An outbreak of hepatitis A in Gloucester, UK.

Abstract:

:During an outbreak of hepatitis A that occurred in Gloucester, UK between September 1989 and January 1991, 162 clinical cases were identified through notifications and laboratory reports, a monthly attack rate of 1.05 per 10,000 residents. The highest attack rate was seen in 5-14-year-olds. There were significant correlations between hepatitis A attack rates in the electoral wards of Gloucester and with the Jarman UPA 8 scores for the wards and with overcrowding, unemployment, under 5-year-olds and ethnic minority. The use of human normal immune globulin prophylaxis (HNIG) for household contacts was unsuccessful in ending the outbreak, partly because only one third of cases reported a household contact with recent hepatitis A. Our experience does not support the use of HNIG in stopping community-wide outbreaks of hepatitis A. Two public health campaigns were mounted during the outbreak; both were followed by a fall in the number of cases. Greater priority should be given to the implementation and evaluation of public health campaigns in future community-wide outbreaks of hepatitis A.

journal_name

Epidemiol Infect

authors

Majeed FA,Stuart JM,Cartwright KA,Room R,Gilkes JR,Smith MC,Watson BE

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

167-73

issue

1

eissn

0950-2688

issn

1469-4409

journal_volume

109

pub_type

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