Abstract:
:To analyse sociodemographic, viroimmunological and clinical parameters in different HIV-transmission categories at baseline and during treatment, 3039 patients were followed up for 12 months after the initiation of a nelfinavir-based regimen. Multiple baseline parameters were significantly different in the diverse categories, including CD4 counts (P<0.0001) and viral load (P=0.02). There were differences in the groups regarding the CD4 response (P=0.01), but not the virological response (P=0.4), to therapy over time. Multivariate analyses revealed that transmission categories were significantly related to baseline CD4 counts (P=0.01), viral load at 12 months (P=0.0006), poorer adherence to therapy of injecting drug users (IDUs) vs. each of the other groups (P<0.001) and failure to complete the 12-month evaluation of IDU vs. heterosexual (P=0.003) and men who have sex with men (MSM) groups (P=0.02). We conclude that transmission categories had a significant influence on several baseline parameters and viroimmunological outcomes following highly active antiretroviral therapy (HAART), as well as on adherence to therapy and to medical appointments.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Collazos J,Asensi V,Carton JA,Grupo Español para el Estudio Multifactorial de la Adherencia (GEEMA).doi
10.1017/S0950268809991282subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1016-24issue
7eissn
0950-2688issn
1469-4409pii
S0950268809991282journal_volume
138pub_type
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