Abstract：
:A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine using Enterococcus faecalis-infected dentin blocks. Sixty bovine dentin blocks were prepared and randomly divided into six groups of 10 each. E. faecalis was inoculated on 60 dentin blocks using the Luppens apparatus for 24 h and then the dentin blocks were soaked in 2% chlorhexidine or 1% alexidine solutions for 5 and 10 min, respectively. Sterile saline was used as a control. The antimicrobial efficacy was assessed by counting the number of bacteria adhering to the dentin surface and observing the degradation of bacterial shape or membrane rupture under a scanning electron microscope. Significantly fewer bacteria were observed in the 2% chlorhexidine- or 1% alexidine-soaked groups than in the control group (P<0.05). However, there was no significant difference in the number of bacteria adhering to the dentinal surface between the two experimental groups or between the two soaking time groups (P>0.05). Ruptured or antiseptic-attached bacteria were more frequently observed in the 10-min-soaked chlorhexidine and alexidine groups than in the 5-min-soaked chlorhexidine and alexidine groups. In conclusion, 10-min soaking with 1% alexidine or 2% chlorhexidine can be effective against E. faecalis infection.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Kim HS,Woo Chang S,Baek SH,Han SH,Lee Y,Zhu Q,Kum KYdoi
10.1038/ijos.2013.11subject
Has Abstractpub_date
2013-03-01 00:00:00pages
26-31issue
1eissn
1674-2818issn
2049-3169pii
ijos201311journal_volume
5pub_type
杂志文章abstract：:The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from the dental plaque of a healthy huma...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-0079-5
更新日期：2020-05-09 00:00:00
abstract：:Drug-induced gingival overgrowth (DIGO) is recognized as a side effect of nifedipine (NIF); however, the underlying molecular mechanisms remain unknown. In this study, we found that overexpressed miR-4651 inhibits cell proliferation and induces G0/G1-phase arrest in gingival mesenchymal stem cells (GMSCs) with or with...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-0076-8
更新日期：2020-03-31 00:00:00
abstract：:The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. These studies wer...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.59
更新日期：2013-09-01 00:00:00
abstract：:Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacrylo...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0019-9
更新日期：2018-06-21 00:00:00
abstract：:Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC develop...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11077
更新日期：2011-10-01 00:00:00
abstract：:In this study, we evaluate the influence of post surface pre-treatments on the bond strength of four different cements to glass fiber posts. Eighty extracted human maxillary central incisors and canines were endodontically treated and standardized post spaces were prepared. Four post pre-treatments were tested: (i) no...
journal_title：International journal of oral science
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijos.2013.83
更新日期：2014-03-01 00:00:00
abstract：:For a long time, oral disease is one of the major problems of the public health for its high prevalence and incidence throughout the world, which is especially true for low-income populations. Since China's economic reform in 1978, great changes have taken place in China. These changes have significant impact on and h...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11006
更新日期：2011-01-01 00:00:00
abstract：:Halitosis, bad breath or oral malodour are all synonyms for the same pathology. Halitosis has a large social and economic impact. For the majority of patients suffering from bad breath, it causes embarrassment and affects their social communication and life. Moreover,halitosis can be indicative of underlying diseases....
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2012.39
更新日期：2012-06-01 00:00:00
abstract：:Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that contro...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.41
更新日期：2013-06-01 00:00:00
abstract：:Sites of implantation with compromised biology may be unable to achieve the required level of angiogenic and osteogenic regeneration. The specific function and contribution of different cell types to the formation of prevascularized, osteogenic networks in co-culture remains unclear. To determine how bone marrow-deriv...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2016.39
更新日期：2016-12-16 00:00:00
abstract：:Retention wires permanently bonded to the anterior teeth are used after orthodontic treatment to prevent the teeth from relapsing to pre-treatment positions. A disadvantage of bonded retainers is biofilm accumulation on the wires, which produces a higher incidence of gingival recession, increased pocket depth and blee...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.69
更新日期：2015-03-23 00:00:00
abstract：:Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the per...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2017.1
更新日期：2017-03-01 00:00:00
abstract：:It is known that human papillomavirus (HPV) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours of the major and minor salivary glands of the head and neck. W...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.28
更新日期：2015-03-23 00:00:00
abstract：AIM:To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands. METHODOLOGY:Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X-radiation to one parotid gland using sin...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/ijos.08001
更新日期：2009-03-01 00:00:00
abstract：AIM:To examine what impact the loss of funding had on the utilization of the oral pathology service. METHODOLOGY:Biopsy records were retrieved and examined in the two year period before and after the elimination of the subsidies in 2003. RESULTS:After the loss of funding, there was a 31% decrease in the number of spe...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS.09032
更新日期：2009-09-01 00:00:00
abstract：:Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imper...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0027-9
更新日期：2018-09-03 00:00:00
abstract：:The presence of a large palatal or maxillary defect after partial or total maxillectomy for tumor, trauma or congenital deformation poses a challenge to prosthodontists, particularly when the use of an implant cannot be considered. This case report described the use of an air valve in a hollow silicone obturator to ma...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2012.22
更新日期：2012-06-01 00:00:00
abstract：:The human microbiome functions as an intricate and coordinated microbial network, residing throughout the mucosal surfaces of the skin, oral cavity, gastrointestinal tract, respiratory tract, and reproductive system. The oral microbiome encompasses a highly diverse microbiota, consisting of over 700 microorganisms, in...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-020-0082-x
更新日期：2020-04-30 00:00:00
abstract：:Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast (HGF), mouth epidermoid carcinoma cell (KB), lower gingival squamous c...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2012.14
更新日期：2012-06-01 00:00:00
abstract：:Tissue engineering allows the design of functionally active cells within supportive bio-scaffolds to promote the development of new tissues such as cartilage and bone for the restoration of pathologically altered tissues. However, all bone tissue engineering applications are limited by a shortage of stem cells. The ad...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS10045
更新日期：2010-09-01 00:00:00
abstract：:The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen (Col-I) from TiO2 nanotubes (NT-EPF surface). We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating platelet-mediated fibroblast recruitment and anchoring fibroblast-deri...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-00103-3
更新日期：2020-12-30 00:00:00
abstract：:Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute fo...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2016.38
更新日期：2016-09-29 00:00:00
abstract：:Dentin matrix metalloproteinases (MMPs) are a family of host-derived proteolytic enzymes trapped within mineralized dentin matrix, which have the ability to hydrolyze the organic matrix of demineralized dentin. After bonding with resins to dentin there are usually some exposed collagen fibrils at the bottom of the hyb...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS.09044
更新日期：2009-12-01 00:00:00
abstract：:Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly ov...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0062-1
更新日期：2019-10-01 00:00:00
abstract：:To modify two-step experimental etch-and-rinse dentin adhesive with different concentrations of riboflavin and to study its effect on the bond strength, degree of conversion, along with resin infiltration within the demineralized dentin substrate, an experimental adhesive-system was modified with different concentrati...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.49
更新日期：2015-06-26 00:00:00
abstract：:Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In host...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS11022
更新日期：2011-04-01 00:00:00
abstract：AIM:To investigate the effect of DAPT (gamma-secretase inhibitor) on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. METHODOLOGY:Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growt...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/ijos.08025
更新日期：2009-06-01 00:00:00
abstract：:Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out (KO) in mice. To the best of our knowledge, this is the first...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2015.57
更新日期：2016-06-30 00:00:00
abstract：:All-trans retinoic acid (ATRA) inhibits matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fibroblasts, skin fibroblasts, bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pul...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.63
更新日期：2014-09-01 00:00:00
abstract：:Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challenges for clinicians. Novel strategies utilising cell sheet technology to enhance...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0050-5
更新日期：2019-05-21 00:00:00
