A study of intranasally administered interferon A (rIFN-alpha 2A) for the seasonal prophylaxis of natural viral infections of the upper respiratory tract in healthy volunteers.

Abstract:

:The efficacy of interferon A (rIFN-alpha 2A), an Escherichia coli-derived interferon, in the prophylaxis of acute upper respiratory tract infection, was evaluated in a community-based double-blind placebo-controlled study in the Australian winter of 1985. The trial population of 412 healthy volunteers (190 males and 222 females, aged 18-65 years) self-administered 1.5, 3.0 and 6.0 megaunits (MU) of interferon A per day or a placebo, intranasally for 28 days. The period of study coincided with an outbreak of H3N2 influenza A (detected in 35 of the 107 acute specimens) as well as substantial numbers of respiratory syncytial virus and adenovirus infections. Rhinoviruses were isolated from only three specimens. In many cases, subjects had laboratory and clinical evidence of having had more than one respiratory tract infection during the period of the study. Viruses were detected in 54 or 107 acute specimens (49%). No statistically significant differences were noted between the various treatment groups in the incidence of laboratory-proven viral infection (virus isolation and/or antibody response). Analysis of reported symptoms indicated that blood-tinged mucus and nasal stuffiness occurred more frequently with higher doses of interferon. There appeared to be no clinical benefit from the use of interferon A in the amelioration of symptoms.

journal_name

Epidemiol Infect

authors

Tannock GA,Gillett SM,Gillett RS,Barry RD,Hensley MJ,Herd R,Reid AL,Saunders NA

doi

10.1017/s0950268800029484

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

611-21

issue

3

eissn

0950-2688

issn

1469-4409

journal_volume

101

pub_type

临床试验,杂志文章
  • Occupational blood and body fluid exposure in an Australian teaching hospital.

    abstract::To examine work-related blood and body fluid exposure (BBFE) among health-care workers (HCWs), to explore potential risk factors and to provide policy suggestions, a 6-year retrospective study of all reported BBFE among HCWs (1998-2003) was conducted in a 430-bed teaching hospital in Australia. Results showed that BBF...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268805005212

    authors: Bi P,Tully PJ,Pearce S,Hiller JE

    更新日期:2006-06-01 00:00:00

  • Risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus bacteraemia: a case-control study.

    abstract::A case-control study was undertaken in an acute district general hospital to identify risk factors for hospital-acquired bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA). Cases of hospital-acquired MRSA bacteraemia were defined as consecutive patients from whom MRSA was isolated from a blood sa...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0950268806006327

    authors: Carnicer-Pont D,Bailey KA,Mason BW,Walker AM,Evans MR,Salmon RL

    更新日期:2006-12-01 00:00:00

  • Risk factors for surgical site infections in abdominal surgeries in Ghana: emphasis on the impact of operating rooms door openings.

    abstract::Major surgery carried out in low- and middle-income countries is associated with a high risk of surgical site infections (SSI), but knowledge is limited regarding contributory factors to such infections. This study explores factors related to patients developing an SSI in a teaching hospital in Ghana. A prospective co...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268820001454

    authors: Bediako-Bowan AAA,Mølbak K,Kurtzhals JAL,Owusu E,Debrah S,Newman MJ

    更新日期:2020-07-01 00:00:00

  • The role of symptomatic presentation in influenza A transmission risk.

    abstract::Computer models can be useful in planning interventions against novel strains of influenza. However such models sometimes make unsubstantiated assumptions about the relative infectivity of asymptomatic and symptomatic cases, or conversely assume there is no impact at all. Using household-level data from known-index st...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816002740

    authors: Wardell R,Prem K,Cowling BJ,Cook AR

    更新日期:2017-03-01 00:00:00

  • Concomitant leptospirosis-hantavirus co-infection in acute patients hospitalized in Sri Lanka: implications for a potentially worldwide underestimated problem.

    abstract::Two global (re-)emerging zoonoses, leptospirosis and hantavirus infections, are clinically indistinguishable. Thirty-one patients, hospitalized in Sri Lanka for acute severe leptospirosis, were after exclusion of other potentially involved pathogens, prospectively screened with IgM ELISA for both pathogens. Of these, ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814003707

    authors: Sunil-Chandra NP,Clement J,Maes P,DE Silva HJ,VAN Esbroeck M,VAN Ranst M

    更新日期:2015-07-01 00:00:00

  • Molecular epidemiology of Bartonella species isolated from ground squirrels and other rodents in northern California.

    abstract::Bartonella spp. are endemic in wild rodents in many parts of the world. A study conducted in two northern California counties (Sonoma and Yolo) sampling California ground squirrels (Otospermophilus beecheyi) and four other rodent species (Peromyscus maniculatus, P. boylii, P. truei and Neotoma fuscipes) led to the iso...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816000108

    authors: Ziedins AC,Chomel BB,Kasten RW,Kjemtrup AM,Chang CC

    更新日期:2016-07-01 00:00:00

  • The impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia.

    abstract::Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) or high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number of viral, host, environmental and behavioural factors are suggested to be associated with the progressi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268818001668

    authors: Tasic D,Lazarevic I,Knezevic A,Tasic L,Pikula A,Perisic Z,Jovanovic T,Cupic M

    更新日期:2018-10-01 00:00:00

  • Usutu virus: A new threat?

    abstract::Usutu virus (USUV) is an emerging arbovirus that was first isolated in South Africa in 1959. This Flavivirus is maintained in the environment through a typical enzootic cycle involving mosquitoes and birds. USUV has spread to a large part of the European continent over the two decades mainly leading to substantial avi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,评审

    doi:10.1017/S0950268819001213

    authors: Clé M,Beck C,Salinas S,Lecollinet S,Gutierrez S,Van de Perre P,Baldet T,Foulongne V,Simonin Y

    更新日期:2019-01-01 00:00:00

  • Non-specific alert system for dengue epidemic outbreaks in areas of endemic malaria. A hospital-based evaluation in Cayenne (French Guiana).

    abstract::The emergence of dengue haemorrhagic fever is a public health problem in Latin America and the Caribbean. This study, carried out in French Guiana where malaria is endemic, evaluated the value and the limitations of a non-specific alert system including all patients admitted to the emergency department of Cayenne Hosp...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268802007641

    authors: Carme B,Sobesky M,Biard MH,Cotellon P,Aznar C,Fontanella JM

    更新日期:2003-02-01 00:00:00

  • Experimental studies on the infectivity of non-culturable forms of Campylobacter spp. in chicks and mice.

    abstract::The significance of non-culturable forms of Campylobacter spp., especially with regard to the epidemiology of this organism in poultry flocks, was explored. Two different experiments were conducted to produce non-culturable Campylobacter spp. and test their ability to colonize the animal gut. In the first experiment a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800059124

    authors: van de Giessen AW,Heuvelman CJ,Abee T,Hazeleger WC

    更新日期:1996-12-01 00:00:00

  • Serological diagnosis of leishmaniasis: on detecting infection as well as disease.

    abstract::Serological tests are very frequently used in epidemiological surveys of leishmaniasis and other parasitoses. Their sensitivity and specificity are generally defined with respect to parasitism and disease, rather than infection. The reason is that known positives are those individuals most likely to yield parasites, o...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800051074

    authors: Dye C,Vidor E,Dereure J

    更新日期:1993-06-01 00:00:00

  • Dynamics of Salmonella transmission on a British pig grower-finisher farm: a stochastic model.

    abstract::Previous modelling studies have estimated that between 1% and 10% of human salmonella infections are attributable to pig meat consumption. In response to this food safety threat the British pig industry have initiated a salmonella monitoring programme. It is anticipated that this programme will contribute to achieving...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268807008485

    authors: Hill AA,Snary EL,Arnold ME,Alban L,Cook AJ

    更新日期:2008-03-01 00:00:00

  • Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea.

    abstract::Hypermucoviscous (HV) isolates of Klebsiella pneumoniae have been linked to virulence potential in experimental infections. We examined 33 isolates of K. pneumoniae from patients with bacteraemia for the HV phenotype on agar culture, and determined their virulence potential by screening for capsular (K) serotype by po...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268812000933

    authors: Jung SW,Chae HJ,Park YJ,Yu JK,Kim SY,Lee HK,Lee JH,Kahng JM,Lee SO,Lee MK,Lim JH,Lee CH,Chang SJ,Ahn JY,Lee JW,Park YG

    更新日期:2013-02-01 00:00:00

  • Prevalence and growth kinetics of Shiga toxin-producing Escherichia coli (STEC) in bovine offal products in Japan.

    abstract::Recent epidemiological data suggest a link between the consumption of bovine offal products and Shiga toxin-producing Escherichia coli (STEC) infection in Japan. This study thus examined the prevalence of STEC in various types of these foods. PCR screened 229 bovine offal products for the presence of Shiga toxin (stx)...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811001105

    authors: Asakura H,Saito E,Momose Y,Ekawa T,Sawada M,Yamamoto A,Hasegawa A,Iwahori J,Tsutsui T,Osaka K,Matsushita T,Kakinuma M,Motoyama K,Hayama Y,Kitamoto H,Igimi S,Kasuga F

    更新日期:2012-04-01 00:00:00

  • Outer membrane characteristics of Salmonella enteritidis phage type 4 growing in chickens.

    abstract::Strains of Salmonella enteritidis belonging to phage type 4 (SE4) were grown in the peritoneal cavities of chickens, and without subculture on laboratory media examined for inducible in vivo phenotypic characteristics. These bacteria expressed three major outer membrane proteins (OMPs) of 33, 35 and 36 kilodaltons (kD...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800057174

    authors: Chart H,Conway D,Rowe B

    更新日期:1993-12-01 00:00:00

  • Streptococcal pharyngitis in general practice. 2. A note on dual infection and transient urinary abnormalities.

    abstract::In an incomplete study in 1965 microscopic haematuria in the second or third week after acute pharyngitis was found four times more often in patients with either microbiological or clinical evidence of dual infection with both group A streptococci and a virus than in patients with evidence only of infection with group...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800050159

    authors: Higgins PM

    更新日期:1992-10-01 00:00:00

  • A geostatistical investigation of agricultural and infrastructural risk factors associated with primary verotoxigenic E. coli (VTEC) infection in the Republic of Ireland, 2008-2013.

    abstract::Ireland reports the highest incidence of verotoxigenic Escherichia coli (VTEC) infection in Europe. This study investigated potential risk factors for confirmed sporadic and outbreak primary VTEC infections during 2008-2013. Overall, 989 VTEC infections including 521 serogroup O157 and 233 serogroup O26 were geo-refer...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026881600193X

    authors: Óhaiseadha C,Hynds PD,Fallon UB,O'Dwyer J

    更新日期:2017-01-01 00:00:00

  • The fall and rise of Group A Streptococcus diseases.

    abstract::Streptococcus pyogenes (or Group A Streptococcus, GAS) is a Gram-positive human pathogen responsible for a diverse array of superficial, invasive and immune-related diseases. GAS infections have historically been diseases of poverty and overcrowding, and remain a significant problem in the developing world and in disa...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268818002285

    authors: Barnett TC,Bowen AC,Carapetis JR

    更新日期:2018-08-15 00:00:00

  • Study of colonization resistance for Enterobacteriaceae in man by experimental contamination and biotyping as well as the possible role of antibodies in the clearance of these bacteria from the intestines.

    abstract::The colonization resistance (CR) of the digestive tract was determined in 10 healthy volunteers by oral contamination with a neomycin resistant Escherichia coli (NR-E. coli) strain and measurement of the faecal concentration of this strain during 14 days after the contamination. This 'gold standard' was compared with ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800049311

    authors: Apperloo-Renkema HZ,van der Waaij D

    更新日期:1991-12-01 00:00:00

  • Mixed viral infections causing acute gastroenteritis in children in a waterborne outbreak.

    abstract::We examined stool specimens for viral pathogens from 50 children referred to hospital due to acute gastroenteritis (AGE) resulting from consuming drinking water contaminated with sewage in a Finnish community using PCR methods. Rotavirus was detected in 33 (66%), human calicivirus in 31 (62%), and both in 40% of cases...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268809991671

    authors: Räsänen S,Lappalainen S,Kaikkonen S,Hämäläinen M,Salminen M,Vesikari T

    更新日期:2010-09-01 00:00:00

  • Adaptation of antibiotic treatment to clinical practice guidelines in patients aged ⩾65 years hospitalised due to community-acquired pneumonia.

    abstract::Early, conforming antibiotic treatment in elderly patients hospitalised for community-acquired pneumonia (CAP) is a key factor in the prognosis and mortality. The objective was to examine whether empirical antibiotic treatment was conforming according to the Spanish Society of Pulmonology and Thoracic Surgery guidelin...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S0950268818002121

    authors: Fernandez-Sierra MA,Rueda-Domingo MT,Rodriguez-Del-Aguila MM,Perez-Lozano MJ,Force L,Fernandez-Villa T,Astray J,Egurrola M,Castilla J,Sanz F,Toledo D,Dominguez A,Workgroup Project PI12\/02079.

    更新日期:2018-10-01 00:00:00

  • Cryptosporidium hominis genotypes involved in increased incidence and clusters of cases, Navarra, Spain, 2012.

    abstract::SUMMARY Two clusters of confirmed cryptosporidiosis infections were detected in Navarra, Spain, in the summer of 2012, in the context of an increased incidence in the region. Molecular subtyping of Cryptosporidium hominis determined that one cluster, occurring in an urban area, was due to the predominant circulating s...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814001836

    authors: Fuentes I,Martín C,Beristain X,Mazón A,Saugar JM,Blanco A,García Cenoz M,Valle-Cristia M,Ezpeleta C,Castilla J

    更新日期:2015-04-01 00:00:00

  • The prevalence of hepatitis B in Sweden; a statistical serosurvey of 3381 Swedish inhabitants.

    abstract::The prevalence of hepatitis B virus markers in the adult Swedish population was investigated according to age, sex, origin and demographic stratum. Sera were collected from 3382 persons in 1990-1. The sera were selected on a statistical basis considered to be representative of the Swedish population from adults aged >...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268897007838

    authors: Christenson B,Böttiger M,Grillner L

    更新日期:1997-10-01 00:00:00

  • Improved hepatitis C treatment response in younger patients: findings from the UK HCV National Register cohort study.

    abstract::In a cohort of 272 treatment-naive individuals with chronic hepatitis C infection acquired on a known date who were enrolled in the UK HCV National Register, a progressive improvement in response to treatment was found with the evolution of antiviral therapies from 20% (25/122) for interferon monotherapy to 63% (55/88...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811002317

    authors: Harris HE,Costella A,Amirthalingam G,Alexander G,Ramsay ME,Andrews N,UK HCV National Register Collaborators.,UK HCV National Register Steering Group.

    更新日期:2012-10-01 00:00:00

  • Impact of HIV on inpatient mortality and complications in stroke in Thailand: a National Database Study.

    abstract::The co-existence of stroke and HIV has increased in recent years, but the impact of HIV on post-stroke outcomes is poorly understood. We examined the impact of HIV on inpatient mortality, length of acute hospital stay and complications (pneumonia, respiratory failure, sepsis and convulsions), in hospitalized strokes i...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026881600340X

    authors: Cumming K,Tiamkao S,Kongbunkiat K,Clark AB,Bettencourt-Silva JH,Sawanyawisuth K,Kasemsap N,Mamas MA,Seeley JA,Myint PK

    更新日期:2017-04-01 00:00:00

  • An international outbreak of Vero cytotoxin-producing Escherichia coli O157 infection amongst tourists; a challenge for the European infectious disease surveillance network.

    abstract::In March 1997, an outbreak of Vero cytotoxin-producing Escherichia coli O157 (VTEC) infection occurred amongst holidaymakers returning from Fuerteventura, Canary Islands. For the investigation, a confirmed case was an individual staying in Fuerteventura during March 1997, with either E. coli O157 VTEC isolated in stoo...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268899002940

    authors: Pebody RG,Furtado C,Rojas A,McCarthy N,Nylen G,Ruutu P,Leino T,Chalmers R,de Jong B,Donnelly M,Fisher I,Gilham C,Graverson L,Cheasty T,Willshaw G,Navarro M,Salmon R,Leinikki P,Wall P,Bartlett C

    更新日期:1999-10-01 00:00:00

  • Protecting the vaccinating population in the face of a measles epidemic: assessing the impact of adjusted vaccination schedules.

    abstract::We investigated which vaccination schedule gives best protection to the vaccinating population, in case there is a measles epidemic in an area with low vaccine coverage. We considered combinations of an early measles vaccination (none, at 6 months or at 9 months), a measles-mumps-rubella (MMR) vaccination around the f...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268801006409

    authors: van den Hof S,Wallinga J,Widdowson MA,Conyn-van Spaendonck MA

    更新日期:2002-02-01 00:00:00

  • Species identification, antibiotic sensitivity and slime production of coagulase-negative staphylococci isolated from clinical specimens.

    abstract::Two hundred and seventy-five consecutive clinical isolates of coagulase-negative staphylococci, including strains associated with disease, contaminants and skin colonizers, were speciated, tested for slime production and for their sensitivity to a range of antibiotics. Staphylococcus epidermidis was the most commonly ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800029265

    authors: Deighton MA,Franklin JC,Spicer WJ,Balkau B

    更新日期:1988-08-01 00:00:00

  • Test characteristics of the tuberculin skin test and post-mortem examination for bovine tuberculosis diagnosis in cattle in Northern Ireland estimated by Bayesian latent class analysis with adjustments for covariates.

    abstract::The single intradermal comparative cervical tuberculin (SICCT) test and post-mortem examination are the main diagnostic tools for bovine tuberculosis (bTB) in cattle in the British Isles. Latent class modelling is often used to estimate the bTB test characteristics due to the absence of a gold standard. However, the r...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819000888

    authors: O'Hagan MJH,Ni H,Menzies FD,Pascual-Linaza AV,Georgaki A,Stegeman JA

    更新日期:2019-01-01 00:00:00

  • The emergence of wildlife species as a source of human rabies infection in Brazil.

    abstract::Forty-five human rabies virus isolates from a wide geographical area of Brazil were characterized using an anti-nucleoprotein monoclonal antibody panel and by partial nucleotide sequencing analysis of the nucleoprotein gene. Three major antigenic groups related to the antigenic variants maintained in domestic dogs, va...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268813000198

    authors: Favoretto SR,de Mattos CC,de Mattos CA,Campos AC,Sacramento DR,Durigon EL

    更新日期:2013-07-01 00:00:00