Abstract：
AIM:To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands. METHODOLOGY:Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X-radiation to one parotid gland using single-field or dual-field modality by linear accelerator. The dose-volume distributions between two IR groups were compared. Saliva from parotid glands and blood were collected at 0, 4, 8 and 16 weeks after irradiation. Parotid glands were removed at 16 weeks to evaluate tissue morphology. RESULTS:The irradiation dose volume distributions were significantly different between single and dual field irradiation groups (t=4.177, P=0.002), although dose volume histogramin (DVH) indicated the equal maximal dose in parotid glands. Saliva flow rates from IR side decreased dramatically at all time points in IR groups, especially in dual field irradiation group. The radiation caused changes of white blood cell count in blood, lactate dehydrogenase and amylase in serum, calcium, potassium and amylase in saliva. Morphologically, more severe radiation damage was found in irradiated parotid glands from dual field irradiation group than that from single field irradiation group. CONCLUSION:Data from this large animal model demonstrated that the radiation damage from the dual field irradiation was more severe than that of the single field irradiation at the same dose, suggesting that dose-volume distribution is an important factor in evaluation of the radiobiology of parotid glands.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Yan X,Hai B,Shan ZC,Zheng CY,Zhang CM,Wang SLdoi
10.4248/ijos.08001subject
Has Abstractpub_date
2009-03-01 00:00:00pages
16-25issue
1eissn
1674-2818issn
2049-3169journal_volume
1pub_type
杂志文章abstract：:The aim of the present real time in vivo micro-computed tomography (µCT) and histologic experiment was to assess the efficacy of guided bone regeneration (GBR) around standardized calvarial critical size defects (CSD) using bone marrow-derived mesenchymal stem cells (BMSCs), and collagen membrane (CM) with and without...
journal_title：International journal of oral science
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journal_title：International journal of oral science
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abstract：:The presence of a large palatal or maxillary defect after partial or total maxillectomy for tumor, trauma or congenital deformation poses a challenge to prosthodontists, particularly when the use of an implant cannot be considered. This case report described the use of an air valve in a hollow silicone obturator to ma...
journal_title：International journal of oral science
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journal_title：International journal of oral science
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journal_title：International journal of oral science
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journal_title：International journal of oral science
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journal_title：International journal of oral science
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journal_title：International journal of oral science
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journal_title：International journal of oral science
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journal_title：International journal of oral science
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更新日期：2010-09-01 00:00:00
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journal_title：International journal of oral science
pub_type： 杂志文章
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更新日期：2015-06-26 00:00:00
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journal_title：International journal of oral science
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journal_title：International journal of oral science
pub_type： 杂志文章,评审
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-12-01 00:00:00
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更新日期：2013-09-01 00:00:00
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journal_title：International journal of oral science
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更新日期：2017-12-01 00:00:00
abstract：:In this study, we evaluate the influence of post surface pre-treatments on the bond strength of four different cements to glass fiber posts. Eighty extracted human maxillary central incisors and canines were endodontically treated and standardized post spaces were prepared. Four post pre-treatments were tested: (i) no...
journal_title：International journal of oral science
pub_type： 杂志文章,随机对照试验
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更新日期：2014-03-01 00:00:00
