Abstract:
:Herpes simplex virus (HSV) is one of the most commonly identified infectious aetiologies of encephalitis in North America and Europe. The epidemiology of encephalitis beyond these regions, however, is poorly defined. During 2009-2012 we enrolled 313 patients in a multicentre prospective study of encephalitis in Peru, 45 (14·4%) of whom had confirmed HSV infection. Of 38 patients with known HSV type, 84% had HSV-1 and 16% had HSV-2. Patients with HSV infection were significantly more likely to present in the summer months (44·4% vs. 20·0%, P = 0·003) and have nausea (60·0% vs. 39·8%, P = 0·01) and rash (15·6% vs. 5·3%, P = 0·01) compared to patients without HSV infection. These findings highlight differences in the epidemiology and clinical presentation of HSV encephalitis outside of the Northern Hemisphere that warrant further investigation. Furthermore, there is an urgent need for improved HSV diagnostic capacity and availability of intravenous acyclovir in Peru.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Montano SM,Mori N,Nelson CA,Ton TG,Celis V,Ticona E,Sihuincha M,Tilley DH,Kochel T,Zunt JR,Meningoencephalitis Working Group.doi
10.1017/S0950268815003222subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1673-8issue
8eissn
0950-2688issn
1469-4409pii
S0950268815003222journal_volume
144pub_type
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