Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.

Abstract:

OBJECTIVE:This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. APPROACH:This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision. MAIN RESULTS:Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain. SIGNIFICANCE:This work suggests that 4D tABI may emerge as a revolutionary modality for real-time high-resolution mapping of neuronal currents for the purpose of monitoring, staging, and guiding treatment of epilepsy and other brain disorders characterized by abnormal rhythms.

journal_name

J Neural Eng

authors

Barragan A,Preston C,Alvarez A,Bera T,Qin Y,Weinand M,Kasoff W,Witte RS

doi

10.1088/1741-2552/abb63a

subject

Has Abstract

pub_date

2020-10-30 00:00:00

pages

056040

issue

5

eissn

1741-2560

issn

1741-2552

journal_volume

17

pub_type

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