Abstract：
:Hybrid electro-optical neural stimulation is a novel paradigm combining the advantages of optical and electrical stimulation techniques while reducing their respective limitations. However, in order to fulfill its promise, this technique requires reduced variability and improved reproducibility. Here we used a comparative physiological approach to aid the further development of this technique by identifying the spatial and temporal factors characteristic of hybrid stimulation that may contribute to experimental variability and/or a lack of reproducibility. Using transient pulses of infrared light delivered simultaneously with a bipolar electrical stimulus in either the marine mollusk Aplysia californica buccal nerve or the rat sciatic nerve, we determined the existence of a finite region of excitability with size altered by the strength of the optical stimulus and recruitment dictated by the polarity of the electrical stimulus. Hybrid stimulation radiant exposures yielding 50% probability of firing (RE₅₀) were shown to be negatively correlated with the underlying changes in electrical stimulation threshold over time. In Aplysia, but not in the rat sciatic nerve, increasing optical radiant exposures (J cm⁻²) beyond the RE₅₀ ultimately resulted in inhibition of evoked potentials. Accounting for the sources of variability identified in this study increased the reproducibility of stimulation from 35% to 93% in Aplysia and 23% to 76% in the rat with reduced variability.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Duke AR,Lu H,Jenkins MW,Chiel HJ,Jansen EDdoi
10.1088/1741-2560/9/3/036003subject
Has Abstractpub_date
2012-06-01 00:00:00pages
036003issue
3eissn
1741-2560issn
1741-2552journal_volume
9pub_type
杂志文章abstract：OBJECTIVE:We implemented computational models of human and rat cortical neurons for simulating the neural response to cortical stimulation with electromagnetic fields. APPROACH:We adapted model neurons from the library of Blue Brain models to reflect biophysical and geometric properties of both adult rat and human cor...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aadbb1
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:It is known that multi-site interleaved stimulation generates less muscle fatigue compared to single-site synchronous stimulation. However, in the limited number of studies in which intramuscular electrodes were used, the fatigue reduction associated with interleaved stimulation could not consistently be achi...
journal_title：Journal of neural engineering
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更新日期：2020-08-25 00:00:00
abstract：OBJECTIVE:The generalization and robustness of an electroencephalogram (EEG)-based system are crucial requirements in actual practices. APPROACH:To reach these goals, we propose a new EEG representation that provides a more realistic view of brain functionality by applying multi-instance (MI) framework to consider the...
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更新日期：2015-04-01 00:00:00
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journal_title：Journal of neural engineering
pub_type： 杂志文章,评审
doi：10.1088/1741-2552/aa6cbb
更新日期：2017-08-01 00:00:00
abstract：:Neural activity can be modulated by applying a polarizing low-frequency (<100 Hz) electric field (PLEF). Unlike conventional pulsed stimulation, PLEF stimulation has a graded, modulatory effect on neuronal excitability, and permits the simultaneous recording of neuronal activity during stimulation suitable for continu...
journal_title：Journal of neural engineering
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/4/3/003
更新日期：2007-09-01 00:00:00
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journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/3/4/003
更新日期：2006-12-01 00:00:00
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更新日期：2019-10-29 00:00:00
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更新日期：2008-09-01 00:00:00
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
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更新日期：2013-10-01 00:00:00
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更新日期：2020-11-26 00:00:00
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pub_type： 杂志文章
doi：10.1088/1741-2560/12/4/046021
更新日期：2015-08-01 00:00:00
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更新日期：2020-01-31 00:00:00
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更新日期：2012-08-01 00:00:00
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更新日期：2011-04-01 00:00:00
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更新日期：2020-06-12 00:00:00
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更新日期：2009-12-01 00:00:00
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更新日期：2020-08-04 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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更新日期：2013-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
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更新日期：2012-10-01 00:00:00
