Abstract:
Introduction:Background and objectives: the aim of the present investigation was to describe the association of this single nucleotide polymorphism (SNP) with fasting glucose levels, serum adipokine levels and diabetes mellitus. Methods: the study involved a population of 1,002 adult obese subjects. Measurements of anthropometric parameters, blood pressure, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), HOMA-B, lipid profi le and adipocytokines levels were performed. Genotype of MTNR1B gene polymorphism (rs10830963) was evaluated. Results: fasting glucose levels (GG: 101.5 ± 19.1 mg/dl vs GT: 103.5 ± 8.1 units vs TT: 107.2 ± 8.0 mg/dl; p = 0.01) and HOMA-IR (GG: 3.1 ± 1.6 units vs GT: 3.4 ± 1.1 units vs TT: 3.7 ± 1.0 units; p = 0.02) were higher in subjects with GG genotype than in other genotypes. Total adiponectin levels (CC: 20.5 ± 8.4 ng/dl vs CG: 21.8 ± 5.4 ng/dl vs GG: 15.4 ± 1.4 ng/dl; p = 0.02) and HOMA-B (CC: 2.3 ± 0.8 units vs CG: 2.2 ± 1.1 units vs GG: 1.9 ± 0.9 units; p = 0.01) were lower in subjects with GG genotype than GC or CC genotypes. Logistic regression analysis showed an increased risk of hyperglicemia (OR = 1.31, 95% CI = 1.12-2.78, p = 0.03) and diabetes mellitus (OR = 1.37, 95% CI = 1.14-2.86, p = 0.04). Conclusions: this study showed that the MTNR1B rs10830963 polymorphism was associated with increased fasting glucose levels, HOMA-IR, and risk of DM2. This SNP was associated with decreased adiponectin levels and HOMA-B. Introducción:Introducción y objetivos: el objetivo de la presente investigación fue describir la asociación del polimorfi smo del gen MTNR1B (rs10830963) con los niveles de glucosa en ayunas, los niveles séricos de adipocitoquinas y la diabetes mellitus. Métodos: el estudio incluyó una población de 1.002 adultos obesos. Se realizó la determinación de parámetros antropométricos, presión arterial, glucosa en sangre en ayunas, proteína C reactiva (CRP), concentración de insulina, resistencia a la insulina (HOMA-IR), HOMA-B, perfil lipídico y niveles de adipocitoquinas. Se evaluó el genotipo del polimorfi smo del gen MTNR1B (rs10830963). Resultados: los niveles de glucosa en ayunas (GG: 101,5 ± 19,1 mg/dl vs. GT: 103,5 ± 8,1 unidades vs. TT: 107,2 ± 8,0 mg/dl; p = 0,01) y HOMA-IR (GG: 3,1 ± 1,6 unidades vs. GT: 3,4 ± 1,1 unidades vs. TT: 3,7 ± 1,0 unidades, p = 0,02) fueron más altos en sujetos con genotipo GG que en otros genotipos. Los niveles totales de adiponectina (CC: 20,5 ± 8,4 ng/dl vs. CG: 21,8 ± 5,4 ng/dl vs. GG: 15,4 ± 1,4 ng/dl, p = 0,02) y HOMA-B (CC: 2,3 ± 0,8 unidades vs. CG: 2,2 ± 1,1 unidades frente a GG: 1,9 ± 0,9 unidades, p = 0,01) fueron menores en sujetos con genotipo GG que en genotipos GC o CC. El análisis de regresión logística mostró un mayor riesgo de hiperglicemia (OR = 1,31, IC 95% = 1,12-2,78, p = 0,03) y diabetes mellitus (OR = 1,37, IC 95% = 1,14-2,86, p = 0,04). Conclusiones: este estudio mostró que el polimorfi smo MTNR1B rs10830963 se asoció con un aumento de los niveles de glucosa en ayunas, HOMA-IR y riesgo de DM2. Este SNP se asoció con niveles de adiponectina disminuidos y HOMA-B.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
de Luis Román DA,Primo D,Aller R,Izaola Odoi
10.20960/nh.2013subject
Has Abstractpub_date
2019-03-07 00:00:00pages
60-65issue
1eissn
0212-1611issn
1699-5198journal_volume
36pub_type
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000400033
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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journal_title:Nutricion hospitalaria
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doi:10.20960/nh.02685
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-03-01 00:00:00
abstract::Given the negative effect of malnutrition on the immune function, the possibility must be considered that this also affects the clinical progression of AIDS patients. This study was aimed at assessing the state and nutritional support indicated for patients diagnosed as having AIDS. 114 patients admitted to our hospit...
journal_title:Nutricion hospitalaria
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doi:
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.3.6397
更新日期:2013-05-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.1954
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2007-05-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2012.27.6.6154
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02515
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1085
更新日期:2017-07-28 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9760
更新日期:2015-12-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2014.29.1.6891
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder that affects the pyramidal tract, producing progressive motor dysfunctions leading to paralysis. These patients can present with dysphagia, requiring nutritional support with a nasogastric tube or Percutaneous Endoscopic Gastrostomy (PEG). PEG is...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.6.7808
更新日期:2014-12-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.669
更新日期:2017-07-28 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1861
更新日期:2018-10-05 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.3.6455
更新日期:2013-05-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.1590/S0212-16112011000200003
更新日期:2011-03-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.973
更新日期:2017-02-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03348
更新日期:2021-01-13 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9877
更新日期:2015-12-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.1.7491
更新日期:2014-07-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.20960/nh.586
更新日期:2016-09-20 00:00:00
abstract:BACKGROUND:the prognostic value of maximal inspiratory and expiratory pressures on functional capacity and mortality of hospitalized patients are not well established. AIM:to evaluate the prognostic value of respiratory pressures in hospitalized patients. METHODS:patients admitted to a general hospital in Santiago-Ch...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1478
更新日期:2018-05-17 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.4.8495
更新日期:2015-04-01 00:00:00