Abstract:
:Hypermucoviscous (HV) isolates of Klebsiella pneumoniae have been linked to virulence potential in experimental infections. We examined 33 isolates of K. pneumoniae from patients with bacteraemia for the HV phenotype on agar culture, and determined their virulence potential by screening for capsular (K) serotype by polymerase chain reaction and the presence of seven virulence factor genes. Fourteen (42·4%) isolates expressed the HV phenotype and 11 of these were serotype K1 or K2; these serotypes were not identified in HV-negative isolates. The genes rmpA, rmpA2, aerobactin, wabG and allS were significantly more frequent in HV than non-HV isolates. Multilocus sequence typing identified 21 sequence types (ST), eight of which were found in HV-positive isolates and the clonal relatedness of isolates of the most frequent types (ST23 and ST11) from different hospitals was confirmed by pulsed-field gel electrophoresis. The HV phenotype was more associated with community-acquired infection with a lower frequency of fatal underlying illness, but with significantly more focal infections, notably liver abscesses. Clinicians should be aware of such clinical impacts of the HV phenotype.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Jung SW,Chae HJ,Park YJ,Yu JK,Kim SY,Lee HK,Lee JH,Kahng JM,Lee SO,Lee MK,Lim JH,Lee CH,Chang SJ,Ahn JY,Lee JW,Park YGdoi
10.1017/S0950268812000933subject
Has Abstractpub_date
2013-02-01 00:00:00pages
334-40issue
2eissn
0950-2688issn
1469-4409pii
S0950268812000933journal_volume
141pub_type
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