Patient and strain characteristics in relation to the outcome of meningococcal disease: a multivariate analysis.

Abstract:

:To investigate the joint association of patient and strain characteristics with the outcome of meningococcal disease (MD), data were collected on 563 consecutive cases of MD reported between 1989 and 1990 in The Netherlands. The meningococcal isolates were characterized with regard to their surface characteristics. Sequelae occurred in 8.5% of the patients, and were only associated with the presence of bacteraemia. The case-fatality rate was 7.7%. Infants aged < or = 5 months and patients in the age-groups of 10-19 years and > or = 50 years had an increased risk for a fatal outcome compared with children from 6 months to 9 years old (Odds Ratios [ORs]: 5.1, 3.4 and 9.8, respectively). The OR for females versus males was 2.3. The ORs for patients with bacteraemia, or a combination of bacteraemia and meningitis, compared with meningitic patients, were 2.3 and 3.1. Meningococcal strain characteristics did not influence the case-fatality rate substantially. In conclusion, host factors were found to be determinants for a fatal outcome of MD in The Netherlands from 1989 to 1990.

journal_name

Epidemiol Infect

authors

Scholten RJ,Bijlmer HA,Valkenburg HA,Dankert J

doi

10.1017/s0950268800057472

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

115-24

issue

1

eissn

0950-2688

issn

1469-4409

journal_volume

112

pub_type

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