Abstract:
OBJECTIVE:Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. APPROACH:Multi-contact cuff electrodes were implanted in the median, ulnar, and radial nerves of the upper-limb. MAIN RESULTS:Nerve stimulation produced a selective sensory response on 19 of 20 contacts and 16 of 16 contacts in subjects 1 and 2, respectively. Stimulation elicited multiple, distinct percept areas on the phantom and residual limb. Consistent threshold, impedance, and percept areas have demonstrated that the neural interface is stable for the duration of this on-going, chronic study. SIGNIFICANCE:We have achieved selective nerve response from multi-contact cuff electrodes by demonstrating characteristic percept areas and thresholds for each contact. Selective sensory response remains consistent in two upper-limb amputees for 1 and 2 years, the longest multi-contact sensory feedback system to date. Our approach demonstrates selectivity and stability can be achieved through an extraneural interface, which can provide sensory feedback to amputees.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Tan DW,Schiefer MA,Keith MW,Anderson JR,Tyler DJdoi
10.1088/1741-2560/12/2/026002subject
Has Abstractpub_date
2015-04-01 00:00:00pages
026002issue
2eissn
1741-2560issn
1741-2552journal_volume
12pub_type
杂志文章abstract::Functional electrical stimulation (FES), the coordinated electrical activation of multiple muscles, has been used to restore arm and hand function in people with paralysis. User interfaces for such systems typically derive commands from mechanically unrelated parts of the body with retained volitional control, and are...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/3/034003
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Damage to the brain, as a result of various medical conditions, impacts the everyday life of patients and there is still no complete cure to neurological disorders. Neuroprostheses that can functionally replace the damaged neural circuit have recently emerged as a possible solution to these problems. Here we ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa98e9
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:High-fidelity vibrokinetic (HFVK) technology is widely used to enhance the immersiveness of audiovisual (AV) entertainment experiences. However, despite evidence that HFVK technology does subjectively enhance AV immersion, the underlying mechanism has not been clarified. Neurophysiological studies could provi...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abaca2
更新日期:2020-09-26 00:00:00
abstract::We introduce algorithms and architectures for automatic spike detection and alignment that are designed for low power. Some of the algorithms are based on principal component analysis (PCA). Others employ a novel integral transform analysis and achieve 99% of the precision of a PCA detector, while requiring only 0.05%...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/3/1/004
更新日期:2006-03-01 00:00:00
abstract::Some issues in neuroscience can be addressed by building robot models of biological sensorimotor systems. What we can conclude from building models or simulations, however, is determined by a number of factors in addition to the central hypothesis we intend to test. These include the way in which the hypothesis is rep...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/3/3/R01
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:Low-intensity transcranial ultrasound stimulation (TUS) is emerging as a non-invasive brain stimulation technique with superior spatial resolution and the ability to reach deep brain areas. Medical image-based computational modeling could be an important tool for individualized TUS dose control and targeting ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab98dc
更新日期:2020-07-13 00:00:00
abstract:OBJECTIVE:Advances in electrode technology have facilitated the development of neuroprostheses for restoring motor/sensory function in disabled individuals. Information extracted from a whole nerve, recorded using cuffs, can provide signals that control the operation of neuroprostheses. However, the amount of informati...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab5551
更新日期:2020-01-28 00:00:00
abstract::After extended implantation times, traditional intracortical neural probes exhibit a foreign-body reaction characterized by a reactive glial sheath that has been associated with increased system impedance and signal deterioration. Previously, we have proposed that the local in vivo polymerization of an electronically ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/11/2/026005
更新日期:2014-04-01 00:00:00
abstract::In models of electrical stimulation of the nervous system, the electric potential is typically calculated using the quasi-static approximation. The quasi-static approximation allows Maxwell's equations to be simplified by ignoring capacitive, inductive and wave propagation contributions to the potential. While this si...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/1/005
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Ultrasounds (US) use in neural engineering is so far mainly limited to ablation through high intensity focused ultrasound, but interesting preliminary results show that low intensity low frequency ultrasound could be used instead to modulate neural activity. However, the extent of this modulatory ability of U...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abae8b
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVE:Differential measurement of efferent and afferent peripheral nerve activity offers a promising means of improving the clinical utility of implantable neuroprostheses. The tripolar nerve cuff electrode has historically served as the gold standard for achieving high signal-to-noise ratios (SNRs) of the recordin...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6407
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6213
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:The objective of this work is to present gumpy, a new free and open source Python toolbox designed for hybrid brain-computer interface (BCI). APPROACH:Gumpy provides state-of-the-art algorithms and includes a rich selection of signal processing methods that have been employed by the BCI community over the la...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aae186
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Two-dimensional (2D) movement control is an important issue in brain-computer interfaces (BCIs) research because being able to move, for example, a cursor with the brain will enable patients with motor disabilities to control their environment. However, it is still a challenge to continuously control 2D movem...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/4/046021
更新日期:2015-08-01 00:00:00
abstract::The extraction of distinctly separable features from electroencephalogram (EEG) is one of the main challenges in designing a brain-computer interface (BCI). Existing feature extraction techniques for a BCI are mostly developed based on traditional signal processing techniques assuming that the signal is Gaussian and h...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/2/025014
更新日期:2011-04-01 00:00:00
abstract::We investigated the relationships of the firing rate and maximal recruitment threshold of motoneurons recorded during isometric contraction with the number of spindles in individual muscles. At force levels above 10% of maximal voluntary contraction, the firing rate was inversely related to the number of spindles in a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/1/016007
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Currently commercially available nerve conduits have demonstrated suboptimal clinical efficacy in repairing peripheral nerve defects. Although tissue-engineered nerve grafts (TENGs) with sustained release of neurotrophic factors (NTFs) are experimentally proved to be more effective than these blank conduits, ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab17a0
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technolog...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aac43c
更新日期:2018-08-01 00:00:00
abstract::We describe a brain-computer interface for controlling a humanoid robot directly using brain signals obtained non-invasively from the scalp through electroencephalography (EEG). EEG has previously been used for tasks such as controlling a cursor and spelling a word, but it has been regarded as an unlikely candidate fo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/5/2/012
更新日期:2008-06-01 00:00:00
abstract::Golgi tendon organs (GTOs) located in the skeletal muscles provide the central nervous system with information about muscle tension. The ensemble firing of all GTO receptors in the muscle has been hypothesized to represent a reliable measure of the whole muscle force but the precision and accuracy of that information ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/3/036001
更新日期:2009-06-01 00:00:00
abstract::Microscopic aggregation assay and impedance sensing (IS) were used to monitor a change in in vitro neuron-neuron adhesion in response to blocking of cell adhesion molecules. By blocking neuron-neuron adhesion, migration and aggregation of neuronal cells can be inhibited. This leads to better control of spatial arrange...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/5/056003
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:The various parameters that define a hand movement such as its trajectory, speed, etc, are encoded in distinct brain activities. Decoding this information from neurophysiological recordings is a less explored area of brain-computer interface (BCI) research. Applying non-invasive recordings such as electroence...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/6/066019
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. In cortic...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aafbfb
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease and dystonia improves motor symptoms and quality of life. Traditionally, pallidal borders have been demarcated by electrophysiological microelectrode recordings (MERs) during DBS surgery. How...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab53ac
更新日期:2020-01-06 00:00:00
abstract::Brain-computer interface (BCI) systems do not work for all users. This article introduces a novel combination of tasks that could inspire BCI systems that are more accurate than conventional BCIs, especially for users who cannot attain accuracy adequate for effective communication. Subjects performed tasks typically u...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/7/2/026007
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) are confronted with two fundamental challenges: (a) the uncertainty associated with decoding noisy brain signals, and (b) the need for co-adaptation between the brain and the interface so as to cooperatively achieve a common goal in a task. We seek to mitigate these challenges...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/6/066008
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Spinal cord stimulation (SCS) is a common neurostimulation therapy to treat chronic pain. Computational models represent a valuable tool to study the potential mechanisms of action of SCS and to optimize the design and implementation of SCS technologies. However, it is imperative that these computational mode...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab8fc4
更新日期:2020-06-12 00:00:00
abstract:OBJECTIVE:Neuromusculoskeletal models involve many subject-specific physiological parameters that need to be adjusted to adequately represent muscle properties. Traditionally, neuromusculoskeletal models have been calibrated with a forward-inverse dynamic optimization which is time-consuming and unfeasible for rehabili...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa58f5
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Sleep spindles in the electroencephalogram (EEG) are significant in sleep analysis related to cognitive functions and neurological diseases, and thus are of great clinical interests. An automatic sleep spindle detection algorithm could help decrease the workload of visual inspection by sleep clinicians. APPR...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abd463
更新日期:2020-12-16 00:00:00
abstract:OBJECTIVE:The past two decades have seen dramatic progress in our ability to model brain signals recorded by electroencephalography, functional near-infrared spectroscopy, etc., and to derive real-time estimates of user cognitive state, response, or intent for a variety of purposes: to restore communication by the seve...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/5/056014
更新日期:2013-10-01 00:00:00