The effectiveness of Haemophilus influenzae type b conjugate vaccines in a high risk population measured using immunization register data.

Abstract:

:The Northern Territory of Australia has had historically very high incidence rates of invasive Haemophilus influenzae type b disease in children less than 5 years of age, with the burden of disease greatest among Aboriginal infants less than 12 months. This study documents the impact of conjugate Hib vaccines introduced in 1993. Immunization rates were monitored using an existing immunization register, and case finding was done retrospectively using hospital and laboratory records. Following the vaccine introduction, the incidence fell abruptly to a seventh of its pre-vaccination level, in both Aboriginal and non-Aboriginal children. The effectiveness of PRP-OMPC (PedvaxHIB) was 97.5% and the overall effectiveness of the vaccination programme was 86.3%. The study shows Hib immunization as an effective intervention while discussing continuing needs for Hib control in high risk populations. It also illustrates the benefit of immunization registers in the evaluation of immunization programmes and assessment of vaccine effectiveness.

journal_name

Epidemiol Infect

authors

Markey P,Krause V,Boslego JW,Coplan PM,Dargan JM,Kaplan KM

doi

10.1017/s0950268801005155

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

31-6

issue

1

eissn

0950-2688

issn

1469-4409

journal_volume

126

pub_type

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