to provide stable recordings from peripheral nerves for prolonged periods of time. Ho...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aabca0
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Functions ascribed to the hippocampal sub-regions for encoding episodic memories include the separation of activity patterns propagated from the entorhinal cortex (EC) into the dentate gyrus (DG) and pattern completion in CA3 region. Since a direct assessment of these functions is lacking at the level of spec...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aabc20
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. AP...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abb63a
更新日期:2020-10-30 00:00:00
abstract:OBJECTIVE:In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with tetraplegia using a brain-machine interface (BMI). The current study, in the same subject, immediately followed the previous work...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/1/016011
更新日期:2015-02-01 00:00:00
abstract::The functional effects of selective hypoglossal nerve (HG) stimulation with a multi-contact peripheral nerve electrode were assessed using images of the upper airways and the tongue in anesthetized beagles. A biphasic pulse train of 50 Hz frequency and 2 s duration was applied through each one of the tripolar contact ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/2/4/002
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:While the positive correlation between impedance and noise of microelectrodes is well known, their quantitative relationship is too rarely described. Knowledge of this relationship provides useful information for both microsystems engineers and electrophysiologists. APPROACH:We discuss the physical basis of ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abb3b4
更新日期:2020-10-15 00:00:00
abstract:OBJECTIVE:Damage to the brain, as a result of various medical conditions, impacts the everyday life of patients and there is still no complete cure to neurological disorders. Neuroprostheses that can functionally replace the damaged neural circuit have recently emerged as a possible solution to these problems. Here we ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa98e9
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Electroencephalography (EEG) recorded during transcranial alternating current simulation (tACS) is highly desirable in order to investigate brain dynamics during stimulation, but is corrupted by large amplitude stimulation artefacts. Artefact removal algorithms have been presented previously, but with substan...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab58a3
更新日期:2020-01-24 00:00:00
abstract:OBJECTIVE:We presented a comparative study on the training methodologies of a convolutional neural network (CNN) for the detection of steady-state visually evoked potentials (SSVEP). Two training scenarios were also compared: user-independent (UI) training and user-dependent (UD) training. APPROACH:The CNN was trained...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab6a67
更新日期:2020-04-08 00:00:00
abstract:OBJECTIVE:Signal attenuation is a major problem facing intracortical sensors for chronic neuroprosthetic applications. Many studies suggest that failure is due to gliosis around the electrode tips, however, mechanical and material causes of failure are often overlooked. The purpose of this study was to investigate the ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/13/2/026003
更新日期:2016-04-01 00:00:00