Full-genome sequence analysis of an uncommon norovirus genotype, GII.21, from South Korea.

Abstract:

:Noroviruses (NoVs) are major causal agents of acute gastroenteritis in humans. NoV GII.4 is the predominant genotype globally. However, uncommon and minor types of NoVs are consistently detected and some have been shown to dominate over GII.4. Therefore, the prevalence of dominant and uncommon NoVs makes the identification of these viruses important for the prediction and prevention of pandemics. In this study, the full-genome sequence of a NoV (strain JW) detected in Korea was extensively characterized. The full-length genome was 7510 nucleotides long, and phylogenetic analysis based on the whole-genome sequences, including open reading frame (ORF)1, ORF2, and ORF3, indicated that it belonged to the GII.21 genotype. Strain JW showed maximum identity with strain YO284; however, comparison of the amino acid sequence of ORF2, which functions as an antigen, showed substitutions in several amino acids. GII.21 is not a prevalent epidemiological agent of acute gastroenteritis in humans, but it is consistently found in gastroenteritis patients from several countries. The present study provides the first full-genome sequence analysis of NoV GII.21 isolated from a patient in Korea. Our findings provide not only valuable genome information but also data for epidemiology studies, epidemic prevention, and vaccine development strategies.

journal_name

Epidemiol Infect

authors

Lee JW,Lee SG,Cho HG,Park YJ,Yun JW,Park CJ,Paik SY

doi

10.1017/S0950268817001273

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

2231-2240

issue

11

eissn

0950-2688

issn

1469-4409

pii

S0950268817001273

journal_volume

145

pub_type

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