Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins.

Abstract:

:Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73-94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42% vs. partners: 51%, P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90% vs. DZ: 88%, P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection--even under continuous within-partnership exposure--appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.

journal_name

Epidemiol Infect

authors

Mortensen LH,Maier AB,Slagbom PE,Pawelec G,Derhovanessian E,Petersen I,Jahn G,Westendorp RG,Christensen K

doi

10.1017/S0950268811001397

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

835-41

issue

5

eissn

0950-2688

issn

1469-4409

pii

S0950268811001397

journal_volume

140

pub_type

杂志文章
  • Prevalence of tuberculosis infection in healthcare workers of the public hospital network in Medellín, Colombia: a Bayesian approach.

    abstract::A latent tuberculosis infection (LTBI) prevalence survey was conducted using tuberculin skin test (TST) and Quantiferon test (QFT) in 1218 healthcare workers (HCWs) in Medellín, Colombia. In order to improve the prevalence estimates, a latent class model was built using a Bayesian approach with informative priors on t...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816003150

    authors: Ochoa J,León AL,Ramírez IC,Lopera CM,Bernal E,Arbeláez MP

    更新日期:2017-04-01 00:00:00

  • Retrospective survey of Chikungunya disease in Réunion Island hospital staff.

    abstract::Réunion Island (Indian Ocean) has been suffering from its first known Chikungunya virus (CHIKV) epidemic since February 2005. To achieve a better understanding of the disease, a questionnaire was drawn up for hospital staff members and their household. CHIKV infected about one-third of the studied population, the prop...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268807008424

    authors: Staikowsky F,Le Roux K,Schuffenecker I,Laurent P,Grivard P,Develay A,Michault A

    更新日期:2008-02-01 00:00:00

  • Are food exposures obtained through commercial market panels representative of the general population? Implications for outbreak investigations.

    abstract::Current methods of control recruitment for case-control studies can be slow (a particular issue for outbreak investigations), resource-intensive and subject to a range of biases. Commercial market panels are a potential source of rapidly recruited controls. Our study evaluated food exposure data from these panel contr...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819000219

    authors: Inns T,Curtis D,Crook P,Vivancos R,Gardiner D,McCarthy N,Mook P

    更新日期:2019-01-01 00:00:00

  • Social networks and HCV viraemia in anti-HCV-positive rural drug users.

    abstract::Although social networks are known to play an important role in drug-using behaviours associated with hepatitis C virus (HCV) infection, literature on social networks and HCV is inconsistent. This exploratory study examined HCV RNA distribution within a social network of anti-HCV-positive non-medical prescription opio...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268812000696

    authors: Young AM,Jonas AB,Havens JR

    更新日期:2013-02-01 00:00:00

  • A meta-analysis of the association between obesity and COVID-19.

    abstract::Owing to limited data, we conducted a meta-analysis to re-evaluate the relationship between obesity and coronavirus-2019 (COVID-19). Literature published between 1 January 2020 and 22 August 2020 was comprehensively analysed, and RevMan3.5 was used for data analysis. A total of 50 studies, including data on 18 260 378...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,meta分析

    doi:10.1017/S0950268820003027

    authors: Yang J,Ma Z,Lei Y

    更新日期:2020-12-22 00:00:00

  • A secondary school outbreak of mumps following the childhood immunization programme in England and Wales.

    abstract::Since the introduction of routine measles, mumps and rubella immunization for children in England and Wales in 1988, the incidence of mumps has declined steadily. We describe an outbreak of mumps in 1996 attacking 34 of a cohort of 98 schoolchildren born in 1982 and 1983. This is the largest outbreak in the UK since t...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s095026889900343x

    authors: Wehner H,Morris R,Logan M,Hunt D,Jin L,Stuart J,Cartwright K

    更新日期:2000-02-01 00:00:00

  • Serodiagnosis of leptospirosis in China by the one-point MCA method.

    abstract::The one-point MCA method is very simple to perform and useful as a screening test in diagnosing leptospirosis in routine clinical laboratories. The kit, sensitized with six serovars occurring in Japan, was also useful in detecting serum antibodies of patients with leptospirosis in China. ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s095026880006787x

    authors: Arimitsu Y,Matuhasi T,Kobayashi S,Sato T,Cui JJ

    更新日期:1987-10-01 00:00:00

  • A geostatistical investigation of agricultural and infrastructural risk factors associated with primary verotoxigenic E. coli (VTEC) infection in the Republic of Ireland, 2008-2013.

    abstract::Ireland reports the highest incidence of verotoxigenic Escherichia coli (VTEC) infection in Europe. This study investigated potential risk factors for confirmed sporadic and outbreak primary VTEC infections during 2008-2013. Overall, 989 VTEC infections including 521 serogroup O157 and 233 serogroup O26 were geo-refer...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026881600193X

    authors: Óhaiseadha C,Hynds PD,Fallon UB,O'Dwyer J

    更新日期:2017-01-01 00:00:00

  • The effectiveness of Haemophilus influenzae type b conjugate vaccines in a high risk population measured using immunization register data.

    abstract::The Northern Territory of Australia has had historically very high incidence rates of invasive Haemophilus influenzae type b disease in children less than 5 years of age, with the burden of disease greatest among Aboriginal infants less than 12 months. This study documents the impact of conjugate Hib vaccines introduc...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268801005155

    authors: Markey P,Krause V,Boslego JW,Coplan PM,Dargan JM,Kaplan KM

    更新日期:2001-02-01 00:00:00

  • Patient and strain characteristics in relation to the outcome of meningococcal disease: a multivariate analysis.

    abstract::To investigate the joint association of patient and strain characteristics with the outcome of meningococcal disease (MD), data were collected on 563 consecutive cases of MD reported between 1989 and 1990 in The Netherlands. The meningococcal isolates were characterized with regard to their surface characteristics. Se...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800057472

    authors: Scholten RJ,Bijlmer HA,Valkenburg HA,Dankert J

    更新日期:1994-02-01 00:00:00

  • Multistate outbreak of Salmonella Paratyphi B variant L(+) tartrate(+) and Salmonella Weltevreden infections linked to imported frozen raw tuna: USA, March-July 2015.

    abstract::Foodborne non-typhoidal salmonellosis causes approximately 1 million illnesses annually in the USA. In April 2015, we investigated a multistate outbreak of 65 Salmonella Paratyphi B variant L(+) tartrate(+) infections associated with frozen raw tuna imported from Indonesia, which was consumed raw in sushi. Forty-six (...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268818001462

    authors: Hassan R,Tecle S,Adcock B,Kellis M,Weiss J,Saupe A,Sorenson A,Klos R,Blankenship J,Blessington T,Whitlock L,Carleton HA,Concepción-Acevedo J,Tolar B,Wise M,Neil KP

    更新日期:2018-08-01 00:00:00

  • A school outbreak of pandemic (H1N1) 2009 infection: assessment of secondary household transmission and the protective role of oseltamivir.

    abstract::In mid-June 2009, an outbreak of pandemic (H1N1) 2009 (pH1N1) infection occurred in a secondary school in Hong Kong. We carried out an epidemiological investigation to delineate the characteristics of the outbreak, gauge the extent of secondary household transmission, and assess the protective role of oseltamivir in h...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810001445

    authors: Leung YH,Li MP,Chuang SK

    更新日期:2011-01-01 00:00:00

  • Compliance with Clostridium difficile treatment guidelines: effect on patient outcomes.

    abstract::Guidelines for the severity classification and treatment of Clostridium difficile infection (CDI) were published by Infectious Diseases Society of America (IDSA)/Society for Healthcare Epidemiology of America (SHEA) in 2010; however, compliance and efficacy of these guidelines has not been widely investigated. This pr...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268817000644

    authors: Crowell KT,Julian KG,Katzman M,Berg AS,Tinsley A,Williams ED,Koltun WA,Messaris E

    更新日期:2017-08-01 00:00:00

  • Most Campylobacter subtypes from sporadic infections can be found in retail poultry products and food animals.

    abstract::The subtypes of Campylobacter isolates from human infections in two Danish counties were compared to isolates from retail food samples and faecal samples from chickens, pigs and cattle. During a 1-year period, 1285 Campylobacter isolates from these sources were typed by two methods: 'Penner' heat-stable serotyping and...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268805005509

    authors: Nielsen EM,Fussing V,Engberg J,Nielsen NL,Neimann J

    更新日期:2006-08-01 00:00:00

  • The incidence of pneumonia using data from a computerized general practice database.

    abstract::Despite being widely recognized as a significant public health problem there are surprisingly few contemporary data available on the incidence of pneumonia in the UK. We conducted a general population-based cohort study to determine the incidence of pneumonia in general practice in the United Kingdom. Data were obtain...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268808001428

    authors: Myles PR,McKeever TM,Pogson Z,Smith CJ,Hubbard RB

    更新日期:2009-05-01 00:00:00

  • Contamination of hands and work surfaces with Salmonella enteritidis PT4 during the preparation of egg dishes.

    abstract::Salmonella enteritidis PT4 was recovered from fingers following the breaking of intact shell eggs artificially contaminated in the contents with the bacterium. Kitchen utensils used to mix egg dishes were salmonella-positive, sometimes after washing. Following the preparation of batter or the mixing of eggs, S. enteri...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800068412

    authors: Humphrey TJ,Martin KW,Whitehead A

    更新日期:1994-12-01 00:00:00

  • An outbreak of viral gastroenteritis associated with adequately prepared oysters.

    abstract::Over Christmas 1993, an outbreak of food poisoning occurred among guests in a hotel in South West Scotland. Evidence from a cohort study strongly suggested that raw oysters were the vehicle for infection, probably due to a Small Round Structured Virus (SRSV). Detailed enquiry about the source and preparation of the oy...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800058222

    authors: Chalmers JW,McMillan JH

    更新日期:1995-08-01 00:00:00

  • Epidemiology of classic and AIDS-related Kaposi's sarcoma in the USA: incidence, survival, and geographical distribution from 1975 to 2005.

    abstract::This study aimed to examine trends in incidence, geographical distribution, and survival of classic and AIDS-related Kaposi's sarcoma (KS) in the general US population using Surveillance, Epidemiology, and End Results (SEER) tumour registries with 12 066 patients diagnosed with KS between 1975 and 2005. Although the a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268812000325

    authors: Armstrong AW,Lam KH,Chase EP

    更新日期:2013-01-01 00:00:00

  • Seroepidemiological studies on the occurrence of common respiratory infections in paediatric student nurses and medical technology students.

    abstract::The occupational risk of acquiring minor respiratory infections for paediatric student nurses was estimated by performing serological examinations with influenza A, B, C, parainfluenza, mumps, respiratory syncytial virus, adenovirus and Mycoplasma pneumoniae at 6-month intervals over a period of 4 years in paediatric ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800061707

    authors: Gerth HJ,Grüner C,Müller R,Dietz K

    更新日期:1987-02-01 00:00:00

  • Influenza and its relationship to circulatory disorders.

    abstract::Three sources of data (general practice episode data from the Weekly Returns Service of the Royal College of General Practitioners, national hospital admission data for England and national mortality data by date of death) were examined separately in each winter (1994/1995 to 1999/2000) to investigate the impact of in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268804003231

    authors: Fleming DM,Cross KW,Pannell RS

    更新日期:2005-04-01 00:00:00

  • Norovirus waterborne outbreak in Chalkidiki, Greece, 2015: detection of GI.P2_GI.2 and GII.P16_GII.13 unusual strains.

    abstract::Noroviruses, along with rotaviruses, are among the leading causes of gastroenteritis worldwide and novel strains are periodically emerging. In August 2015, an unusual increase of gastroenteritis cases occurred in a touristic district in Kassandra peninsula, Chalkidiki, Northern Greece. Seven stool specimens from cases...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819000852

    authors: Tryfinopoulou K,Kyritsi M,Mellou K,Kolokythopoulou F,Mouchtouri VA,Potamiti-Komi M,Lamprou A,Georgakopoulou T,Hadjichristodoulou C

    更新日期:2019-01-01 00:00:00

  • Predicting treatment failure, death and drug resistance using a computed risk score among newly diagnosed TB patients in Tamaulipas, Mexico.

    abstract::The purpose of this study was to develop a method for identifying newly diagnosed tuberculosis (TB) patients at risk for TB adverse events in Tamaulipas, Mexico. Surveillance data between 2006 and 2013 (8431 subjects) was used to develop risk scores based on predictive modelling. The final models revealed that TB pati...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268817001911

    authors: Abdelbary BE,Garcia-Viveros M,Ramirez-Oropesa H,Rahbar MH,Restrepo BI

    更新日期:2017-10-01 00:00:00

  • Epidemiology of Salmonella typhimurium: ribosomal DNA analysis of strains from human and animal sources.

    abstract::Salmonella typhimurium is the most frequently identified serovar of Salmonella in Italy. This serovar is characterized by the widespread dissemination among human and non-human sources of phenotypically and genetically well-differentiated clones. In this study 457 strains of S. typhimurium isolated in Italy in the yea...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800050974

    authors: Nastasi A,Mammina C,Villafrate MR

    更新日期:1993-06-01 00:00:00

  • Surveillance of listeriosis in the Tel Aviv District, Israel, 2010-2015.

    abstract::This study analyses the epidemiologic, clinical and molecular findings of all culture-confirmed cases of listeriosis notified from 2010 to 2015 in the Tel Aviv District, which is known to have high rates of listeriosis. All clinical isolates of Listeria monocytogenes were subtyped using two-enzyme pulsed-field gel ele...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268817003004

    authors: Salama M,Amitai Z,Ezernitchi AV,Sheffer R,Jaffe J,Rahmani S,Leshem E,Valinsky L

    更新日期:2018-02-01 00:00:00

  • Application of multiblock modelling to identify key drivers for antimicrobial use in pig production in four European countries.

    abstract::Antimicrobial use in pig farming is influenced by a range of risk factors, including herd characteristics, biosecurity level, farm performance, occurrence of clinical signs and vaccination scheme, as well as farmers' attitudes and habits towards antimicrobial use. So far, the effect of these risk factors has been expl...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268818000742

    authors: Collineau L,Bougeard S,Backhans A,Dewulf J,Emanuelson U,Grosse Beilage E,Lehébel A,Lösken S,Postma M,Sjölund M,Stärk KDC,Visschers VHM,Belloc C

    更新日期:2018-06-01 00:00:00

  • Meteorological factors and its association with hand, foot and mouth disease in Southeast and East Asia areas: a meta-analysis.

    abstract::Since the late 1990s, hand, foot and mouth disease (HFMD) has become a common health problem that mostly affects children and infants in Southeast and East Asia. Global climate change is considered to be one of the major risk factors for HFMD. This study aimed to assess the correlation between meteorological factors a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268818003035

    authors: Duan C,Zhang X,Jin H,Cheng X,Wang D,Bao C,Zhou M,Ahmad T,Min J

    更新日期:2018-11-19 00:00:00

  • Pseudomonas aeruginosa dose response and bathing water infection.

    abstract::Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theory development. Thre...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,评审

    doi:10.1017/S0950268813002690

    authors: Roser DJ,van den Akker B,Boase S,Haas CN,Ashbolt NJ,Rice SA

    更新日期:2014-03-01 00:00:00

  • The Clostridium perfringens enterotoxin from equine isolates; its characterization, sequence and role in foal diarrhoea.

    abstract::During a survey of foal diarrhoea between 1991 and 1994, Clostridium perfringens was significantly associated with disease with 56% of cases infected [1]. The contribution of enterotoxigenic C. perfringens to this association, was assessed by use of the reverse passive latex agglutination test for enterotoxin (RPLA; O...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268897008534

    authors: Netherwood T,Binns M,Townsend H,Wood JL,Mumford JA,Chanter N

    更新日期:1998-03-01 00:00:00

  • The stimulating effect of fosfomycin, an antibiotic in common use in Japan, on the production/release of verotoxin-1 from enterohaemorrhagic Escherichia coli O157:H7 in vitro.

    abstract::In 1996 Japan had a big outbreak of enterohaemorrhagic Escherichia coli (EHEC) O157:H7, especially in Osaka prefecture where about 6000 patients (mainly schoolchildren) suffered from diarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome (HUS) due to EHEC infection via school lunch. Our survey of doctors who ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268897007541

    authors: Yoh M,Honda T

    更新日期:1997-08-01 00:00:00

  • The role of symptomatic presentation in influenza A transmission risk.

    abstract::Computer models can be useful in planning interventions against novel strains of influenza. However such models sometimes make unsubstantiated assumptions about the relative infectivity of asymptomatic and symptomatic cases, or conversely assume there is no impact at all. Using household-level data from known-index st...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816002740

    authors: Wardell R,Prem K,Cowling BJ,Cook AR

    更新日期:2017-03-01 00:00:00