Abstract：
OBJECTIVE:Penetrating cortical neural probe technologies allow investigators to record electrical signals in the brain. Implantation of probes results in acute tissue damage, and microglia density increases around implanted devices over weeks. However, the mechanisms underlying this encapsulation are not well understood in the acute temporal domain. The objective here was to evaluate dynamic microglial response to implanted probes using two-photon microscopy. APPROACH:Using two-photon in vivo microscopy, cortical microglia ∼200 µm below the surface of the visual cortex were imaged every minute in mice with green fluorescent protein-expressing microglia. MAIN RESULTS:Following probe insertion, nearby microglia immediately extended processes toward the probe at (1.6 ± 1.3) µm min(-1) during the first 30-45 min, but showed negligible cell body movement for the first 6 h. Six hours following probe insertion, microglia at distances <130.0 µm (p = 0.5) from the probe surface exhibit morphological characteristics of transitional stage (T-stage) activation, similar to the microglial response observed with laser-induced blood-brain barrier damage. T-stage morphology and microglia directionality indexes were developed to characterize microglial response to implanted probes. Evidence suggesting vascular reorganization after probe insertion and distant vessel damage was also observed hours after probe insertion. SIGNIFICANCE:A precise temporal understanding of the cellular response to microelectrode implantation will facilitate the search for molecular cues initiating and attenuating the reactive tissue response.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Kozai TD,Vazquez AL,Weaver CL,Kim SG,Cui XTdoi
10.1088/1741-2560/9/6/066001subject
Has Abstractpub_date
2012-12-01 00:00:00pages
066001issue
6eissn
1741-2560issn
1741-2552journal_volume
9pub_type
杂志文章abstract：OBJECTIVE:Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool from the physical and engineering sciences that can provide insights r...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab6e8b
更新日期：2020-04-09 00:00:00
abstract：OBJECTIVE:Two-dimensional (2D) movement control is an important issue in brain-computer interfaces (BCIs) research because being able to move, for example, a cursor with the brain will enable patients with motor disabilities to control their environment. However, it is still a challenge to continuously control 2D movem...
journal_title：Journal of neural engineering
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更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods. The optimal threshold for extracting information from auditory cortex has yet to be ide...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab7c19
更新日期：2020-03-03 00:00:00
abstract：OBJECTIVE:Ultrasounds (US) use in neural engineering is so far mainly limited to ablation through high intensity focused ultrasound, but interesting preliminary results show that low intensity low frequency ultrasound could be used instead to modulate neural activity. However, the extent of this modulatory ability of U...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/abae8b
更新日期：2020-10-14 00:00:00
abstract：:A clinically effective retinal prosthesis must evoke localized phosphenes in a retinotopic manner in response to stimulation of each of the retinal electrodes, evoke brightness cues over a wide dynamic range and function within safe stimulus limits. The effects of varying return configuration for retinal stimulation a...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/9/3/036009
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Although electrode size should be miniaturized to provide higher selectivity for neural signal recording and to avoid tissue damage, small sized electrodes induce high impedance, which decreases recording quality. In this work, the electrode surface was modified to increase the effective surface area to lower...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/12/5/056018
更新日期：2015-10-01 00:00:00
abstract：:Microscopic aggregation assay and impedance sensing (IS) were used to monitor a change in in vitro neuron-neuron adhesion in response to blocking of cell adhesion molecules. By blocking neuron-neuron adhesion, migration and aggregation of neuronal cells can be inhibited. This leads to better control of spatial arrange...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/7/5/056003
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:Brain-computer interfaces (BCIs) implemented with real-time functional magnetic resonance imaging (rt-fMRI) use fMRI time-courses from predefined regions of interest (ROIs). To reach best performances, localizer experiments and on-site expert supervision are required for ROI definition. To automate this step,...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/14/1/016004
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:Multimodal neuroimaging approaches are beneficial to discover brain functionalities at high spatial and temporal resolution. In our work, a novel material composition of a microECoG device relying on Parylene HT and indium-tin-oxide (ITO) is presented, which facilitates two-photon imaging of Ca2+ signals and ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab603f
更新日期：2020-02-18 00:00:00
abstract：OBJECTIVE:In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with tetraplegia using a brain-machine interface (BMI). The current study, in the same subject, immediately followed the previous work...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/12/1/016011
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:The various parameters that define a hand movement such as its trajectory, speed, etc, are encoded in distinct brain activities. Decoding this information from neurophysiological recordings is a less explored area of brain-computer interface (BCI) research. Applying non-invasive recordings such as electroence...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/12/6/066019
更新日期：2015-12-01 00:00:00
abstract：:Chronic motor cortex stimulation (MCS) is currently being investigated as a treatment method for Parkinson's disease (PD). Unfortunately, the underlying mechanisms of this treatment are unclear and there are many uncertainties regarding the most effective stimulation parameters and electrode configuration. In this pap...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/9/5/056005
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Wireless control and power harvesting systems that operate injectable, cellular-scale optoelectronic components provide important demonstrated capabilities in neuromodulatory techniques such as optogenetics. Here, we report a radio frequency (RF) control/harvesting device that offers dramatically reduced size...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/12/5/056002
更新日期：2015-10-01 00:00:00
abstract：:Growing neurons navigate complex environments, but in vitro systems for studying neuronal growth typically limit the cues to flat surfaces or a single type of cue, thereby limiting the resulting growth. Here we examined the growth of neurons presented with two-dimensional (2D) substrate-bound cues when these cues were...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/6/1/016002
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Haptic perception of a prosthetic limb or hand is a crucial, but often unmet, need which impacts the utility of the prostheses. In this study, we seek to evaluate the feasibility of a non-invasive transcutaneous nerve stimulation method in generating haptic feedback in a transradial amputee subject as well as...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aabd5d
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits. APPROACH:This progress was enabled by the team-based, inte...
journal_title：Journal of neural engineering
pub_type： 杂志文章,评审
doi：10.1088/1741-2552/ab4869
更新日期：2019-11-12 00:00:00
abstract：OBJECTIVE:By means of subjective psychophysical methods, quality of transmitted speech has been decomposed into three perceptual dimensions named 'discontinuity' (F), 'noisiness' (N) and 'coloration' (C). Previous studies using electroencephalography (EEG) already reported effects of perceived intensity of single quali...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aaf122
更新日期：2019-06-01 00:00:00
abstract：:All of the human prosthetic visual systems implanted so far have been achromatic. Schmidt et al. (1996) reported that at low stimulation intensities their subject reported that phosphenes usually had a specific hue, but when the stimulus intensity was increased, they desaturated to white. We speculate here that previo...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/abd520
更新日期：2020-12-18 00:00:00
abstract：OBJECTIVE:Currently, there are some 95 000 people in Europe suffering from upper-limb impairment. Rehabilitation should be undertaken right after the impairment occurs and should be regularly performed thereafter. Moreover, the rehabilitation process should be tailored specifically to both patient and impairment. APPR...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aaf35f
更新日期：2019-04-01 00:00:00
abstract：:Hybrid electro-optical neural stimulation is a novel paradigm combining the advantages of optical and electrical stimulation techniques while reducing their respective limitations. However, in order to fulfill its promise, this technique requires reduced variability and improved reproducibility. Here we used a compara...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/9/3/036003
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Real-time closed-loop neural feedback control requires the analysis of action potential traces within several milliseconds after they have been recorded from the brain. The current generation of spike clustering algorithms were mostly designed for off-line use and also require a significant amount of computat...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab208c
更新日期：2019-07-30 00:00:00
abstract：OBJECTIVE:Electrocorticography (ECoG) based studies generally analyze features from specific frequency bands selected by manual evaluation of spectral power. However, the definition of these features can vary across subjects, cortical areas, tasks and across time for a given subject. We propose an autoencoder based app...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aaf13f
更新日期：2019-02-01 00:00:00
abstract：:The aim of this paper is to use recent advances in the clinical understanding of the temporal evolution of seizure burden in neonates with hypoxic ischemic encephalopathy to improve the performance of automated detection algorithms. Probabilistic weights are designed from temporal locations of neonatal seizure events ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/9/4/046002
更新日期：2012-08-01 00:00:00
abstract：:We present a micromachined 252-channel ECoG (electrocorticogram)-electrode array, which is made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths. The array subtends an area of approximately 35 mm by 60 mm and is designed to cover large parts of a hemisphere of a macaq...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/6/3/036003
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:Multiresolution analysis (MRA) offers a useful framework for signal analysis in the temporal and spectral domains, although commonly employed MRA methods may not be the best approach for brain computer interface (BCI) applications. This study aims to develop a new MRA system for extracting tempo-spatial-spect...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/10/4/046014
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa8232
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:The past two decades have seen dramatic progress in our ability to model brain signals recorded by electroencephalography, functional near-infrared spectroscopy, etc., and to derive real-time estimates of user cognitive state, response, or intent for a variety of purposes: to restore communication by the seve...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/10/5/056014
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:Low-intensity focused ultrasound stimulation (LIFUS) emerges as an attracting technology for noninvasive modulation of neural circuits, yet the underlying action mechanisms remain unclear. The neuronal intramembrane cavitation excitation (NICE) model suggests that LIFUS excites neurons through a complex inter...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/ab1685
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:Schwann cells (SCs) are primary structural and functional cells in the peripheral nervous system. These cells play a crucial role in peripheral nerve regeneration by releasing neurotrophic factors. This study evaluated the neural differentiation potential effects of stem cells from human exfoliated deciduous ...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2560/13/4/046005
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:Brain-machine interfaces (BMIs) have been proposed in closed-loop applications for neuromodulation and neurorehabilitation. This study describes the impact of different feedback modalities on the performance of an EEG-based BMI that decodes motor imagery (MI) of leg flexion and extension. APPROACH:We execute...
journal_title：Journal of neural engineering
pub_type： 杂志文章
doi：10.1088/1741-2552/aa7df9
更新日期：2017-10-01 00:00:00
