Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model.

Abstract:

:Neural activity can be modulated by applying a polarizing low-frequency (<100 Hz) electric field (PLEF). Unlike conventional pulsed stimulation, PLEF stimulation has a graded, modulatory effect on neuronal excitability, and permits the simultaneous recording of neuronal activity during stimulation suitable for continuous feedback control. We tested a prototype system that allows for simultaneous PLEF stimulation with minimal recording artifact in a chronic tetanus toxin animal model (rat) of hippocampal epilepsy with spontaneous seizures. Depth electrode local field potentials recorded during seizures revealed a characteristic pattern of field postsynaptic potentials (fPSPs). Sinusoidal voltage-controlled PLEF stimulation (0.5-25 Hz) was applied in open-loop cycles radially across the CA3 of ventral hippocampus. For stimulated seizures, fPSPs were transiently entrained with the PLEF waveform. Statistical significance of entrainment was assessed with Thomson's harmonic F-test, with 45/132 stimulated seizures in four animals individually demonstrating significant entrainment (p < 0.04). Significant entrainment for multiple presentations at the same frequency (p < 0.01) was observed in three of four animals in 42/64 stimulated seizures. This is the first demonstration in chronically implanted freely behaving animals of PLEF modulation of neural activity with simultaneous recording.

journal_name

J Neural Eng

authors

Sunderam S,Chernyy N,Peixoto N,Mason JP,Weinstein SL,Schiff SJ,Gluckman BJ

doi

10.1088/1741-2560/6/4/046009

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

046009

issue

4

eissn

1741-2560

issn

1741-2552

pii

S1741-2560(09)07611-3

journal_volume

6

pub_type

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