Abstract:
OBJECTIVES:We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. APPROACH:We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules exhibiting selective compliance along distinct directions. This combination allowed high-precision force and torque control in multiple directions over a large workspace. We next designed a neurorobotic platform wherein real-time kinematics and physiological signals directly adjust robotic actuation and prosthetic actions. We tested the performance of this platform in both rats and mice with spinal cord injury. MAIN RESULTS:Kinematic analyses showed that the robotic interface did not impede locomotor movements of lightweight mice that walked freely along paths with changing directions and height profiles. Personalized trunk assistance instantly enabled coordinated locomotion in mice and rats with severe hindlimb motor deficits. Closed-loop control of robotic actuation based on ongoing movement features enabled real-time control of electromyographic activity in anti-gravity muscles during locomotion. SIGNIFICANCE:This neurorobotic platform will support the study of the mechanisms underlying the therapeutic effects of locomotor prosthetics and rehabilitation using high-resolution genetic tools in rodent models.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
von Zitzewitz J,Asboth L,Fumeaux N,Hasse A,Baud L,Vallery H,Courtine Gdoi
10.1088/1741-2560/13/2/026007subject
Has Abstractpub_date
2016-04-01 00:00:00pages
026007issue
2eissn
1741-2560issn
1741-2552journal_volume
13pub_type
杂志文章abstract::The aim of this study was to assess the accuracy of the convolution kernel compensation (CKC) method in decomposing high-density surface EMG (HDsEMG) signals from the pennate biceps femoris long-head muscle. Although the CKC method has already been thoroughly assessed in parallel-fibered muscles, there are several fac...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/8/6/066002
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:We have recently developed a prototype of a novel human-computer interface for assistive communication based on voluntary shifts of attention (gaze) from a far target to a near target associated with a decrease of pupil size (Pupillary Accommodative Response, PAR), an automatic vegetative response that can be...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab8e8f
更新日期:2020-04-29 00:00:00
abstract:OBJECTIVE:Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. APPROACH:Multi-contact cuff electrode...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/2/026002
更新日期:2015-04-01 00:00:00
abstract::Some issues in neuroscience can be addressed by building robot models of biological sensorimotor systems. What we can conclude from building models or simulations, however, is determined by a number of factors in addition to the central hypothesis we intend to test. These include the way in which the hypothesis is rep...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/3/3/R01
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:Rhythmic brain stimulation has emerged as a powerful tool to modulate cognition and to target pathological oscillations related to neurological and psychiatric disorders. However, we lack a systematic understanding of how periodic stimulation interacts with endogenous neural activity as a function of the brai...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaeb03
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:We consider the problem of optimal probing to learn connections in an evoked dynamic network. Such a network, in which each edge measures an input-output relationship between sites in sensor/actuator-space, is relevant to emerging applications in neural mapping and neural connectivity estimation. APPROACH:We...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/6/066011
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:A major difficulty of brain-computer interface (BCI) technology is dealing with the noise of EEG and its signal variations. Previous works studied time-dependent non-stationarities for BCIs in which the user's mental task was independent of the device operation (e.g., the mental task was motor imagery and the...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/2/026024
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Despite the high number of degrees of freedom of the human hand, most actions of daily life can be executed incorporating only palmar, pincer and lateral grasp. In this study we attempt to discriminate these three different executed reach-and-grasp actions utilizing their EEG neural correlates. APPROACH:In a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa8911
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:This paper discusses the invariance and variability in interaction error-related potentials (ErrPs), where a special focus is laid upon the factors of (1) the human mental processing required to assess interface actions (2) time (3) subjects. APPROACH:Three different experiments were designed as to vary prim...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa8416
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:There has recently been an increasing interest in local field potential (LFP) for brain-machine interface (BMI) applications due to its desirable properties (signal stability and low bandwidth). LFP is typically recorded with respect to a single unipolar reference which is susceptible to common noise. Several...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abce3c
更新日期:2020-11-26 00:00:00
abstract::Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/3/003
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:The goal of this study is to characterize the phenomenon of evoked tactile sensation (ETS) on the stump skin of forearm amputees using transcutaneous electrical nerve stimulation (TENS). APPROACH:We identified the projected finger map (PFM) of ETS on the stump skin in 11 forearm amputees, and compared percep...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/12/6/066002
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Differential measurement of efferent and afferent peripheral nerve activity offers a promising means of improving the clinical utility of implantable neuroprostheses. The tripolar nerve cuff electrode has historically served as the gold standard for achieving high signal-to-noise ratios (SNRs) of the recordin...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6407
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Currently, there are some 95 000 people in Europe suffering from upper-limb impairment. Rehabilitation should be undertaken right after the impairment occurs and should be regularly performed thereafter. Moreover, the rehabilitation process should be tailored specifically to both patient and impairment. APPR...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaf35f
更新日期:2019-04-01 00:00:00
abstract::We present a micromachined 252-channel ECoG (electrocorticogram)-electrode array, which is made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths. The array subtends an area of approximately 35 mm by 60 mm and is designed to cover large parts of a hemisphere of a macaq...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/6/3/036003
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:The past two decades have seen dramatic progress in our ability to model brain signals recorded by electroencephalography, functional near-infrared spectroscopy, etc., and to derive real-time estimates of user cognitive state, response, or intent for a variety of purposes: to restore communication by the seve...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/10/5/056014
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:High-fidelity vibrokinetic (HFVK) technology is widely used to enhance the immersiveness of audiovisual (AV) entertainment experiences. However, despite evidence that HFVK technology does subjectively enhance AV immersion, the underlying mechanism has not been clarified. Neurophysiological studies could provi...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abaca2
更新日期:2020-09-26 00:00:00
abstract::Electrical stimulation of peripheral nerve activates large-diameter fibers before small ones. A physiological recruitment order, from small to large-diameter axons, is desirable in many applications. Previous studies using computer simulations showed that selective activation of small fibers could be achieved by resha...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/1/4/003
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Depression is a severe mental disorder. However, the neural mechanisms underlying affective interference (difficulties in directing attention away from negative distractors) in depression patients are still not well-understood. In particular, the connections between brain regions remain unclear. Using the emo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aacdbb
更新日期:2018-10-01 00:00:00
abstract::The objective of this work is to develop and test a photovoltaic retinal prosthesis for restoring sight to patients blinded by degenerative retinal diseases. A silicon photodiode array for subretinal stimulation has been fabricated by a silicon-integrated-circuit/MEMS process. Each pixel in the two-dimensional array c...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/9/4/046014
更新日期:2012-08-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aae8d9
更新日期:2019-02-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/14/1/016004
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces. APPROACH:We evaluated the chronic reliability of novel 61-channel micro-electrocorticographic (µECoG) arrays in rats chronically implanted for over one year and usi...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aae39d
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Currently commercially available nerve conduits have demonstrated suboptimal clinical efficacy in repairing peripheral nerve defects. Although tissue-engineered nerve grafts (TENGs) with sustained release of neurotrophic factors (NTFs) are experimentally proved to be more effective than these blank conduits, ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abd1ec
更新日期:2020-12-09 00:00:00
abstract::Glutamate spillover is thought to play a significant role in increasing neural transmission at the mossy fiber/granule cell cerebellar glomerulus. Glutamate spillover has been shown to activate AMPA receptors at the glomerulus, and here we complete the characterization of spillover at the glomerulus by investigating t...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2560/4/3/013
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Intracortical brain-machine interfaces (iBMIs) aim to restore efficient communication and movement ability for paralyzed patients. However, frequent recalibration is required for consistency and reliability, and every recalibration will require relatively large most current sample set. The aim in this study i...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aaa8a4
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa6213
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Cochlear implants, while providing significant benefits to recipients, remain limited due to broad neural activation. Focussed multipolar stimulation (FMP) is an advanced stimulation strategy that uses multiple current sources to produce highly focussed patterns of neural excitation in order to overcome these...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aad0a5
更新日期:2018-10-01 00:00:00
abstract::Human trials of prototype visual prostheses have successfully elicited visual percepts (phosphenes) in the visual field of implant recipients blinded through retinitis pigmentosa and age-related macular degeneration. Researchers are progressing rapidly towards a device that utilizes individual phosphenes as the elemen...
journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2560/6/3/035009
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Currently commercially available nerve conduits have demonstrated suboptimal clinical efficacy in repairing peripheral nerve defects. Although tissue-engineered nerve grafts (TENGs) with sustained release of neurotrophic factors (NTFs) are experimentally proved to be more effective than these blank conduits, ...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/ab17a0
更新日期:2019-06-01 00:00:00