Abstract:
:It is known that human papillomavirus (HPV) infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours of the major and minor salivary glands of the head and neck. We therefore assessed oral salivary gland neoplasms to identify associations between HPV and infection-related epidermal growth factor receptor (EGFR), cyclin-dependent kinase inhibitor 2A (CDKN2A/p16) and tumour protein p53 (TP53). Formalin-fixed, paraffin-embedded tissue samples from oral salivary gland carcinomas (n=51) and benign tumours (n=26) were analysed by polymerase chain reaction (PCR) analysis for several HPV species, including high-risk types 16 and 18. Evaluation of EGFR, CDKN2A, TP53 and cytomegalovirus (CMV) was performed by immunohistochemistry. Epstein-Barr virus (EBV) was evaluated by EBV-encoded RNA in situ hybridisation. We demonstrated that salivary gland tumours are not associated with HPV infection. The expression of EGFR, CDKN2A and TP53 may be associated with tumour pathology but is not induced by HPV. CMV and EBV were not detectable. In contrast to oral squamous cell carcinomas, HPV, CMV and EBV infections are not associated with malignant or benign neoplastic lesions of the salivary glands.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Senft E,Lemound J,Stucki-Koch A,Gellrich NC,Kreipe H,Hussein Kdoi
10.1038/ijos.2014.28subject
Has Abstractpub_date
2015-03-23 00:00:00pages
18-22issue
1eissn
1674-2818issn
2049-3169pii
ijos201428journal_volume
7pub_type
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:International journal of oral science
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更新日期:2011-01-01 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.4248/IJOS11077
更新日期:2011-10-01 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章
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journal_title:International journal of oral science
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更新日期:2016-06-30 00:00:00
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journal_title:International journal of oral science
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journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/ijos.2012.39
更新日期:2012-06-01 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijos.2012.70
更新日期:2012-12-01 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章
doi:10.1038/ijos.2013.14
更新日期:2013-03-01 00:00:00
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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journal_title:International journal of oral science
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更新日期:2019-10-02 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章,评审
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更新日期:2019-05-21 00:00:00
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journal_title:International journal of oral science
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更新日期:2018-09-03 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:International journal of oral science
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更新日期:2009-12-01 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章
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更新日期:2016-03-30 00:00:00
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journal_title:International journal of oral science
pub_type: 杂志文章,评审
doi:10.1038/s41368-020-0082-x
更新日期:2020-04-30 00:00:00