Seroprevalence of SARS coronavirus antibody in household contacts.

Abstract:

:Between March and July 2003, 671 cases of severe acute respiratory syndrome (SARS) were diagnosed in Taiwan with a total of 84 fatalities. After the epidemic, a serological survey was conducted involving the asymptomatic household contacts. Household contacts of 13 index patients were enrolled in the study. Contact history and clinical symptoms of the household contacts were recorded by standardized questionnaires. Blood samples of patients and household contacts were collected at least 28 days after symptom onset in the index patients or household exposure in the contacts for SARS-associated coronavirus (SARS-CoV) IgG testing. On the basis of this investigation, 29 persons (25 adults and 4 children) were identified as having had unprotected exposure to the index cases before infection-control practices were implemented. Laboratory evaluation of clinical specimens showed no evidence of transmission of SARS-CoV infection to any contacts. This investigation demonstrated that subclinical transmission among household contacts was low in the described setting.

journal_name

Epidemiol Infect

authors

Lee CC,Chen SY,Chang IJ,Tsai PC,Lu TC,Wu PL,Chen WJ,Huang LM,Chang SC

doi

10.1017/S0950268805004541

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1119-22

issue

6

eissn

0950-2688

issn

1469-4409

pii

S0950268805004541

journal_volume

133

pub_type

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