Abstract：
:Tissue engineering allows the design of functionally active cells within supportive bio-scaffolds to promote the development of new tissues such as cartilage and bone for the restoration of pathologically altered tissues. However, all bone tissue engineering applications are limited by a shortage of stem cells. The adult bone marrow stroma contains a subset of nonhematopoietic cells referred to as bone marrow mesenchymal stem cells (BMSCs). BMSCs are of interest because they are easily isolated from a small aspirate of bone marrow and readily generate single-cell-derived colonies. These cells have the capacity to undergo extensive replication in an undifferentiated state ex vivo. In addition, BMSCs have the potential to develop either in vitro or in vivo into distinct mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Thus, BMSCs are an attractive cell source for tissue engineering approaches. However, BMSCs are not homogeneous and the quantity of stem cells decreases in the bone marrow in aged population. A sequential loss of lineage differentiation potential has been found in the mixed culture of bone marrow stromal cells due to a heterogenous population. Therefore, a number of studies have proposed that homogenous bone marrow stem cells can be generated from clonal culture of bone marrow cells and that BMSC clones have the greatest potential for the application of bone regeneration in vivo.
journal_name
Int J Oral Scijournal_title
International journal of oral scienceauthors
Xiao Y,Mareddy S,Crawford Rdoi
10.4248/IJOS10045subject
Has Abstractpub_date
2010-09-01 00:00:00pages
127-35issue
3eissn
1674-2818issn
2049-3169journal_volume
2pub_type
杂志文章,评审abstract：:Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In host...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS11022
更新日期：2011-04-01 00:00:00
abstract：:This in vitro study aims to evaluate the crystal and surface microstructure of dental enamel after cold-light bleaching treatment. Twelve sound human premolars were cross-split into four specimens, namely, mesio-buccal (Group LP), disto-buccal (Group P), mesio-lingual (Group NP) and disto-lingual (Group L) specimens. ...
journal_title：International journal of oral science
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijos.2012.70
更新日期：2012-12-01 00:00:00
abstract：:For a long time, oral disease is one of the major problems of the public health for its high prevalence and incidence throughout the world, which is especially true for low-income populations. Since China's economic reform in 1978, great changes have taken place in China. These changes have significant impact on and h...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11006
更新日期：2011-01-01 00:00:00
abstract：:In this study, we evaluate the influence of post surface pre-treatments on the bond strength of four different cements to glass fiber posts. Eighty extracted human maxillary central incisors and canines were endodontically treated and standardized post spaces were prepared. Four post pre-treatments were tested: (i) no...
journal_title：International journal of oral science
pub_type： 杂志文章,随机对照试验
doi：10.1038/ijos.2013.83
更新日期：2014-03-01 00:00:00
abstract：:The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from the dental plaque of a healthy huma...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-0079-5
更新日期：2020-05-09 00:00:00
abstract：AIM:The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. METHODOLOGY:Ten subjects (6 women, 4 men; mean age 25.4 years) participated in the study. The mandibular movement, sagittal condylar inclination angle, and transversal condylar inclination angle of each subj...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS10071
更新日期：2010-12-01 00:00:00
abstract：AIM:To investigate the effect of DAPT (gamma-secretase inhibitor) on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. METHODOLOGY:Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growt...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/ijos.08025
更新日期：2009-06-01 00:00:00
abstract：:Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in ...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0048-z
更新日期：2019-05-09 00:00:00
abstract：:Sites of implantation with compromised biology may be unable to achieve the required level of angiogenic and osteogenic regeneration. The specific function and contribution of different cell types to the formation of prevascularized, osteogenic networks in co-culture remains unclear. To determine how bone marrow-deriv...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2016.39
更新日期：2016-12-16 00:00:00
abstract：:Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast (HGF), mouth epidermoid carcinoma cell (KB), lower gingival squamous c...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2012.14
更新日期：2012-06-01 00:00:00
abstract：:Secondary caries due to biofilm acids is a primary cause of dental composite restoration failure. To date, there have been no reports of dental composites that can repel protein adsorption and inhibit bacteria attachment. The objectives of this study were to develop a protein-repellent dental composite by incorporatin...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.77
更新日期：2015-06-26 00:00:00
abstract：:The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen (Col-I) from TiO2 nanotubes (NT-EPF surface). We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating platelet-mediated fibroblast recruitment and anchoring fibroblast-deri...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-00103-3
更新日期：2020-12-30 00:00:00
abstract：:The aim of the present real time in vivo micro-computed tomography (µCT) and histologic experiment was to assess the efficacy of guided bone regeneration (GBR) around standardized calvarial critical size defects (CSD) using bone marrow-derived mesenchymal stem cells (BMSCs), and collagen membrane (CM) with and without...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2015.34
更新日期：2016-03-30 00:00:00
abstract：:The human microbiome functions as an intricate and coordinated microbial network, residing throughout the mucosal surfaces of the skin, oral cavity, gastrointestinal tract, respiratory tract, and reproductive system. The oral microbiome encompasses a highly diverse microbiota, consisting of over 700 microorganisms, in...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-020-0082-x
更新日期：2020-04-30 00:00:00
abstract：:After teeth are replanted, there are two possible healing responses: periodontal ligament healing or ankylosis with subsequent replacement resorption. The purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing modes...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.51
更新日期：2015-06-26 00:00:00
abstract：:All-trans retinoic acid (ATRA) inhibits matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fibroblasts, skin fibroblasts, bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pul...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.63
更新日期：2014-09-01 00:00:00
abstract：AIM:To examine what impact the loss of funding had on the utilization of the oral pathology service. METHODOLOGY:Biopsy records were retrieved and examined in the two year period before and after the elimination of the subsidies in 2003. RESULTS:After the loss of funding, there was a 31% decrease in the number of spe...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS.09032
更新日期：2009-09-01 00:00:00
abstract：:Drug-induced gingival overgrowth (DIGO) is recognized as a side effect of nifedipine (NIF); however, the underlying molecular mechanisms remain unknown. In this study, we found that overexpressed miR-4651 inhibits cell proliferation and induces G0/G1-phase arrest in gingival mesenchymal stem cells (GMSCs) with or with...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-020-0076-8
更新日期：2020-03-31 00:00:00
abstract：AIM:To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands. METHODOLOGY:Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X-radiation to one parotid gland using sin...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/ijos.08001
更新日期：2009-03-01 00:00:00
abstract：:When adipose-derived stem cells (ASCs) are retrieved from the stromal vascular portion of adipose tissue, a large amount of mature adipocytes are often discarded. However, by modified ceiling culture technique based on their buoyancy, mature adipocytes can be easily isolated from the adipose cell suspension and dediff...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.4248/IJOS11044
更新日期：2011-07-01 00:00:00
abstract：:The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. These studies wer...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.59
更新日期：2013-09-01 00:00:00
abstract：:Bone remodelling keeps going through the lifespan of human by bone formation and bone resorption. In the craniofacial region, mandibles act as the main force for biting and chewing, and also become susceptible to a common bone-loss disease, namely, apical periodontitis, once infected dental pulp is not treated timely,...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-019-0058-x
更新日期：2019-08-26 00:00:00
abstract：:Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challenges for clinicians. Novel strategies utilising cell sheet technology to enhance...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0050-5
更新日期：2019-05-21 00:00:00
abstract：:Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imper...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/s41368-018-0027-9
更新日期：2018-09-03 00:00:00
abstract：:Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly ov...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/s41368-019-0062-1
更新日期：2019-10-01 00:00:00
abstract：:This study aimed to compare epithelial cells derived from human embryonic stem cells (hESCs) to human ameloblast-lineage cells (ALCs), as a way to determine their potential use as a cell source for ameloblast regeneration. Induced by various concentrations of bone morphogenetic protein 4 (BMP4), retinoic acid (RA) and...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.14
更新日期：2013-03-01 00:00:00
abstract：:A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine using Enterococcus faecalis-infected dentin blocks. Sixty bovine dentin blocks ...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2013.11
更新日期：2013-03-01 00:00:00
abstract：:Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC develop...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.4248/IJOS11077
更新日期：2011-10-01 00:00:00
abstract：:To modify two-step experimental etch-and-rinse dentin adhesive with different concentrations of riboflavin and to study its effect on the bond strength, degree of conversion, along with resin infiltration within the demineralized dentin substrate, an experimental adhesive-system was modified with different concentrati...
journal_title：International journal of oral science
pub_type： 杂志文章
doi：10.1038/ijos.2014.49
更新日期：2015-06-26 00:00:00
abstract：:The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last few decades, but root development remains not well understood. Here we review the root development proc...
journal_title：International journal of oral science
pub_type： 杂志文章,评审
doi：10.1038/ijos.2012.61
更新日期：2012-12-01 00:00:00
