Rhythmic modulation of thalamic oscillations depends on intrinsic cellular dynamics.


OBJECTIVE:Rhythmic brain stimulation has emerged as a powerful tool to modulate cognition and to target pathological oscillations related to neurological and psychiatric disorders. However, we lack a systematic understanding of how periodic stimulation interacts with endogenous neural activity as a function of the brain state and target. APPROACH:To address this critical issue, we applied periodic stimulation to a unified biophysical thalamic network model that generates multiple distinct oscillations, and examined thoroughly the impact of rhythmic stimulation on different oscillatory states. MAIN RESULTS:We found that rhythmic perturbation induces four basic response mechanisms: entrainment, acceleration, resonance and suppression. Importantly, the appearance and expression of these mechanisms depend highly on the intrinsic cellular dynamics in each state. Specifically, the low-threshold bursting of thalamocortical cells (TCs) in delta (δ) oscillation renders the network relatively insensitive to entrainment; the high-threshold bursting of TCs in alpha (α) oscillation leads to widespread oscillation suppression while the tonic spiking of TC cells in gamma (γ) oscillation results in prominent entrainment and resonance. In addition, we observed entrainment discontinuity during α oscillation that is mediated by firing pattern switching of high-threshold bursting TC cells. Furthermore, we demonstrate that direct excitatory stimulation of the lateral geniculate nucleus (LGN) entrains thalamic oscillations via an asymmetric Arnold tongue that favors higher frequency entrainment and resonance, while stimulation of the inhibitory circuit, the reticular nucleus, induces much weaker and more symmetric entrainment and resonance. These results support the notion that rhythmic stimulation engages brain oscillations in a state- and target-dependent manner. SIGNIFICANCE:Overall, our study provides, for the first time, insights into how the biophysics of thalamic oscillations guide the emergence of complex, state-dependent mechanisms of target engagement, which can be leveraged for the future rational design of novel therapeutic stimulation modalities.


J Neural Eng


Li G,Henriquez CS,Fröhlich F




Has Abstract


2019-02-01 00:00:00












  • Real-time machine learning classification of pallidal borders during deep brain stimulation surgery.

    abstract:OBJECTIVE:Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease and dystonia improves motor symptoms and quality of life. Traditionally, pallidal borders have been demarcated by electrophysiological microelectrode recordings (MERs) during DBS surgery. How...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Valsky D,Blackwell KT,Tamir I,Eitan R,Bergman H,Israel Z

    更新日期:2020-01-06 00:00:00

  • Autoencoders for learning template spectrograms in electrocorticographic signals.

    abstract:OBJECTIVE:Electrocorticography (ECoG) based studies generally analyze features from specific frequency bands selected by manual evaluation of spectral power. However, the definition of these features can vary across subjects, cortical areas, tasks and across time for a given subject. We propose an autoencoder based app...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Pailla T,Miller KJ,Gilja V

    更新日期:2019-02-01 00:00:00

  • Assessing altered motor unit recruitment patterns in paretic muscles of stroke survivors using surface electromyography.

    abstract:OBJECTIVE:The advancement of surface electromyogram (sEMG) recording and signal processing techniques has allowed us to characterize the recruitment properties of a substantial population of motor units (MUs) non-invasively. Here we seek to determine whether MU recruitment properties are modified in paretic muscles of ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Hu X,Suresh AK,Rymer WZ,Suresh NL

    更新日期:2015-12-01 00:00:00

  • Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation.

    abstract:OBJECTIVE:Given current clinical interest in vagus nerve stimulation (VNS), there are surprisingly few studies characterizing the anatomy of the vagus nerve in large animal models as it pertains to on-and off-target engagement of local fibers. We sought to address this gap by evaluating vagal anatomy in the pig, whose ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Settell ML,Pelot NA,Knudsen BE,Dingle AM,McConico AL,Nicolai EN,Trevathan JK,Ezzell JA,Ross EK,Gustafson KJ,Shoffstall AJ,Williams JC,Zeng W,Poore SO,Populin LC,Suminski AJ,Grill WM,Ludwig KA

    更新日期:2020-04-09 00:00:00

  • The noise and impedance of microelectrodes.

    abstract:OBJECTIVE:While the positive correlation between impedance and noise of microelectrodes is well known, their quantitative relationship is too rarely described. Knowledge of this relationship provides useful information for both microsystems engineers and electrophysiologists. APPROACH:We discuss the physical basis of ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Mierzejewski M,Steins H,Kshirsagar P,Jones PD

    更新日期:2020-10-15 00:00:00

  • Stem cells from human exfoliated deciduous teeth differentiate toward neural cells in a medium dynamically cultured with Schwann cells in a series of polydimethylsiloxanes scaffolds.

    abstract:OBJECTIVE:Schwann cells (SCs) are primary structural and functional cells in the peripheral nervous system. These cells play a crucial role in peripheral nerve regeneration by releasing neurotrophic factors. This study evaluated the neural differentiation potential effects of stem cells from human exfoliated deciduous ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Su WT,Pan YJ

    更新日期:2016-08-01 00:00:00

  • Ensembles of adaptive spatial filters increase BCI performance: an online evaluation.

    abstract:OBJECTIVE:In electroencephalographic (EEG) data, signals from distinct sources within the brain are widely spread by volume conduction and superimposed such that sensors receive mixtures of a multitude of signals. This reduction of spatial information strongly hampers single-trial analysis of EEG data as, for example, ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Sannelli C,Vidaurre C,Müller KR,Blankertz B

    更新日期:2016-08-01 00:00:00

  • Feasibility of differentially measuring afferent and efferent neural activity with a single nerve cuff electrode.

    abstract:OBJECTIVE:Advances in electrode technology have facilitated the development of neuroprostheses for restoring motor/sensory function in disabled individuals. Information extracted from a whole nerve, recorded using cuffs, can provide signals that control the operation of neuroprostheses. However, the amount of informati...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Sabetian P,Yoo PB

    更新日期:2020-01-28 00:00:00

  • Performance measurement for brain-computer or brain-machine interfaces: a tutorial.

    abstract:OBJECTIVE:Brain-computer interfaces (BCIs) have the potential to be valuable clinical tools. However, the varied nature of BCIs, combined with the large number of laboratories participating in BCI research, makes uniform performance reporting difficult. To address this situation, we present a tutorial on performance me...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Thompson DE,Quitadamo LR,Mainardi L,Laghari KU,Gao S,Kindermans PJ,Simeral JD,Fazel-Rezai R,Matteucci M,Falk TH,Bianchi L,Chestek CA,Huggins JE

    更新日期:2014-06-01 00:00:00

  • Spatial and temporal variability in response to hybrid electro-optical stimulation.

    abstract::Hybrid electro-optical neural stimulation is a novel paradigm combining the advantages of optical and electrical stimulation techniques while reducing their respective limitations. However, in order to fulfill its promise, this technique requires reduced variability and improved reproducibility. Here we used a compara...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Duke AR,Lu H,Jenkins MW,Chiel HJ,Jansen ED

    更新日期:2012-06-01 00:00:00

  • A Correlation-Driven Mapping For Deep Learning application in detecting artifacts within the EEG.

    abstract:OBJECTIVE:When developing approaches for automatic preprocessing of electroencephalogram (EEG) signals in non-isolated demanding environment such as intensive care unit (ICU) or even outdoor environment, one of the major concerns is varying nature of characteristics of different artifacts in time, frequency and spatial...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Bahador N,Erikson K,Laurila J,Koskenkari J,Ala-Kokko T,Kortelainen J

    更新日期:2020-10-15 00:00:00

  • The analytic common spatial patterns method for EEG-based BCI data.

    abstract::One of the most important stages in a brain-computer interface (BCI) system is that of extracting features that can reliably discriminate data recorded during different user states. A popular technique used for feature extraction in BCIs is the common spatial patterns (CSP) method, which provides a set of spatial filt...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Falzon O,Camilleri KP,Muscat J

    更新日期:2012-08-01 00:00:00

  • Suppression of scarring in peripheral nerve implants by drug elution.

    abstract:OBJECTIVE:Medical implants made of non-biological materials provoke a chronic inflammatory response, resulting in the deposition of a collagenous scar tissue (ST) layer on their surface, that gradually thickens over time. This is a critical problem for neural interfaces. Scar build-up on electrodes results in a progres...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: FitzGerald JJ

    更新日期:2016-04-01 00:00:00

  • Improved mobility performance with an artificial vision therapy system using a thermal sensor.

    abstract:OBJECTIVE:To evaluate the benefit of integrating thermal imaging into an artificial vision therapy system, the Argus II retinal prosthesis, in simplifying a complex scene and improving mobility performance in the presence of other persons. APPROACH:Four Argus II retinal implant users were evaluated on two tasks: to lo...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: He Y,Sun SY,Roy A,Caspi A,Montezuma SR

    更新日期:2020-08-04 00:00:00

  • Analysis of the quasi-static approximation for calculating potentials generated by neural stimulation.

    abstract::In models of electrical stimulation of the nervous system, the electric potential is typically calculated using the quasi-static approximation. The quasi-static approximation allows Maxwell's equations to be simplified by ignoring capacitive, inductive and wave propagation contributions to the potential. While this si...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Bossetti CA,Birdno MJ,Grill WM

    更新日期:2008-03-01 00:00:00

  • Interleaved intramuscular stimulation with minimally overlapping electrodes evokes smooth and fatigue resistant forces.

    abstract:OBJECTIVE:It is known that multi-site interleaved stimulation generates less muscle fatigue compared to single-site synchronous stimulation. However, in the limited number of studies in which intramuscular electrodes were used, the fatigue reduction associated with interleaved stimulation could not consistently be achi...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Eladly A,Del Valle J,Minguillon J,Mercadal B,Becerra-Fajardo L,Navarro X,Ivorra A

    更新日期:2020-08-25 00:00:00

  • Comparing user-dependent and user-independent training of CNN for SSVEP BCI.

    abstract:OBJECTIVE:We presented a comparative study on the training methodologies of a convolutional neural network (CNN) for the detection of steady-state visually evoked potentials (SSVEP). Two training scenarios were also compared: user-independent (UI) training and user-dependent (UD) training. APPROACH:The CNN was trained...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Ravi A,Beni NH,Manuel J,Jiang N

    更新日期:2020-04-08 00:00:00

  • Ten-dimensional anthropomorphic arm control in a human brain-machine interface: difficulties, solutions, and limitations.

    abstract:OBJECTIVE:In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with tetraplegia using a brain-machine interface (BMI). The current study, in the same subject, immediately followed the previous work...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Wodlinger B,Downey JE,Tyler-Kabara EC,Schwartz AB,Boninger ML,Collinger JL

    更新日期:2015-02-01 00:00:00

  • On robust parameter estimation in brain-computer interfacing.

    abstract:OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Samek W,Nakajima S,Kawanabe M,Müller KR

    更新日期:2017-12-01 00:00:00

  • The impact of calcium current reversal on neurotransmitter release in the electrically stimulated retina.

    abstract:OBJECTIVE:In spite of intense theoretical and experimental investigations on electrical nerve stimulation, the influence of reversed ion currents on network activity during extracellular stimulation has not been investigated so far. APPROACH:Here, the impact of calcium current reversal on neurotransmitter release duri...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Werginz P,Rattay F

    更新日期:2016-08-01 00:00:00

  • An improved P300 pattern in BCI to catch user's attention.

    abstract:OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Jin J,Zhang H,Daly I,Wang X,Cichocki A

    更新日期:2017-06-01 00:00:00

  • A framework for designing data-driven optimization systems for neural modulation.

    abstract:OBJECTIVE:Neural modulation is a fundamental tool for understanding and treating neurological and psychiatric diseases. However, due to the high-dimensional space, subject-specific responses, and variability within each subject, it is a major challenge to select the stimulation parameters that have the desired effect. ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Connolly MJ,Park SE,Laxpati NG,Zaidi SA,Ghetiya M,Fernandez A,Gutekunst CA,Gross RE

    更新日期:2020-12-03 00:00:00

  • A neurorobotic platform for locomotor prosthetic development in rats and mice.

    abstract:OBJECTIVES:We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. APPROACH:We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules e...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: von Zitzewitz J,Asboth L,Fumeaux N,Hasse A,Baud L,Vallery H,Courtine G

    更新日期:2016-04-01 00:00:00

  • Selective recovery of fascicular activity in peripheral nerves.

    abstract::The peripheral nerves of an amputee's residual limb still carry the information required to provide the robust, natural control signals needed to command a dexterous prosthetic limb. However, these signals are mixed in the volume conductor of the body and extracting them is an unmet challenge. A beamforming algorithm ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Wodlinger B,Durand DM

    更新日期:2011-10-01 00:00:00

  • Exploring non-stationarity patterns in schizophrenia: neural reorganization abnormalities in the alpha band.

    abstract:OBJECTIVE:The aim of this paper was to characterize brain non-stationarity during an auditory oddball task in schizophrenia (SCH). The level of non-stationarity was measured in the baseline and response windows of relevant tones in SCH patients and healthy controls. APPROACH:Event-related potentials were recorded from...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Núñez P,Poza J,Bachiller A,Gomez-Pilar J,Lubeiro A,Molina V,Hornero R

    更新日期:2017-08-01 00:00:00

  • Probabilistic co-adaptive brain-computer interfacing.

    abstract:OBJECTIVE:Brain-computer interfaces (BCIs) are confronted with two fundamental challenges: (a) the uncertainty associated with decoding noisy brain signals, and (b) the need for co-adaptation between the brain and the interface so as to cooperatively achieve a common goal in a task. We seek to mitigate these challenges...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Bryan MJ,Martin SA,Cheung W,Rao RP

    更新日期:2013-12-01 00:00:00

  • Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord.

    abstract:OBJECTIVE:We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Capogrosso M,Gandar J,Greiner N,Moraud EM,Wenger N,Shkorbatova P,Musienko P,Minev I,Lacour S,Courtine G

    更新日期:2018-04-01 00:00:00

  • The spatial and temporal characteristics of the apparent-diffusion-coefficient-dependent fMRI signal changes during visual stimulation.

    abstract::The blood oxygenation level dependent (BOLD) contrast has been commonly used to detect fMRI signal. The majority of the BOLD signals are believed to arise from the venous and capillary networks. However, only those from the capillaries are spatially close to the neuronal activities, while the signals from large veins ...

    journal_title:Journal of neural engineering

    pub_type: 临床试验,杂志文章


    authors: Song AW,Gangstead SL

    更新日期:2004-03-01 00:00:00

  • Applying dynamic data collection to improve dry electrode system performance for a P300-based brain-computer interface.

    abstract:OBJECTIVE:Dry electrodes have an advantage over gel-based 'wet' electrodes by providing quicker set-up time for electroencephalography recording; however, the potentially poorer contact can result in noisier recordings. We examine the impact that this may have on brain-computer interface communication and potential app...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Clements JM,Sellers EW,Ryan DB,Caves K,Collins LM,Throckmorton CS

    更新日期:2016-12-01 00:00:00

  • Laboratory investigation of microelectronics-based stimulators for large-scale suprachoroidal transretinal stimulation (STS).

    abstract::This paper describes the technological developments underlying the realization of a reliable and reproducible microchip-based stimulator with a large number of stimulus electrodes. A microchip-based stimulator with over 500 electrodes for suprachoroidal transretinal stimulation (STS) is proposed in this paper, and an ...

    journal_title:Journal of neural engineering

    pub_type: 杂志文章


    authors: Ohta J,Tokuda T,Kagawa K,Sugitani S,Taniyama M,Uehara A,Terasawa Y,Nakauchi K,Fujikado T,Tano Y

    更新日期:2007-03-01 00:00:00