Erythema multiforme after orf virus infection: a report of two cases and literature review.

Abstract:

:Orf virus has a worldwide distribution among sheep and goats. The hypersensitivity reaction erythema multiforme (EM) is a known complication of orf infection in humans; however, its occurrence is poorly understood and has not been extensively reviewed. We present two unrelated cases of orf-associated EM, and a review of the literature, highlighting important clinical, epidemiological and immunological aspects of this condition. Orf and its associated complications can occur in rural areas, as well as urban settings, where it is less well-known, through religious or cultural practices involving animal slaughter. Obtaining a history of animal exposures from patients with lesions suspicious for orf and secondary skin eruptions can guide diagnosis and identification of the inciting immune stimulus. Determining the pathophysiology and relative contribution of host and viral factors contributing to EM and other orf-associated hypersensitivity reactions could facilitate the identification of risk factors and inform treatment decisions.

journal_name

Epidemiol Infect

authors

Joseph RH,Haddad FA,Matthews AL,Maroufi A,Monroe B,Reynolds M

doi

10.1017/S0950268814000879

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

385-90

issue

2

eissn

0950-2688

issn

1469-4409

pii

S0950268814000879

journal_volume

143

pub_type

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