Abstract:
:We investigated which vaccination schedule gives best protection to the vaccinating population, in case there is a measles epidemic in an area with low vaccine coverage. We considered combinations of an early measles vaccination (none, at 6 months or at 9 months), a measles-mumps-rubella (MMR) vaccination around the first birthday (at either 11 or 14 months), and MMR vaccination at an older age (at either 4 or 9 years). The different estimates on measures of protection (percentage of susceptibles, number of reported cases in an epidemic year, percentage of lifetime spent susceptible) relied on a mathematical model of decline of maternal antibody levels with age, and the impact of that antibody level on seroconversion and immunity. Model parameters were estimated from a Dutch population-based serological survey on measles antibodies. Different measures of protection favoured different vaccination schedules, but dropping the age of second MMR vaccination prevents considerably more cases than an extra early measles vaccination or dropping the age of first MMR vaccination.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
van den Hof S,Wallinga J,Widdowson MA,Conyn-van Spaendonck MAdoi
10.1017/s0950268801006409subject
Has Abstractpub_date
2002-02-01 00:00:00pages
47-57issue
1eissn
0950-2688issn
1469-4409journal_volume
128pub_type
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