Adaptive deep brain stimulation for Parkinson's disease using motor cortex sensing.

abstract：OBJECTIVE:Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technolog...

journal_title：Journal of neural engineering

authors： Shepherd RK,Villalobos J,Burns O,Nayagam DAX

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The majority of near-infrared spectroscopy (NIRS) brain-computer interface (BCI) studies have investigated binary classification problems. Limited work has considered differentiation of more than two mental states, or multi-class differentiation of higher-level cognitive tasks using measurements outside of th...

journal_title：Journal of neural engineering

authors： C Schudlo L,Chau T

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Brains, like other physical devices, are inherently noisy. This source of variability is large, to the extent that internal noise often impacts human sensory processing more than externally induced (stimulus-driven) perturbations. Despite the fundamental nature of this phenomenon, its statistical distribution...

journal_title：Journal of neural engineering

authors： Neri P

更新日期：2013-02-01 00:00:00

abstract：:In this work we address the use of realtime cortical recordings for the generation of coherent, reliable and robust motor activity in spinal-lesioned animals through selective intraspinal microstimulation (ISMS). The spinal cord of adult rats was hemisectioned and groups of multielectrodes were implanted in both the c...

journal_title：Journal of neural engineering

authors： Panetsos F,Sanchez-Jimenez A,Torets C,Largo C,Micera S

更新日期：2011-08-01 00:00:00

abstract：:In the study of the spreading depression (SD) wave phenomenon and its dynamics, it is necessary to describe the ionic movements along the extracellular space, as well as between this and the intracellular space. In both cases, the ionic movement includes a double coupling involving the concentration and the potential ...

journal_title：Journal of neural engineering

authors： Teixeira HZ,de Almeida AC,Infantosi AF,Vasconcelos MA,Duarte MA

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:State of the art brain-computer interface (BCI) research focuses on improving individual components such as the application or the decoder that converts the user's brain activity to control signals. In this study, we investigate the interaction between these components in the P300 speller, a BCI for communica...

journal_title：Journal of neural engineering

authors： Verhoeven T,Buteneers P,Wiersema JR,Dambre J,Kindermans PJ

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Most brain-computer interfaces (BCIs) based on functional near-infrared spectroscopy (fNIRS) require that users perform mental tasks such as motor imagery, mental arithmetic, or music imagery to convey a message or to answer simple yes or no questions. These cognitive tasks usually have no direct association ...

journal_title：Journal of neural engineering

authors： Rezazadeh Sereshkeh A,Yousefi R,Wong AT,Chau T

更新日期：2019-02-01 00:00:00

abstract：:Automatic spike sorting is a prerequisite for neuroscience research on multichannel extracellular recordings of neuronal activity. A novel spike sorting framework, combining efficient feature extraction and an unsupervised clustering method, is described here. Wavelet transform (WT) is adopted to extract features from...

journal_title：Journal of neural engineering

authors： Lai HY,Chen YY,Lin SH,Lo YC,Tsang S,Chen SY,Zhao WT,Chao WH,Chang YC,Wu R,Shih YY,Tsai ST,Jaw FS

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Advances in electrode technology have facilitated the development of neuroprostheses for restoring motor/sensory function in disabled individuals. Information extracted from a whole nerve, recorded using cuffs, can provide signals that control the operation of neuroprostheses. However, the amount of informati...

journal_title：Journal of neural engineering

authors： Sabetian P,Yoo PB

更新日期：2020-01-28 00:00:00

abstract：OBJECTIVE:Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods. The optimal threshold for extracting information from auditory cortex has yet to be ide...

journal_title：Journal of neural engineering

authors： Bigelow J,Malone B

更新日期：2020-03-03 00:00:00

abstract：OBJECTIVE:Despite their increasing use and public health importance, little is known about the consistency and variability of the quantitative features of baseline electroencephalography (EEG) measurements in healthy individuals and populations. This study aims to investigate population consistency of EEG features. AP...

journal_title：Journal of neural engineering

authors： Nahmias DO,Kontson KL,Soltysik DA,Civillico EF

更新日期：2019-11-12 00:00:00

abstract：:We present a micromachined 252-channel ECoG (electrocorticogram)-electrode array, which is made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths. The array subtends an area of approximately 35 mm by 60 mm and is designed to cover large parts of a hemisphere of a macaq...

journal_title：Journal of neural engineering

authors： Rubehn B,Bosman C,Oostenveld R,Fries P,Stieglitz T

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Haptic feedback is crucial when we manipulate objects. Information pertaining to an object's stiffness in particular can help facilitate fine motor control. In this study, we seek to determine whether objects of different stiffness levels can be recognized using haptic feedback provided by transcutaneous elec...

journal_title：Journal of neural engineering

authors： Vargas L,Shin H,Huang HH,Zhu Y,Hu X

更新日期：2019-12-05 00:00:00

abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus with periodic, high-frequency pulse trains is an increasingly standard therapy for advanced Parkinson's disease. Here, we propose that a closed-loop global optimization algorithm may identify novel DBS waveforms that could be more effective than their high-freque...

journal_title：Journal of neural engineering

authors： Feng XJ,Greenwald B,Rabitz H,Shea-Brown E,Kosut R

更新日期：2007-06-01 00:00:00

abstract：:The extraction of distinctly separable features from electroencephalogram (EEG) is one of the main challenges in designing a brain-computer interface (BCI). Existing feature extraction techniques for a BCI are mostly developed based on traditional signal processing techniques assuming that the signal is Gaussian and h...

journal_title：Journal of neural engineering

authors： Shahid S,Prasad G

更新日期：2011-04-01 00:00:00

abstract：:The modern multi-channel cochlear implant is widely considered to be the most successful neural prosthesis owing to its ability to restore partial hearing to post-lingually deafened adults and to allow essentially normal language development in pre-lingually deafened children. However, the implant performance varies g...

journal_title：Journal of neural engineering

authors： Tang Q,Benítez R,Zeng FG

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Somatic symptom disorder (SSD) is a reflection of medically unexplained physical symptoms that lead to distress and impairment in social and occupational functioning. SSD is phenomenologically diagnosed and its neurobiology remains unsolved. APPROACH:In this study, we performed hyper-parameter optimized clas...

journal_title：Journal of neural engineering

authors： Eken A,Çolak B,Bal NB,Kuşman A,Kızılpınar SÇ,Akaslan DS,Baskak B

更新日期：2019-12-16 00:00:00

abstract：OBJECTIVE:Analyzing and interpreting the activity of a heterogeneous population of neurons can be challenging, especially as the number of neurons, experimental trials, and experimental conditions increases. One approach is to extract a set of latent variables that succinctly captures the prominent co-fluctuation patte...

journal_title：Journal of neural engineering

authors： Cowley BR,Kaufman MT,Butler ZS,Churchland MM,Ryu SI,Shenoy KV,Yu BM

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Visual prostheses are designed to restore partial functional vision in patients with total vision loss. Retinal visual prostheses provide limited capabilities as a result of low resolution, limited field of view and poor dynamic range. Understanding the influence of these parameters in the perception results ...

journal_title：Journal of neural engineering

authors： Sanchez-Garcia M,Martinez-Cantin R,Bermudez-Cameo J,Guerrero JJ

更新日期：2020-10-08 00:00:00

abstract：OBJECTIVE:Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. APPROACH:Multi-contact cuff electrode...

journal_title：Journal of neural engineering

authors： Tan DW,Schiefer MA,Keith MW,Anderson JR,Tyler DJ

更新日期：2015-04-01 00:00:00

abstract：:In this paper, we propose a simple and straightforward algorithm for neural spike sorting. The algorithm is based on the observation that the distribution of a neural signal largely deviates from the uniform distribution and is rather unimodal. The detected spikes to be sorted are first processed with some feature ext...

journal_title：Journal of neural engineering

authors： Tiganj Z,Mboup M

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Intracortical brain-machine interfaces (iBMIs) aim to restore efficient communication and movement ability for paralyzed patients. However, frequent recalibration is required for consistency and reliability, and every recalibration will require relatively large most current sample set. The aim in this study i...

journal_title：Journal of neural engineering

authors： Zhang P,Ma X,Chen L,Zhou J,Wang C,Li W,He J

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to compare the use of muscles appropriate for partial-hand prostheses with those typically used for complete hand devices and to determine whether differences in their underlying neural substrates translate to different levels of myoelectric control. APPROACH:We developed a no...

journal_title：Journal of neural engineering

authors： Dyson M,Barnes J,Nazarpour K

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Electroencephalography (EEG) offers a unique opportunity to study human neural activity non-invasively with millisecond resolution using minimal equipment in or outside of a lab setting. EEG can be combined with a number of techniques for closed-loop experiments, where external devices are driven by specific ...

journal_title：Journal of neural engineering

authors： Black C,Voigts J,Agrawal U,Ladow M,Santoyo J,Moore C,Jones S

更新日期：2017-06-01 00:00:00

abstract：:Hybrid electro-optical neural stimulation is a novel paradigm combining the advantages of optical and electrical stimulation techniques while reducing their respective limitations. However, in order to fulfill its promise, this technique requires reduced variability and improved reproducibility. Here we used a compara...

journal_title：Journal of neural engineering

authors： Duke AR,Lu H,Jenkins MW,Chiel HJ,Jansen ED

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:A signal-based metric for assessment of accuracy of motor unit (MU) identification from high-density surface electromyograms (EMG) is introduced. This metric, so-called pulse-to-noise-ratio (PNR), is computationally efficient, does not require any additional experimental costs and can be applied to every MU t...

journal_title：Journal of neural engineering

authors： Holobar A,Minetto MA,Farina D

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits. APPROACH:This progress was enabled by the team-based, inte...

journal_title：Journal of neural engineering

authors： Ereifej ES,Shell CE,Schofield JS,Charkhkar H,Cuberovic I,Dorval AD,Graczyk EL,Kozai TDY,Otto KJ,Tyler DJ,Welle CG,Widge AS,Zariffa J,Moritz CT,Bourbeau DJ,Marasco PD

更新日期：2019-11-12 00:00:00

abstract：:Golgi tendon organs (GTOs) located in the skeletal muscles provide the central nervous system with information about muscle tension. The ensemble firing of all GTO receptors in the muscle has been hypothesized to represent a reliable measure of the whole muscle force but the precision and accuracy of that information ...

journal_title：Journal of neural engineering

authors： Mileusnic MP,Loeb GE

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...

journal_title：Journal of neural engineering

authors： Samek W,Nakajima S,Kawanabe M,Müller KR

更新日期：2017-12-01 00:00:00

abstract：:Glutamate spillover is thought to play a significant role in increasing neural transmission at the mossy fiber/granule cell cerebellar glomerulus. Glutamate spillover has been shown to activate AMPA receptors at the glomerulus, and here we complete the characterization of spillover at the glomerulus by investigating t...

journal_title：Journal of neural engineering

authors： Mitchell CS,Feng SS,Lee RH

更新日期：2007-09-01 00:00:00