Abstract：
OBJECTIVE:Current mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale domains have a role in seizure generation that may be clinically significant. We use high-resolution, active, flexible surface electrode arrays with 500 μm inter-electrode spacing to explore epileptiform local field potential (LFP) spike propagation patterns in two dimensions recorded from subdural micro-electrocorticographic signals in vivo in cat. In this study, we aimed to develop methods to quantitatively characterize the spatiotemporal dynamics of epileptiform activity at high-resolution. APPROACH:We topically administered a GABA-antagonist, picrotoxin, to induce acute neocortical epileptiform activity leading up to discrete electrographic seizures. We extracted features from LFP spikes to characterize spatiotemporal patterns in these events. We then tested the hypothesis that two-dimensional spike patterns during seizures were different from those between seizures. MAIN RESULTS:We showed that spatially correlated events can be used to distinguish ictal versus interictal spikes. SIGNIFICANCE:We conclude that sub-millimeter-scale spatiotemporal spike patterns reveal network dynamics that are invisible to standard clinical recordings and contain information related to seizure-state.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Vanleer AC,Blanco JA,Wagenaar JB,Viventi J,Contreras D,Litt Bdoi
10.1088/1741-2560/13/2/026015subject
Has Abstractpub_date
2016-04-01 00:00:00pages
026015issue
2eissn
1741-2560issn
1741-2552journal_volume
13pub_type
杂志文章abstract：OBJECTIVE:Bladder dysfunction is a significant and largely unaddressed problem for people living with spinal cord injury. Intermittent catheterization does not provide volitional control of micturition and has numerous side effects. Targeted electrical microstimulation of the spinal cord has been previously explored fo...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/abca13
更新日期：2020-11-12 00:00:00
abstract：:The gait outcome measures used in clinical trials of paraplegic locomotor training determine the effectiveness of improved walking function assisted by the functional electrical stimulation (FES) system. Focused on kinematic, kinetic or physiological changes of paraplegic patients, traditional methods cannot quantify ...
journal_title：Journal of neural engineering
pub_type： 临床试验,杂志文章
doi：10.1088/1741-2560/6/6/066007
更新日期：2009-12-01 00:00:00
abstract：:We present the results of a 5-year patient follow-up after implantation of an original neuroprosthesis. The system is able to stimulate both epimysial and neural electrodes in such a way that the complete flexor-extensor chain of the lower limb can be activated without using the withdrawal reflex. We demonstrate that ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/3/4/003
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:The goal of this study is to characterize the phenomenon of evoked tactile sensation (ETS) on the stump skin of forearm amputees using transcutaneous electrical nerve stimulation (TENS). APPROACH:We identified the projected finger map (PFM) of ETS on the stump skin in 11 forearm amputees, and compared percep...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/12/6/066002
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:Most brain-computer interfaces (BCIs) based on functional near-infrared spectroscopy (fNIRS) require that users perform mental tasks such as motor imagery, mental arithmetic, or music imagery to convey a message or to answer simple yes or no questions. These cognitive tasks usually have no direct association ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aae4b9
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:Due to their increased proximity to retinal ganglion cells (RGCs), epiretinal visual prostheses present the opportunity for eliciting phosphenes with low thresholds through direct RGC activation. This study characterised the in vivo performance of a novel prototype monolithic epiretinal prosthesis, containing...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aba560
更新日期：2020-08-05 00:00:00
abstract：OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa6213
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:Over the past two decades retinal prostheses have made major strides in restoring functional vision to patients blinded by diseases such as retinitis pigmentosa. Presently, implants use single pulses to activate the retina. Though this stimulation paradigm has proved beneficial to patients, an unresolved prob...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa722c
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:State of the art brain-computer interface (BCI) research focuses on improving individual components such as the application or the decoder that converts the user's brain activity to control signals. In this study, we investigate the interaction between these components in the P300 speller, a BCI for communica...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/12/6/066027
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:High-rate pulse trains have proven to be effective in cochlear prosthetics and, more recently, have been shown to elicit a wide range of interesting response properties in axons of the peripheral nervous system. Surprisingly, the effectiveness of such trains for use in retinal prostheses has not been explored...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/10/3/036009
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:Spike detection from extracellular recordings is a crucial preprocessing step when analyzing neuronal activity. The decision whether a specific part of the signal is a spike or not is important for any kind of other subsequent preprocessing steps, like spike sorting or burst detection in order to reduce the c...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa654b
更新日期：2017-06-01 00:00:00
abstract：:This review paper shows that tungsten should not generally be used as a chronically implanted material. The metal has a long implant history, from neuroscience, vascular medicine, radiography, orthopaedics, prosthodontics, and various other fields, primarily as a result of its high density, radiopacity, tensile streng...
journal_title：Journal of neural engineering
pub_type： 杂志文章,评审
doi：10.1088/1741-2552/aaa502
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:Ultrasounds (US) use in neural engineering is so far mainly limited to ablation through high intensity focused ultrasound, but interesting preliminary results show that low intensity low frequency ultrasound could be used instead to modulate neural activity. However, the extent of this modulatory ability of U...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/abae8b
更新日期：2020-10-14 00:00:00
abstract：:We introduce algorithms and architectures for automatic spike detection and alignment that are designed for low power. Some of the algorithms are based on principal component analysis (PCA). Others employ a novel integral transform analysis and achieve 99% of the precision of a PCA detector, while requiring only 0.05%...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/3/1/004
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:The objective of this work is to use the capability of spiking neural networks to capture the spatio-temporal information encoded in time-series signals and decode them without the use of hand-crafted features and vector-based learning and the realization of the spiking model on low-power neuromorphic hardwar...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aafabc
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:Haptic feedback is crucial when we manipulate objects. Information pertaining to an object's stiffness in particular can help facilitate fine motor control. In this study, we seek to determine whether objects of different stiffness levels can be recognized using haptic feedback provided by transcutaneous elec...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab4d99
更新日期：2019-12-05 00:00:00
abstract：:The extraction of distinctly separable features from electroencephalogram (EEG) is one of the main challenges in designing a brain-computer interface (BCI). Existing feature extraction techniques for a BCI are mostly developed based on traditional signal processing techniques assuming that the signal is Gaussian and h...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/8/2/025014
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:Electroencephalography (EEG) offers a unique opportunity to study human neural activity non-invasively with millisecond resolution using minimal equipment in or outside of a lab setting. EEG can be combined with a number of techniques for closed-loop experiments, where external devices are driven by specific ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa651f
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:Microwire and Utah-style neural recording arrays are the predominant devices used for cortical neural recording, but the implanted electrodes cause a significant adverse biological response and suffer from well-studied performance degradation. Recent work has demonstrated that carbon fiber electrodes do not e...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aae8d9
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:While motor-imagery based brain-computer interfaces (BCIs) have been studied over many years by now, most of these studies have taken place in controlled lab settings. Bringing BCI technology into everyday life is still one of the main challenges in this field of research. APPROACH:This paper systematically ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/13/5/056012
更新日期：2016-10-01 00:00:00
abstract：:We consider the problem of desynchronizing a network of synchronized, globally (all-to-all) coupled neurons using an input to a single neuron. This is done by applying the discrete time dynamic programming method to reduced phase models for neural populations. This technique numerically minimizes a certain cost functi...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/8/6/065008
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:Electroencephalography (EEG) recorded during transcranial alternating current simulation (tACS) is highly desirable in order to investigate brain dynamics during stimulation, but is corrupted by large amplitude stimulation artefacts. Artefact removal algorithms have been presented previously, but with substan...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab58a3
更新日期：2020-01-24 00:00:00
abstract：OBJECTIVE:Neural reflexes regulate immune responses and homeostasis. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus n...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa7a42
更新日期：2017-12-01 00:00:00
abstract：:We present a micromachined 252-channel ECoG (electrocorticogram)-electrode array, which is made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths. The array subtends an area of approximately 35 mm by 60 mm and is designed to cover large parts of a hemisphere of a macaq...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/6/3/036003
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:In biomagnetic signal processing, the theory of the signal subspace has been applied to removing interfering magnetic fields, and a representative algorithm is the signal space projection algorithm, in which the signal/interference subspace is defined in the spatial domain as the span of signal/interference-s...
journal_title：Journal of neural engineering
pub_type： 杂志文章,评审
doi：10.1088/1741-2552/aa7693
更新日期：2017-10-01 00:00:00
abstract：:We describe a brain-computer interface for controlling a humanoid robot directly using brain signals obtained non-invasively from the scalp through electroencephalography (EEG). EEG has previously been used for tasks such as controlling a cursor and spelling a word, but it has been regarded as an unlikely candidate fo...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/5/2/012
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits. APPROACH:This progress was enabled by the team-based, inte...
journal_title：Journal of neural engineering
pub_type： 杂志文章,评审
doi：10.1088/1741-2552/ab4869
更新日期：2019-11-12 00:00:00
abstract：OBJECTIVE:The rapidly developing paradigm of closed-loop neuroscience has extensively employed brain rhythms as the signal forming real-time neurofeedback, triggering brain stimulation, or governing stimulus selection. However, the efficacy of brain rhythm contingent paradigms suffers from significant delays related to...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab890f
更新日期：2020-08-04 00:00:00
abstract：OBJECTIVE:Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease and dystonia improves motor symptoms and quality of life. Traditionally, pallidal borders have been demarcated by electrophysiological microelectrode recordings (MERs) during DBS surgery. How...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab53ac
更新日期：2020-01-06 00:00:00
abstract：:A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation a...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/9/3/036009
更新日期：2012-06-01 00:00:00
