Improved hepatitis C treatment response in younger patients: findings from the UK HCV National Register cohort study.

Abstract:

:In a cohort of 272 treatment-naive individuals with chronic hepatitis C infection acquired on a known date who were enrolled in the UK HCV National Register, a progressive improvement in response to treatment was found with the evolution of antiviral therapies from 20% (25/122) for interferon monotherapy to 63% (55/88) for pegylated interferon+ribavirin therapy. Multivariable analysis results showed increasing age to be associated with poorer response to therapy [odds ratio (OR) 0·84, 95% confidence interval (CI) 0·72-0·99, P=0·03] whereas time since infection was not associated with response (OR 0·93, 95% CI 0·44-1·98, P=0·85). Other factors significantly associated with a positive response were non-type 1 genotype (P<0·0001) and combination therapies (P<0·0001). During the first two decades of chronic HCV infection, treatment at a younger age was found to be more influential in achieving a sustained viral response than treating earlier in the course of infection.

journal_name

Epidemiol Infect

authors

Harris HE,Costella A,Amirthalingam G,Alexander G,Ramsay ME,Andrews N,UK HCV National Register Collaborators.,UK HCV National Register Steering Group.

doi

10.1017/S0950268811002317

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1830-7

issue

10

eissn

0950-2688

issn

1469-4409

pii

S0950268811002317

journal_volume

140

pub_type

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