Estimation of the effect of neutropenia on rates of clinical bacteraemia in HIV-infected patients.

Abstract:

:A retrospective cohort study was conducted to quantitate the relationship between neutropenia and rates of clinical bacteraemia among adults with HIV infection receiving medical care at one institution between 1991-5. The primary exposure, absolute neutrophil count (ANC), was summarized as mean ANC within a given week, using a five-level stratification (reference > 1000/microl). ANC stratum-specific rates of bacteraemia were calculated, by organism type. Linear trend tests were performed to assess dose-response relationship between neutropenia and rates of bacteraemia. The cohort included 1645 patients contributing 26,785 patients-weeks and 191 episodes of bacteraemia. The unadjusted effect of neutropenia was most evident for bacteraemia due to E. coli (RR 3.4), Klebsiella pneumoniae (RR 16.7), and P. aeruginosa (RR 10.4). For bacteraemia due to any of these three organisms (47 episodes), with reference ANC > 1000/microl, relative rates were: 751-1000/microl, 1.12; 501-750/microl, 2.11; 251-500/microl, 13.58; 0-250/microl, 21.89.

journal_name

Epidemiol Infect

authors

Caperna J,Barber RE,Toerner JG,Mathews WC

doi

10.1017/s095026889700842x

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

71-80

issue

1

eissn

0950-2688

issn

1469-4409

journal_volume

120

pub_type

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