Informed consent in implantable BCI research: identification of research risks and recommendations for development of best practices.

abstract：:Extracellular metal microelectrodes are widely used to record single neuron activity in vivo. However, their signal-to-noise ratio (SNR) is often far from optimal due to their high impedance value. It has been recently reported that carbon nanotube (CNT) coatings may decrease microelectrode impedance, thus improving t...

journal_title：Journal of neural engineering

authors： Baranauskas G,Maggiolini E,Castagnola E,Ansaldo A,Mazzoni A,Angotzi GN,Vato A,Ricci D,Panzeri S,Fadiga L

更新日期：2011-12-01 00:00:00

abstract：:In the study of the spreading depression (SD) wave phenomenon and its dynamics, it is necessary to describe the ionic movements along the extracellular space, as well as between this and the intracellular space. In both cases, the ionic movement includes a double coupling involving the concentration and the potential ...

journal_title：Journal of neural engineering

authors： Teixeira HZ,de Almeida AC,Infantosi AF,Vasconcelos MA,Duarte MA

更新日期：2004-06-01 00:00:00

abstract：:Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a...

journal_title：Journal of neural engineering

authors： Sorensen ME,DeWeerth SP

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Neuromusculoskeletal models involve many subject-specific physiological parameters that need to be adjusted to adequately represent muscle properties. Traditionally, neuromusculoskeletal models have been calibrated with a forward-inverse dynamic optimization which is time-consuming and unfeasible for rehabili...

journal_title：Journal of neural engineering

authors： Bueno DR,Montano L

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Implantable retinal prostheses aim to provide artificial vision to those suffering from retinal degenerative diseases by electrically stimulating the remaining retinal neurons using a multi-electrode array. The spatial resolution of these devices can be improved by creation of so-called virtual channels (VCs)...

journal_title：Journal of neural engineering

authors： Song X,Guo T,Shivdasani MN,Dokos S,Lovell NH,Li X,Qiu S,Li T,Zheng S,Li L

更新日期：2020-10-21 00:00:00

abstract：OBJECTIVE:Microwire and Utah-style neural recording arrays are the predominant devices used for cortical neural recording, but the implanted electrodes cause a significant adverse biological response and suffer from well-studied performance degradation. Recent work has demonstrated that carbon fiber electrodes do not e...

journal_title：Journal of neural engineering

authors： Massey TL,Santacruz SR,Hou JF,Pister KSJ,Carmena JM,Maharbiz MM

更新日期：2019-02-01 00:00:00

abstract：:Significant progress has been made in systems that interpret the electrical signals of the brain in order to control an actuator. One version of these systems senses neuronal extracellular action potentials with an array of up to 100 miniature probes inserted into the cortex. The impedance of each probe is high, so en...

journal_title：Journal of neural engineering

authors： Jochum T,Denison T,Wolf P

更新日期：2009-02-01 00:00:00

abstract：:Implantable electrode arrays capable of recording and stimulating neural activity with high spatial and temporal resolution will provide a foundation for future brain computer interface technology. Currently, their clinical impact has been curtailed by a general lack of functional stability, which can be attributed to...

journal_title：Journal of neural engineering

authors： Retterer ST,Smith KL,Bjornsson CS,Turner JN,Isaacson MS,Shain W

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines ...

journal_title：Journal of neural engineering

authors： Capogrosso M,Gandar J,Greiner N,Moraud EM,Wenger N,Shkorbatova P,Musienko P,Minev I,Lacour S,Courtine G

更新日期：2018-04-01 00:00:00

abstract：:Chronic motor cortex stimulation (MCS) is currently being investigated as a treatment method for Parkinson's disease (PD). Unfortunately, the underlying mechanisms of this treatment are unclear and there are many uncertainties regarding the most effective stimulation parameters and electrode configuration. In this pap...

journal_title：Journal of neural engineering

authors： Zwartjes DG,Heida T,Feirabend HK,Janssen ML,Visser-Vandewalle V,Martens HC,Veltink PH

更新日期：2012-10-01 00:00:00

abstract：:We present the results of a 5-year patient follow-up after implantation of an original neuroprosthesis. The system is able to stimulate both epimysial and neural electrodes in such a way that the complete flexor-extensor chain of the lower limb can be activated without using the withdrawal reflex. We demonstrate that ...

journal_title：Journal of neural engineering

authors： Guiraud D,Stieglitz T,Koch KP,Divoux JL,Rabischong P

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Current brain-computer interface (BCI) studies demonstrate the potential to decode neural signals obtained from structured and trial-based tasks to drive actuators with high performance within the context of these tasks. Ideally, to maximize utility, such systems will be applied to a wide range of behavioral ...

journal_title：Journal of neural engineering

authors： Alasfour A,Gabriel P,Jiang X,Shamie I,Melloni L,Thesen T,Dugan P,Friedman D,Doyle W,Devinsky O,Gonda D,Sattar S,Wang S,Halgren E,Gilja V

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Currently, there are some 95 000 people in Europe suffering from upper-limb impairment. Rehabilitation should be undertaken right after the impairment occurs and should be regularly performed thereafter. Moreover, the rehabilitation process should be tailored specifically to both patient and impairment. APPR...

journal_title：Journal of neural engineering

authors： Nissler C,Nowak M,Connan M,Büttner S,Vogel J,Kossyk I,Márton ZC,Castellini C

更新日期：2019-04-01 00:00:00

abstract：:Golgi tendon organs (GTOs) located in the skeletal muscles provide the central nervous system with information about muscle tension. The ensemble firing of all GTO receptors in the muscle has been hypothesized to represent a reliable measure of the whole muscle force but the precision and accuracy of that information ...

journal_title：Journal of neural engineering

authors： Mileusnic MP,Loeb GE

更新日期：2009-06-01 00:00:00

abstract：:We conducted an experiment to determine whether the rhythm with which imagined syllables are produced may be decoded from EEG recordings. High density EEG data were recorded for seven subjects while they produced in imagination one of two syllables in one of three different rhythms. We used a modified second-order bli...

journal_title：Journal of neural engineering

authors： Deng S,Srinivasan R,Lappas T,D'Zmura M

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces. APPROACH:We evaluated the chronic reliability of novel 61-channel micro-electrocorticographic (µECoG) arrays in rats chronically implanted for over one year and usi...

journal_title：Journal of neural engineering

authors： Woods V,Trumpis M,Bent B,Palopoli-Trojani K,Chiang CH,Wang C,Yu C,Insanally MN,Froemke RC,Viventi J

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The advancement of surface electromyogram (sEMG) recording and signal processing techniques has allowed us to characterize the recruitment properties of a substantial population of motor units (MUs) non-invasively. Here we seek to determine whether MU recruitment properties are modified in paretic muscles of ...

journal_title：Journal of neural engineering

authors： Hu X,Suresh AK,Rymer WZ,Suresh NL

更新日期：2015-12-01 00:00:00

abstract：:In this paper, we propose a simple and straightforward algorithm for neural spike sorting. The algorithm is based on the observation that the distribution of a neural signal largely deviates from the uniform distribution and is rather unimodal. The detected spikes to be sorted are first processed with some feature ext...

journal_title：Journal of neural engineering

authors： Tiganj Z,Mboup M

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. In cortic...

journal_title：Journal of neural engineering

authors： Yochum M,Modolo J,Mogul DJ,Benquet P,Wendling F

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:It is known that multi-site interleaved stimulation generates less muscle fatigue compared to single-site synchronous stimulation. However, in the limited number of studies in which intramuscular electrodes were used, the fatigue reduction associated with interleaved stimulation could not consistently be achi...

journal_title：Journal of neural engineering

authors： Eladly A,Del Valle J,Minguillon J,Mercadal B,Becerra-Fajardo L,Navarro X,Ivorra A

更新日期：2020-08-25 00:00:00

abstract：OBJECTIVE:Low-intensity transcranial ultrasound stimulation (TUS) is emerging as a non-invasive brain stimulation technique with superior spatial resolution and the ability to reach deep brain areas. Medical image-based computational modeling could be an important tool for individualized TUS dose control and targeting ...

journal_title：Journal of neural engineering

authors： Pasquinelli C,Montanaro H,Lee HJ,Hanson LG,Kim H,Kuster N,Siebner HR,Neufeld E,Thielscher A

更新日期：2020-07-13 00:00:00

abstract：:A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation a...

journal_title：Journal of neural engineering

authors： Cicione R,Shivdasani MN,Fallon JB,Luu CD,Allen PJ,Rathbone GD,Shepherd RK,Williams CE

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Neuromodulation technologies are increasingly used for improving function after neural injury. To achieve a symbiotic relationship between device and user, the device must augment remaining function, and independently adapt to day-to-day changes in function. The goal of this study was to develop predictive co...

journal_title：Journal of neural engineering

authors： Dalrymple AN,Roszko DA,Sutton RS,Mushahwar VK

更新日期：2020-06-02 00:00:00

abstract：OBJECTIVE:Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits. APPROACH:This progress was enabled by the team-based, inte...

journal_title：Journal of neural engineering

authors： Ereifej ES,Shell CE,Schofield JS,Charkhkar H,Cuberovic I,Dorval AD,Graczyk EL,Kozai TDY,Otto KJ,Tyler DJ,Welle CG,Widge AS,Zariffa J,Moritz CT,Bourbeau DJ,Marasco PD

更新日期：2019-11-12 00:00:00

abstract：OBJECTIVE:Brain-machine interfaces (BMIs) have been proposed in closed-loop applications for neuromodulation and neurorehabilitation. This study describes the impact of different feedback modalities on the performance of an EEG-based BMI that decodes motor imagery (MI) of leg flexion and extension. APPROACH:We execute...

journal_title：Journal of neural engineering

authors： Liu D,Chen W,Lee K,Chavarriaga R,Bouri M,Pei Z,Del R Millán J

更新日期：2017-10-01 00:00:00

abstract：:To properly observe induced connectivity changes after training sessions, one needs a network model that describes individual relationships in sufficient detail to enable observation of induced changes and yet reveals some kind of stability in these relationships. We analyzed spontaneous firing activity in dissociated...

journal_title：Journal of neural engineering

authors： le Feber J,Rutten WL,Stegenga J,Wolters PS,Ramakers GJ,van Pelt J

更新日期：2007-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia. Over the last few years, a considerable effort has been devoted to exploring new biomarkers. Nevertheless, a better understanding of brain dynamics is still required to optimize therapeutic strategies. In this regard, the characterization of mild cognitive...

journal_title：Journal of neural engineering

authors： Bruña R,Poza J,Gómez C,García M,Fernández A,Hornero R

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:We presented a comparative study on the training methodologies of a convolutional neural network (CNN) for the detection of steady-state visually evoked potentials (SSVEP). Two training scenarios were also compared: user-independent (UI) training and user-dependent (UD) training. APPROACH:The CNN was trained...

journal_title：Journal of neural engineering

authors： Ravi A,Beni NH,Manuel J,Jiang N

更新日期：2020-04-08 00:00:00

abstract：OBJECTIVE:Resting state functional connectivity (RSFC) allows the study of functional organization in normal and diseased brain by measuring the spontaneous brain activity generated under resting conditions. Intrinsic optical signal imaging (IOSI) based on multiple illumination wavelengths has been used successfully to...

journal_title：Journal of neural engineering

authors： Kura S,Xie H,Fu B,Ayata C,Boas DA,Sakadžić S

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Neural reflexes regulate immune responses and homeostasis. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus n...

journal_title：Journal of neural engineering

authors： Caravaca AS,Tsaava T,Goldman L,Silverman H,Riggott G,Chavan SS,Bouton C,Tracey KJ,Desimone R,Boyden ES,Sohal HS,Olofsson PS

更新日期：2017-12-01 00:00:00