Abstract:
OBJECTIVE:Damage to the brain, as a result of various medical conditions, impacts the everyday life of patients and there is still no complete cure to neurological disorders. Neuroprostheses that can functionally replace the damaged neural circuit have recently emerged as a possible solution to these problems. Here we describe the development of a real-time cerebellar neuroprosthetic system to substitute neural function in cerebellar circuitry for learning delay eyeblink conditioning (DEC). APPROACH:The system was empowered by a biologically realistic spiking neural network (SNN) model of the cerebellar neural circuit, which considers the neuronal population and anatomical connectivity of the network. The model simulated synaptic plasticity critical for learning DEC. This SNN model was carefully implemented on a field programmable gate array (FPGA) platform for real-time simulation. This hardware system was interfaced in in vivo experiments with anesthetized rats and it used neural spikes recorded online from the animal to learn and trigger conditioned eyeblink in the animal during training. MAIN RESULTS:This rat-FPGA hybrid system was able to process neuronal spikes in real-time with an embedded cerebellum model of ~10 000 neurons and reproduce learning of DEC with different inter-stimulus intervals. Our results validated that the system performance is physiologically relevant at both the neural (firing pattern) and behavioral (eyeblink pattern) levels. SIGNIFICANCE:This integrated system provides the sufficient computation power for mimicking the cerebellar circuit in real-time. The system interacts with the biological system naturally at the spike level and can be generalized for including other neural components (neuron types and plasticity) and neural functions for potential neuroprosthetic applications.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Xu T,Xiao N,Zhai X,Kwan Chan P,Tin Cdoi
10.1088/1741-2552/aa98e9subject
Has Abstractpub_date
2018-02-01 00:00:00pages
016021issue
1eissn
1741-2560issn
1741-2552journal_volume
15pub_type
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/3/3/R01
更新日期:2006-09-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aabd5d
更新日期:2018-08-01 00:00:00
abstract::Human trials of prototype visual prostheses have successfully elicited visual percepts (phosphenes) in the visual field of implant recipients blinded through retinitis pigmentosa and age-related macular degeneration. Researchers are progressing rapidly towards a device that utilizes individual phosphenes as the elemen...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/6/3/035009
更新日期:2009-06-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abcc7f
更新日期:2020-11-20 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/3/007
更新日期:2008-09-01 00:00:00
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journal_title:Journal of neural engineering
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doi:10.1088/1741-2560/12/2/026002
更新日期:2015-04-01 00:00:00
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更新日期:2020-04-09 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf13f
更新日期:2019-02-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/3/036001
更新日期:2009-06-01 00:00:00
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journal_title:Journal of neural engineering
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doi:10.1088/1741-2560/1/4/003
更新日期:2004-12-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/5/056014
更新日期:2013-10-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab5551
更新日期:2020-01-28 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/11/5/056027
更新日期:2014-10-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/4/046021
更新日期:2015-08-01 00:00:00
abstract::Microscopic aggregation assay and impedance sensing (IS) were used to monitor a change in in vitro neuron-neuron adhesion in response to blocking of cell adhesion molecules. By blocking neuron-neuron adhesion, migration and aggregation of neuronal cells can be inhibited. This leads to better control of spatial arrange...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/5/056003
更新日期:2010-10-01 00:00:00
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journal_title:Journal of neural engineering
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doi:10.1088/1741-2552/abd463
更新日期:2020-12-16 00:00:00
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更新日期:2017-08-01 00:00:00
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doi:10.1088/1741-2552/ab58a3
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of neural engineering
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更新日期:2020-12-03 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab208c
更新日期:2019-07-30 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of neural engineering
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00