An implantable neuroprosthesis for standing and walking in paraplegia: 5-year patient follow-up.

abstract：OBJECTIVE:Loss of even part of the upper limb is a devastating injury. In order to fully restore natural function when lacking sufficient residual musculature, it is necessary to record directly from peripheral nerves. However, current approaches must make trade-offs between signal quality and longevity which limit the...

journal_title：Journal of neural engineering

authors： Irwin ZT,Schroeder KE,Vu PP,Tat DM,Bullard AJ,Woo SL,Sando IC,Urbanchek MG,Cederna PS,Chestek CA

更新日期：2016-08-01 00:00:00

abstract：:Retinal implants have proven their ability to restore visual sensation to people with degenerative retinopathy, characterized by photoreceptor cell death and the retina's inability to sense light. Retinal bionics operate by electrically stimulating the surviving neurons in the retina, thus triggering the transfer of v...

journal_title：Journal of neural engineering

authors： Bareket L,Barriga-Rivera A,Zapf MP,Lovell NH,Suaning GJ

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technolog...

journal_title：Journal of neural engineering

authors： Shepherd RK,Villalobos J,Burns O,Nayagam DAX

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Implantable brain-computer interface (BCI) research promises improvements in human health and enhancements in quality of life. Informed consent of subjects is a central tenet of this research. Rapid advances in neuroscience, and the intimate connection between functioning of the brain and conceptions of the s...

journal_title：Journal of neural engineering

authors： Klein E,Ojemann J

更新日期：2016-08-01 00:00:00

abstract：:We consider the problem of desynchronizing a network of synchronized, globally (all-to-all) coupled neurons using an input to a single neuron. This is done by applying the discrete time dynamic programming method to reduced phase models for neural populations. This technique numerically minimizes a certain cost functi...

journal_title：Journal of neural engineering

authors： Nabi A,Moehlis J

更新日期：2011-12-01 00:00:00

abstract：:A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation a...

journal_title：Journal of neural engineering

authors： Cicione R,Shivdasani MN,Fallon JB,Luu CD,Allen PJ,Rathbone GD,Shepherd RK,Williams CE

更新日期：2012-06-01 00:00:00

abstract：UNLABELLED:Transcranial Doppler (TCD) was recently introduced as a new brain-computer interface (BCI) modality for detecting task-induced hemispheric lateralization. To date, single-trial discrimination between a lateralized mental activity and a rest state has been demonstrated with long (45 s) activation time periods...

journal_title：Journal of neural engineering

authors： Aleem I,Chau T

更新日期：2013-02-01 00:00:00

abstract：:All of the human prosthetic visual systems implanted so far have been achromatic. Schmidt et al. (1996) reported that at low stimulation intensities their subject reported that phosphenes usually had a specific hue, but when the stimulus intensity was increased, they desaturated to white. We speculate here that previo...

journal_title：Journal of neural engineering

authors： Towle V,Pham T,McCaffrey M,Allen D,Troyk PR

更新日期：2020-12-18 00:00:00

abstract：OBJECTIVE:Spike detection from extracellular recordings is a crucial preprocessing step when analyzing neuronal activity. The decision whether a specific part of the signal is a spike or not is important for any kind of other subsequent preprocessing steps, like spike sorting or burst detection in order to reduce the c...

journal_title：Journal of neural engineering

authors： Lieb F,Stark HG,Thielemann C

更新日期：2017-06-01 00:00:00

abstract：:Chronic motor cortex stimulation (MCS) is currently being investigated as a treatment method for Parkinson's disease (PD). Unfortunately, the underlying mechanisms of this treatment are unclear and there are many uncertainties regarding the most effective stimulation parameters and electrode configuration. In this pap...

journal_title：Journal of neural engineering

authors： Zwartjes DG,Heida T,Feirabend HK,Janssen ML,Visser-Vandewalle V,Martens HC,Veltink PH

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the benefit of integrating thermal imaging into an artificial vision therapy system, the Argus II retinal prosthesis, in simplifying a complex scene and improving mobility performance in the presence of other persons. APPROACH:Four Argus II retinal implant users were evaluated on two tasks: to lo...

journal_title：Journal of neural engineering

authors： He Y,Sun SY,Roy A,Caspi A,Montezuma SR

更新日期：2020-08-04 00:00:00

abstract：OBJECTIVE:The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces. APPROACH:We evaluated the chronic reliability of novel 61-channel micro-electrocorticographic (µECoG) arrays in rats chronically implanted for over one year and usi...

journal_title：Journal of neural engineering

authors： Woods V,Trumpis M,Bent B,Palopoli-Trojani K,Chiang CH,Wang C,Yu C,Insanally MN,Froemke RC,Viventi J

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. AP...

journal_title：Journal of neural engineering

authors： Barragan A,Preston C,Alvarez A,Bera T,Qin Y,Weinand M,Kasoff W,Witte RS

更新日期：2020-10-30 00:00:00

abstract：OBJECTIVE:Schwann cells (SCs) are primary structural and functional cells in the peripheral nervous system. These cells play a crucial role in peripheral nerve regeneration by releasing neurotrophic factors. This study evaluated the neural differentiation potential effects of stem cells from human exfoliated deciduous ...

journal_title：Journal of neural engineering

authors： Su WT,Pan YJ

更新日期：2016-08-01 00:00:00

abstract：:We describe a brain-computer interface for controlling a humanoid robot directly using brain signals obtained non-invasively from the scalp through electroencephalography (EEG). EEG has previously been used for tasks such as controlling a cursor and spelling a word, but it has been regarded as an unlikely candidate fo...

journal_title：Journal of neural engineering

authors： Bell CJ,Shenoy P,Chalodhorn R,Rao RP

更新日期：2008-06-01 00:00:00

abstract：:In this work the application of different machine learning techniques for classification of mental tasks from electroencephalograph (EEG) signals is investigated. The main application for this research is the improvement of brain computer interface (BCI) systems. For this purpose, Bayesian graphical network, neural ne...

journal_title：Journal of neural engineering

authors： Rezaei S,Tavakolian K,Nasrabadi AM,Setarehdan SK

更新日期：2006-06-01 00:00:00

abstract：:In this paper, we investigate the influence of hypercapnia on the dynamics of the phrenic neurogram in the piglet in two different age groups: 3-7 days (n = 11) and 10-16 days (n = 9). The phrenic neurogram was recorded from 17 piglets (3-16 days old) during control (40% O(2) with 3-5% end-tidal CO(2)), mild hypercapn...

journal_title：Journal of neural engineering

authors： Akay M

更新日期：2005-06-01 00:00:00

abstract：:We investigated the relationships of the firing rate and maximal recruitment threshold of motoneurons recorded during isometric contraction with the number of spindles in individual muscles. At force levels above 10% of maximal voluntary contraction, the firing rate was inversely related to the number of spindles in a...

journal_title：Journal of neural engineering

authors： De Luca CJ,Kline JC

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Brain-computer interfaces (BCI) are becoming important tools for assistive technology, particularly through the use of motor imagery (MI) for aiding task completion. However, most existing methods of MI classification have been applied in a trial-wise fashion, with window sizes of approximately 2 s or more. A...

journal_title：Journal of neural engineering

authors： Freer D,Yang GZ

更新日期：2020-01-31 00:00:00

abstract：OBJECTIVE:Brains, like other physical devices, are inherently noisy. This source of variability is large, to the extent that internal noise often impacts human sensory processing more than externally induced (stimulus-driven) perturbations. Despite the fundamental nature of this phenomenon, its statistical distribution...

journal_title：Journal of neural engineering

authors： Neri P

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Activity-dependent stimulation (ADS) is designed to strengthen the connections between neuronal circuits and therefore may be a promising tool for promoting neurophysiological reorganization following a brain injury. To successfully perform this technique, two criteria must be met: (1) spikes in the extracell...

journal_title：Journal of neural engineering

authors： Murphy M,Buccelli S,Bornat Y,Bundy D,Nudo R,Guggenmos D,Chiappalone M

更新日期：2019-10-29 00:00:00

abstract：OBJECTIVE:When designing multiclass motor imagery-based brain-computer interface (MI-BCI), a so-called tangent space mapping (TSM) method utilizing the geometric structure of covariance matrices is an effective technique. This paper aims to introduce a method using TSM for finding accurate operational frequency bands r...

journal_title：Journal of neural engineering

authors： Islam MR,Tanaka T,Molla MKI

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Stability and selectivity are important when restoring long-term, functional sensory feedback in individuals with limb-loss. Our objective is to demonstrate a chronic, clinical neural stimulation system for providing selective sensory response in two upper-limb amputees. APPROACH:Multi-contact cuff electrode...

journal_title：Journal of neural engineering

authors： Tan DW,Schiefer MA,Keith MW,Anderson JR,Tyler DJ

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:It is known that multi-site interleaved stimulation generates less muscle fatigue compared to single-site synchronous stimulation. However, in the limited number of studies in which intramuscular electrodes were used, the fatigue reduction associated with interleaved stimulation could not consistently be achi...

journal_title：Journal of neural engineering

authors： Eladly A,Del Valle J,Minguillon J,Mercadal B,Becerra-Fajardo L,Navarro X,Ivorra A

更新日期：2020-08-25 00:00:00

abstract：:Corrosion is a prime concern for active implantable devices. In this paper we review the principles underlying the concepts of hermetic packages and encapsulation, used to protect implanted electronics, some of which remain widely overlooked. We discuss how technological advances have created a need to update the way ...

journal_title：Journal of neural engineering

authors： Vanhoestenberghe A,Donaldson N

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Electroencephalography (EEG) offers a unique opportunity to study human neural activity non-invasively with millisecond resolution using minimal equipment in or outside of a lab setting. EEG can be combined with a number of techniques for closed-loop experiments, where external devices are driven by specific ...

journal_title：Journal of neural engineering

authors： Black C,Voigts J,Agrawal U,Ladow M,Santoyo J,Moore C,Jones S

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Cochlear implants, while providing significant benefits to recipients, remain limited due to broad neural activation. Focussed multipolar stimulation (FMP) is an advanced stimulation strategy that uses multiple current sources to produce highly focussed patterns of neural excitation in order to overcome these...

journal_title：Journal of neural engineering

authors： Senn P,Shepherd RK,Fallon JB

更新日期：2018-10-01 00:00:00

abstract：:The peripheral nerves of an amputee's residual limb still carry the information required to provide the robust, natural control signals needed to command a dexterous prosthetic limb. However, these signals are mixed in the volume conductor of the body and extracting them is an unmet challenge. A beamforming algorithm ...

journal_title：Journal of neural engineering

authors： Wodlinger B,Durand DM

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Retinal prosthetic implants restore partial vision to patients blinded due to outer retinal degeneration, using a camera-guided multielectrode array (MEA) that electrically stimulates surviving retinal neurons. Commercial epi-retinal prostheses use millisecond-scale charge-balanced, symmetric, cathodic-first ...

journal_title：Journal of neural engineering

authors： Chang YC,Haji Ghaffari D,Chow RH,Weiland JD

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target s...

journal_title：Journal of neural engineering

authors： Jin J,Zhang H,Daly I,Wang X,Cichocki A

更新日期：2017-06-01 00:00:00