Abstract:
:In 1996 Japan had a big outbreak of enterohaemorrhagic Escherichia coli (EHEC) O157:H7, especially in Osaka prefecture where about 6000 patients (mainly schoolchildren) suffered from diarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome (HUS) due to EHEC infection via school lunch. Our survey of doctors who took care of those patients showed that most patients had received antibiotics, especially fosfomycin which comprised 84% of the prescribed treatment. Since the administration of antibiotics for EHEC infection is under discussion, we analysed the effect of fosfomycin on production/release of verotoxins (VTs). Addition of fosfomycin into EHEC culture in CAYE broth at 2 and 5 h after start of incubation caused marked increase of VT1 release. This observation warns of the possibility of fosfomycin treatment making the disease worse.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Yoh M,Honda Tdoi
10.1017/s0950268897007541subject
Has Abstractpub_date
1997-08-01 00:00:00pages
101-3issue
1eissn
0950-2688issn
1469-4409journal_volume
119pub_type
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pub_type: 杂志文章,meta分析
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