Abstract:
BACKGROUND AND PURPOSE:The prevalence of silent brain infarcts varies from 8% to 28% in the general elderly population. Silent brain infarcts are associated with increased risk of subsequent stroke and cognitive dysfunction. By definition, silent strokes lack clinically overt stroke-like symptoms and fail to come to clinical attention; however, impaired recall of symptoms may be a potential confounder. Our aim is to report a series of patients with incidentally detected acute and subacute strokes and examine whether they were truly asymptomatic. METHODS:Subjects included in this study were drawn from ongoing dementia research studies at the Memory Ageing and Cognition Center, in which all participants underwent a cranial MRI. Incidental hyperintense lesions on diffusion-weighted imaging with corresponding apparent diffusion coefficient defects indicative of acute/subacute silent stroke were identified. Clinical data for individuals with incidental hyperintense lesions on diffusion-weighted imaging were collated. RESULTS:Six of 649 subjects had incidental hyperintense lesions on diffusion-weighted imaging; on retrospective questioning, 3 recalled symptoms temporally correlated with MRI lesions, which had been reported to but ignored by family members. Two subjects had focal neurological signs. A majority of the subjects with incidental hyperintense lesions on diffusion-weighted imaging had significant cognitive impairment. CONCLUSIONS:A significant number of strokes may be "silent" due to lack of awareness of stroke-like symptoms in the elderly and their families. Enhanced stroke prevention education strategies are needed for the elderly population and, in particular, for their families.
journal_name
Strokejournal_title
Strokeauthors
Saini M,Ikram K,Hilal S,Qiu A,Venketasubramanian N,Chen Cdoi
10.1161/STROKEAHA.112.666461subject
Has Abstractpub_date
2012-11-01 00:00:00pages
3102-4issue
11eissn
0039-2499issn
1524-4628pii
STROKEAHA.112.666461journal_volume
43pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate anticoagulation use after a first major bleed on warfarin or dabigatran and, second, to compare effectiveness and safety o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015150
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke and intracranial arterial obstructions have a poor prognosis and a high probability of deteriorating at 24 hours. We aimed to evaluate the diagnostic accuracy of power motion mode Doppler (PMD-TCD) compared with CT angiography as standard in diagnosing intracra...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.542704
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In most European societies and in the United States, the percentage of patients ≥80 years has been rising over the past century. The present study was conducted to observe this demographic change and its impact on patients with intracerebral hemorrhage (ICH). METHODS:We reviewed patients' data w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.644716
更新日期:2012-04-01 00:00:00
abstract::Four university centers collaborated to contribute 1158 patients with acute episodes of cerebrovascular disease to the pilot Stroke Data Bank, initiated by NINCDS in 1978. During the pilot project a standard set of data collection forms were developed and used at each of the collaborating centers. Data on clinical cou...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.4.740
更新日期:1984-07-01 00:00:00
abstract::Experimental subarachnoid hemorrhage was induced in 52 adult male Wistar rats by microsurgical transclival basilar artery puncture. Telencephalic blood flow measured in 24 rats with subarachnoid hemorrhage was compared with that in 23 sham-operated rats and 10 unoperated control rats using the [14C]butanol indicator f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.4.577
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration of deployed FD. We studied the resultant hemodynamic changes after implantation of FDs using computational fluid dynamic simulations based on micro-computed ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001202
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The presence of known restriction fragment length polymorphisms in the apoprotein A-I-C-III gene cluster, which encodes their respective apoproteins, was investigated using the restriction enzymes Sac I and Pst I to determine the potential role of genetic variations for stroke risk in an American...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1257
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. METHODS:This incident ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.30.10.2013
更新日期:1999-10-01 00:00:00
abstract::In a case-control study of 73 cases of cerebral hematoma diagnosed by CT scan, significant risk factors were history of hypertension, chronic alcoholism, evidence of hepatic disease, EKG abnormalities and high hematocrit values. Initial blood pressure was significantly higher in cases, but blood pressure on the third ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1126
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial Doppler (TCD) and carotid duplex (CD) provide rapid and safe screening for stroke patients but are highly operator dependent. We explored the feasibility of telemedicine (TM)-guided TCD/CD administered by a health care provider inexperienced with ultrasound. METHODS:Dual video scree...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196988.45318.97
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is associated with a temporal pattern of stroke incidence. We hypothesized that natural oscillations in gene expression controlling circadian rhythm affect the severity of neuronal injury. We moreover predict that heme oxygenase-1 (HO-1/Hmox1) and its product carbon ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.016165
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Declining trends in the incidence and mortality of stroke have been observed in Finland since the beginning of the 1980s until 1997. In this study we analyzed the trends in fatal and nonfatal strokes in Finland during 1991-2002. METHODS:The Finnish Hospital Discharge Register was linked to the N...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000152945.28543.4a
更新日期:2005-02-01 00:00:00
abstract::Two hundred fifteen consecutive patients with cerebrovascular events were evaluated prospectively for the incidence and characteristics of headache. Of 163 patients able to communicate, headache occurred in 29% with bland infarcts, 57% with parenchymal hemorrhage, 36% with transient ischemic attacks and 17% with lacun...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.6.1009
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the short-term risks of stroke and types of stroke associated with isolated systolic hypertension (ISH) and borderline isolated systolic hypertension (BISH) have been described, the long-term effects of these hypertensive conditions, particularly in younger individuals, are unclear. We p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000039402.05613.0f
更新日期:2002-12-01 00:00:00
abstract::The trends in age adjusted and age and sex specific mortality rates for the period 1968-1980 are compared for ischaemic heart disease and cerebrovascular disease. For both sexes and at all ages over 45 the mortality rates for cerebrovascular disease have fallen significantly. However, the mortality rates for ischaemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.5.582
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm grow...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.008198
更新日期:2015-05-01 00:00:00
abstract::Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.025784
更新日期:2019-08-01 00:00:00
abstract::In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this mate...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.670
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is expanding literature to show that certain patients admitted during the weekend have worse outcomes than similar patients admitted during the week. Although many clinicians have hypothesized the presence of this "weekend effect" with patients with intracerebral hemorrhage, there is a pauc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.546572
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysregulation of vessel wall formation, growth, and maintenance may confer susceptibility of stroke. METHODS:We tested the hypothesis that variants in 2 genes encoding vascular endothelial growth factor and vascular endothelial growth factor receptor-2 are associated with susceptibility to strok...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.554394
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arachidonic acid that is released following cerebral ischemia can be metabolized to 20-hydroxyeicosatetraenoic acid (20-HETE). 20-HETE is a potent vasoconstrictor that may contribute to ischemic injury. This study examined the effects of blockading the synthesis of 20-HETE with TS-011 on infarct ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000217398.37075.07
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000170645.40562.09
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The inflammatory response within cerebral infarcts may have an influence on tissue damage. Since old animals with an impaired immune response have decreased inflammation after experimental cerebral infarction, we postulated that female animals with an increased immune response will have an increa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.3.498
更新日期:1996-03-01 00:00:00
abstract::Hyperventilation to extremely low arterial carbon dioxide tension (PaCO2) has been used in the management of persistent pulmonary hypertension in newborn infants. With progressive hypocarbia, cerebral vasoconstriction occurs, raising the concern that extreme hypocarbia may result in cerebral oxygen deprivation. Theref...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.11.1365
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019276
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000254607.48765.cb
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is the gold standard to assess patients with acute stroke. We aimed to examine the feasibility and reliability of prehospital real-time cellular video phone (VP) in performing the NIHSS. METHODS:Forty physicians prospectively performed a sim...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.600296
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to examine the relationship between depressive symptoms and the incidence of stroke among Japanese men and women. METHODS:A 10.3-year prospective study on the relationship between depressive symptoms and the incidence of stroke was conducted with 901 men and women aged 40 to 78 years i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.903
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0202.102728
更新日期:2002-02-01 00:00:00
abstract::Background and Purpose- Imaging is frequently used to select acute stroke patients for intra-arterial therapy. Quantitative cerebral blood flow can be measured noninvasively with arterial spin labeling magnetic resonance imaging. Cerebral blood flow levels in the contralateral (unaffected) hemisphere may affect capaci...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.119.026499
更新日期:2019-12-01 00:00:00