Abstract:
:This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) ⩽1·5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected >6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons. The PTR was 85·7%. The PFR was 20·8% but fell to 5·9% in samples from treatment-naive individuals with long-standing infection (>1 year), and to 0 in samples with the circulating recombinant form CRF35 AD. A LAg-based algorithm with a PFR of 3·3% estimated a similar incidence trend to that calculated by analyses based on HIV-1 seroconversions. In recently infected persons indicated by LAg, the median log10 HIV RNA level was high (5·30, interquartile range 4·56-5·90). LAg can help identify highly infectious HIV(+) individuals as it accurately identifies recent infections and is correlated with the HIV RNA level. It can also produce reliable estimates of HIV-1 incidence.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Nikolopoulos GK,Katsoulidou A,Kantzanou M,Rokka C,Tsiara C,Sypsa V,Paraskevis D,Psichogiou M,Friedman S,Hatzakis Adoi
10.1017/S0950268816002417subject
Has Abstractpub_date
2017-01-01 00:00:00pages
401-412issue
2eissn
0950-2688issn
1469-4409pii
S0950268816002417journal_volume
145pub_type
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