Abstract:
OBJECTIVE:Patients with amyotrophic lateral sclerosis (ALS) may benefit from brain-computer interfaces (BCI), but the utility of such devices likely will have to account for the functional, cognitive, and behavioral heterogeneity of this neurodegenerative disorder. APPROACH:In this study, a heterogeneous group of patients with ALS participated in a study on BCI based on the P300 event related potential and motor-imagery. RESULTS:The presence of cognitive impairment in these patients significantly reduced the quality of the control signals required to use these communication systems, subsequently impairing performance, regardless of progression of physical symptoms. Loss in performance among the cognitively impaired was accompanied by a decrease in the signal-to-noise ratio of task-relevant EEG band power. There was also evidence that behavioral dysfunction negatively affects P300 speller performance. Finally, older participants achieved better performance on the P300 system than the motor-imagery system, indicating a preference of BCI paradigm with age. SIGNIFICANCE:These findings highlight the importance of considering the heterogeneity of disease when designing BCI augmentative and alternative communication devices for clinical applications.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Geronimo A,Simmons Z,Schiff SJdoi
10.1088/1741-2560/13/2/026002subject
Has Abstractpub_date
2016-04-01 00:00:00pages
026002issue
2eissn
1741-2560issn
1741-2552journal_volume
13pub_type
杂志文章abstract:OBJECTIVE:Depression is a severe mental disorder. However, the neural mechanisms underlying affective interference (difficulties in directing attention away from negative distractors) in depression patients are still not well-understood. In particular, the connections between brain regions remain unclear. Using the emo...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aacdbb
更新日期:2018-10-01 00:00:00
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
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更新日期:2005-09-01 00:00:00
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journal_title:Journal of neural engineering
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doi:10.1088/1741-2560/10/6/066009
更新日期:2013-12-01 00:00:00
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doi:10.1088/1741-2552/ab208c
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journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2552/aa6cbb
更新日期:2017-08-01 00:00:00
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更新日期:2020-11-10 00:00:00
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journal_title:Journal of neural engineering
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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doi:10.1088/1741-2560/7/3/036007
更新日期:2010-06-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of neural engineering
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更新日期:2012-08-01 00:00:00
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doi:10.1088/1741-2560/12/4/043002
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journal_title:Journal of neural engineering
pub_type: 评论,杂志文章
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更新日期:2009-10-01 00:00:00
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