On the role of different age groups during pertussis epidemics in California, 2010 and 2014.

Abstract:

:There is limited information on the roles of different age groups in propagating pertussis outbreaks, and the temporal changes in those roles since the introduction of acellular pertussis vaccines. The relative roles of different age groups in propagating the 2010 and the 2014 pertussis epidemics in California were evaluated using the relative risk (RR) statistic that measures the change in the group's proportion among all detected cases before vs. after the epidemic peak. For the 2010-11 epidemic, evidence for a predominant transmission age group was weak, with the largest RR estimates being 1.26 (95% CI 1.08-1.46) (aged 11-13 years); 1.19 (1.01-1.4) (aged 9-10 years); 1.17 (0.86-1.59) (aged 14-15 years); 1.12 (0.86-1.46) (aged 16-19 years) and 1.1 (0.89-1.36) (aged 7-8 years). The 2014 epidemic showed a strong signal of the role of older adolescents, with the highest RR estimate being in those aged 14-15 years (RR = 1.83, 1.61-2.07), followed by adolescents aged 16-19 years (RR = 1.41, 1.24-1.61) and 11-13 years (RR = 1.26, 1.12-1.41), with lower RR estimates in other age groups. As the time following introduction of acellular pertussis vaccines in California progressed, older adolescents played an increasing role in transmission during the major pertussis outbreaks. Booster pertussis vaccination for older adolescents with vaccines effective against pertussis transmission should be considered with the aim of mitigating future pertussis epidemics in the community.

journal_name

Epidemiol Infect

authors

Mahmud AS,Lipsitch M,Goldstein E

doi

10.1017/S0950268819000761

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

e184

eissn

0950-2688

issn

1469-4409

pii

S0950268819000761

journal_volume

147

pub_type

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