Abstract:
:The Northern Territory of Australia has had historically very high incidence rates of invasive Haemophilus influenzae type b disease in children less than 5 years of age, with the burden of disease greatest among Aboriginal infants less than 12 months. This study documents the impact of conjugate Hib vaccines introduced in 1993. Immunization rates were monitored using an existing immunization register, and case finding was done retrospectively using hospital and laboratory records. Following the vaccine introduction, the incidence fell abruptly to a seventh of its pre-vaccination level, in both Aboriginal and non-Aboriginal children. The effectiveness of PRP-OMPC (PedvaxHIB) was 97.5% and the overall effectiveness of the vaccination programme was 86.3%. The study shows Hib immunization as an effective intervention while discussing continuing needs for Hib control in high risk populations. It also illustrates the benefit of immunization registers in the evaluation of immunization programmes and assessment of vaccine effectiveness.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Markey P,Krause V,Boslego JW,Coplan PM,Dargan JM,Kaplan KMdoi
10.1017/s0950268801005155subject
Has Abstractpub_date
2001-02-01 00:00:00pages
31-6issue
1eissn
0950-2688issn
1469-4409journal_volume
126pub_type
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