Abstract:
Introduction:Objective: this study aimed to evaluate the association between polymorphisms of INSIG, PCSK9 and FTO genes with anthropometric, biochemical characteristics and presence of metabolic syndrome in patients with severe obesity. Material and methods: the present study enrolled 150 patients with grade II or III obesity, who were submitted to nutritional assessment, blood pressure measurement and peripheral blood collection. INSIG2 (rs75666605), PCSK9 (rs505151), and FTO (rs9939609) polymorphisms were genotyped using TaqMan Pre-Designed SNP Genotyping Assays probes in real time polymerase chain reaction (PCR). The experimental data are processed in SPSS Statistics 22.0 (p < 0.05). Results: in this study, 72.2% of obese subjects had metabolic syndrome (MS). There was a higher prevalence of AA (86.9%), CG (51.1%) and AT (46.2%) genotypes for the PCSK9, INSIG2 and FTO polymorphisms, respectively. There was no association of these polymorphisms with the prevalence of MS (p > 0.05). On the other hand, individuals with at least one variant allele (G) for the INSIG2 gene had higher triglycerides levels, systolic and diastolic blood pressure (p < 0.05). Conclusions: the polymorphism rs7566605 of the INSIG2 gene is associated with higher triglycerides levels and blood pressure values, which are also considered as risk factors for the development of MS. Introducción:Objetivo: este estudio tuvo como objetivo evaluar la asociación entre polimorfismos de los genes INSIG, PCSK9 y FTO con las características antropométricas, bioquímicas y la presencia de síndrome metabólico (SM) en pacientes con obesidad grave. Material y métodos: el presente estudio incluyó 150 pacientes con obesidad de grado II o III, que fueron sometidos a evaluación nutricional, medición de la presión arterial y extracción de sangre periférica. Los polimorfismos INSIG2 (rs75666605), PCSK9 (rs505151) y FTO (rs9939609) fueron genotipados utilizando sondas TaqMan Pre-Designed SNP Genotyping Assays en la reacción en cadena de la polimerasa en tiempo real (PCR). Los datos experimentales se procesan en SPSS Statistics 22.0 (p < 0,05). Resultados: en este estudio, el 72,2% de los sujetos obesos tenían síndrome metabólico (EM). Hubo una mayor prevalencia de genotipos AA (86,9%), CG (51,1%) y AT (46,2%) para los polimorfismos PCSK9, INSIG2 y FTO, respectivamente. No hubo asociación de estos polimorfismos con la prevalencia de SM (p > 0,05). Por otro lado, los individuos con al menos una variante de alelo (G) para el gen INSIG2 tenían niveles más altos de triglicéridos, presión arterial sistólica y diastólica (p < 0,05). Conclusiones: el polimorfismo rs7566605 del gen INSIG2 se asocia con niveles más altos de triglicéridos y valores de presión arterial, que también se consideran factores de riesgo para el desarrollo del síndrome metabólico.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Nicoletti CF,Azevedo RG,Pinhel MAS,Delfino HBP,Nonino CBdoi
10.20960/nh.2359subject
Has Abstractpub_date
2019-07-01 00:00:00pages
604-610issue
3eissn
0212-1611issn
1699-5198journal_volume
36pub_type
杂志文章abstract:Introduction:The current COVID-19 pandemic mainly affects older people, those with obesity or other coexisting chronic diseases such as type-2 diabetes and high blood pressure. It has been observed that about 20 % of patients will require hospitalization, and some of them will need the support of invasive mechanical ve...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03180
更新日期:2020-07-13 00:00:00
abstract:INTRODUCTION:the evaluation of the body fat distribution by anthropometry can serve to identify excess visceral fat. This diagnosis will enable implementation of specific measures to both prevent and treat excess visceral fat in postmenopausal women. OBJECTIVE:the aim of this study was to analyze different anthropomet...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9813
更新日期:2015-12-01 00:00:00
abstract::The term "conditionally essential" (or semi-essential), initially applied to amino acids, has been generalized to other nutrients. A conditionally essential nutrient is a compound usually produced in adequate amounts by endogenous synthesis but that is exogenously required under certain circumstances. Thus, arginine, ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:To determine the nutritional status of patients admitted to hospital for the first time the hematology service and who have not received treatment for cancer, to know if the nutritional status assessed by the EGS-GP and serum albumin related mortality of patients METHODS:A longitudinal, prospective, analyti...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.4.6484
更新日期:2013-07-01 00:00:00
abstract::Objetivos: oligoelementos como zinc (Zn), hierro (Fe) y cobre (Cu) tienen una influencia significativa en el mantenimiento de la función inmune y del metabolismo normales; modulan la función immune e influyen en la susceptibilidad del organismo ante infecciones. Pero la relación entre trazas de estos elementos y la br...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.97
更新日期:2016-03-25 00:00:00
abstract::Diet is an important factor related to the development of numerous diseases. In developing countries like Ecuador, this aspect is not considered as priority however, the study of the incidence of certain diet-related diseases could help to assess consumption habits of a country from a Public Health perspective and sup...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.5.6755
更新日期:2013-09-01 00:00:00
abstract::The problems of disintubation and obstruction of nutritional catheters are common during treatment with enteral nutrition. This prospective study has been designed to evaluate the differences in the frequency of obstruction between two different types of enteral nutrition catheter. Catheter A (Silk, Ibys) with one sin...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:INTRODUCTION:there is a lack of consensus on the benefits of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementations on cognition in dementia and/or Alzheimer's disease (AD) elderly. OBJECTIVE:this study presents a systematic review of the results of randomized clinical trials about this topic. The...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2015.32.2.9111
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Currently there is a growing trend in the prevalence of overweight and obesity. This increased prevalence trend leads to an increase in the costs of health care. OBJECTIVE:The aim of the present study was to analyze the effects on physical fitness and bone mineral density through an intervention program o...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.3.7365
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Food-Based Dietary Guidelines (FBDGs) are an initiative by the United Nations Food and Agriculture Organization (FAO) and the World Health Organization (WHO) designed to help countries establish their own nutrition education principles. Such principles should be expressed through clear and specific message...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.32.3.9362
更新日期:2015-09-01 00:00:00
abstract::A multidisciplinary and multiprofessional debate is established trying to detect and find plausible solutions regarding Home-based and Ambulatory Enteral Nutrition (HBAEN) in Spain, due to the little attention paid by the Administration to the global problem of hyponutrition, the little interest showed by the collecti...
journal_title:Nutricion hospitalaria
pub_type:
doi:
更新日期:2008-03-01 00:00:00
abstract::Malnutrition plays an important role in the rate of postoperative complications that interfere with our surgical activity, impairing immune response mechanisms; synthesis and regeneration processes are damaged and the fight against infection is altered. Preoperative and postoperative administration of diets enriched w...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:tracheoesophageal fistula (TEF) may result from cancer or mechanical ventilation. Endoscopic Gastrostomy or Gastrojejunostomy (PEG/PEG-J) is used for nutritional support. OBJECTIVE:in TEF-patients, evaluating nutritional status when PEG is performed, safety of PEG/PEG-J and clinical outcome. METHODS:from t...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.2.9078
更新日期:2015-08-01 00:00:00
abstract:UNLABELLED:Bone marrow transplant (BMT) implies the treatment with substances which may compromise the nutritional condition, thus increasing the morbido-mortality of these patients. The objective of this study is to evaluate the efficacy of the nutritional support (NS) protocol for patients subjected to a BMT in our c...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Introducción: los problemas relacionados con el peso constituyen un problema importante de salud pública debido a su alta prevalencia y a las adversas consecuencias que tienen para la salud.Objetivo: el objetivo principal de este estudio fue analizar si la depresión y la ansiedad tienen un papel mediador en la relació...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.395
更新日期:2016-07-19 00:00:00
abstract::Introducción: el sobrepeso y la obesidad se asocian a una mayor probabilidad de que el parto finalice en cesárea. Dado que dicho incremento del riesgo podría estar sesgado por variables de confusión como la diabetes o la hipertensión, en el presente trabajo pretendemos determinar si este riesgo persiste tras ser ajust...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.778
更新日期:2016-11-29 00:00:00
abstract::During the last half of the 20th century, Nutrition has evolved in a quick way based on the knowledge of both basic sciences as Biochemistry and Physiology and applied sciences as Epidemiology and Public Health. In that period the nutritional requirements for different population groups grouped by sex, age and physiol...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.2123
更新日期:2018-06-12 00:00:00
abstract:INTRODUCTION:Overweight and obesity are risk factors to appearance of cardiovascular diseases and anthropometry is important as clinical tool for planning and health policymaking at population level. Thus, aim of this work was to compare the simple body fat percentage (%BF) obtained straight by bioeletric impedance (BI...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Body Mass Index (BMI) is one of the most used parameters in bariatric surgery. However, it does not discriminate the weight associated with adiposity. CUN-BAE formula is an equation that calculates Body Fat Percentage or adiposity, based on easily available values (age, sex and BMI). With this new classifi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.2.7581
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:Cardiovascular diseases are the leading cause of death in women after menopause, since after this stage there are profound metabolic and hormonal changes which favor the development of metabolic syndrome. An increase in the percentage of visceral fat may be related to the onset of this syndrome. OBJECTIVE...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1085
更新日期:2017-07-28 00:00:00
abstract::Introduction: Life expectancy is increasing and becoming a characteristic phenomenon of developed countries and, increasingly, of developing countries, such as Brazil. The aging process causes changes of some physiological functions such as loss of smell, taste, loss of appetite, among other things that end up changin...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.v33i1.13
更新日期:2016-02-16 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-09-01 00:00:00
abstract:Introduction:Background and objectives: the aim of the present investigation was to describe the association of this single nucleotide polymorphism (SNP) with fasting glucose levels, serum adipokine levels and diabetes mellitus. Methods: the study involved a population of 1,002 adult obese subjects. Measurements of ant...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.2013
更新日期:2019-03-07 00:00:00
abstract:BACKGROUND & AIMS:By means of this update, the GARIN working group aims to define its position regarding the treatment of patients with diabetes or stress hyperglycaemia and artificial nutrition. In this area there are many aspects of uncertainty, especially in non-critically ill patients. METHODS:Bibliographical revi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2012.27.6.6076
更新日期:2012-11-01 00:00:00
abstract:AIMS:The aim of this study was to assess the food habits and nutritional status of free-living, non-institutionalised, elderly people of Torrevieja, a Spanish city located in the Mediterranean coast. METHODS:Anthropometric and dietary survey (two 24 hour recalls) were assessed in 200 (83 men and 117 women) free-living...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000500038
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Chile has drastically altered eating patterns and physical activity. The main nutritional problem faced by Chilean society is overweight, which arises progressively from an early age. The aim of this study is to determine the nutritional status and compare fitness levels and fasting glucose in students. PAT...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.6.8932
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Dual X-ray absorptiometry (DXA), air displacement plethysmography (ADP), bioelectrical impedance analysis (BIA) and anthropometry are four body composition methods that have been frequently used for the assessment of body fat percentage (%BF) in athletes. However, the agreement between these methods has no...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.760
更新日期:2017-10-24 00:00:00
abstract:BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is a safe procedure and major morbidity is unusual. However, the number of PEG fed patients is increasing all over the world and complications may become more and more frequent. CASE REPORT:We describe a 73 years old woman with persistent vomit after replacement of ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.693
更新日期:2017-03-30 00:00:00
abstract::Severe metabolic alterations frequently occur in critically ill cancer patients; hypercalcemia, hypocalcemia, hyponatremia, tumor lysis syndrome, metabolic complications of renal failure and lactic acidosis. Cancer patients with metabolic emergencies should be treated in a medical oncology department or an intensive c...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nutr hosp.v28in06.6959
更新日期:2013-11-01 00:00:00